Π”ΠΈΠΏΠ»ΠΎΠΌ, курсовая, ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½Π°Ρ Ρ€Π°Π±ΠΎΡ‚Π°
ΠŸΠΎΠΌΠΎΡ‰ΡŒ Π² написании студСнчСских Ρ€Π°Π±ΠΎΡ‚

БСлСкция Π›ΠΠš ΠΊΠ»Π΅Ρ‚ΠΊΠ°ΠΌΠΈ Π±Π΅Π»ΠΊΠ° Tag7 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΊΠ»ΠΎΠ½ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰Π΅Π³ΠΎ Π³Π΅Π½Π°

Π”ΠΈΡΡΠ΅Ρ€Ρ‚Π°Ρ†ΠΈΡΠŸΠΎΠΌΠΎΡ‰ΡŒ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈΠ£Π·Π½Π°Ρ‚ΡŒ ΡΡ‚ΠΎΠΈΠΌΠΎΡΡ‚ΡŒΠΌΠΎΠ΅ΠΉ Ρ€Π°Π±ΠΎΡ‚Ρ‹

Автор Π²Ρ‹Ρ€Π°ΠΆΠ°Π΅Ρ‚ Π³Π»ΡƒΠ±ΠΎΠΊΡƒΡŽ ΠΏΡ€ΠΈΠ·Π½Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ Π‘. Π›. ΠšΠΈΡΠ΅Π»Π΅Π²Ρƒ ΠΈ Н. Π’. Π“Π½ΡƒΡ‡Π΅Π²Ρƒ Π·Π° ΠΏΠΎΡΡ‚оянноС Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΊ Ρ€Π°Π±ΠΎΡ‚Π΅ ΠΈ Π½Π°ΡƒΡ‡Π½ΠΎΠ΅ руководство. Автор Ρ‚Π°ΠΊΠΆΠ΅ Π±Π»Π°Π³ΠΎΠ΄Π°Ρ€ΠΈΡ‚ Π›. П. Π‘Π°Ρ‰Π΅Π½ΠΊΠΎ ΠΈ Π²ΡΠ΅Ρ… сотрудников Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€ΠΈΠΈ молСкулярной ΠΈΠΌΠΌΡƒΠ½ΠΎΠ³Π΅Π½Π΅Ρ‚ΠΈΠΊΠΈ Ρ€Π°ΠΊΠ° ΠΈ Π³Ρ€ΡƒΠΏΠΏΡ‹ Π³Π΅Π½ΠΎΡ‚Π΅Ρ€Π°ΠΏΠΈΠΈ Ρ€Π°ΠΊΠ° Π·Π° ΠΏΠΎΠΌΠΎΡ‰ΡŒ Π² Ρ€Π°Π±ΠΎΡ‚Π΅ ΠΈ Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ диссСртации. Автор Π±Π»Π°Π³ΠΎΠ΄Π°Ρ€Π΅Π½ АлСксСю Π’. ΠšΠΈΠ±Π°Ρ€Π΄ΠΈΠ½Ρƒ ΠΈ Π’Π°ΠΌΠ°Ρ€Π΅ И. Π›ΡƒΠΊΡŒΡΠ½ΠΎΠ²ΠΎΠΉ Π·Π° ΠΏΠΎΠΌΠΎΡ‰ΡŒ ΠΈ ΠΏΠΎΠ΄Π΄Π΅Ρ€ΠΆΠΊΡƒ Π² ΠΏΡ€ΠΎΡ†Π΅ΡΡΠ΅ Ρ€Π°Π±ΠΎΡ‚Ρ‹… Π§ΠΈΡ‚Π°Ρ‚ΡŒ Π΅Ρ‰Ρ‘ >

Π‘ΠΎΠ΄Π΅Ρ€ΠΆΠ°Π½ΠΈΠ΅

  • БПИБОК Π‘ΠžΠšΠ ΠΠ©Π•ΠΠ˜Π™
  • Π’Π’Π•Π”Π•ΠΠ˜Π•
  • ΠžΠ‘Π—ΠžΠ  Π›Π˜Π’Π•Π ΠΠ’Π£Π Π«
  • 1. Основной ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏ Π²Ρ€ΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈ ΠΏΡ€ΠΈΠΎΠ±Ρ€Π΅Ρ‚Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡƒΠ½Π½ΠΎΠ³ΠΎ ΠΎΡ‚Π²Π΅Ρ‚Π°
  • 2. Π Π΅Ρ†Π΅ΠΏΡ‚ΠΎΡ€Ρ‹, Π²ΠΎΠ²Π»Π΅Ρ‡Π΅Π½Π½Ρ‹Π΅ Π² Π½Π΅ΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹ΠΉ ΠΈΠΌΠΌΡƒΠ½Π½Ρ‹ΠΉ ΠΎΡ‚Π²Π΅Ρ‚
    • 2. 1. ΠžΠ±Ρ‰Π°Ρ характСристика
    • 2. 2. БСмСйство Toll/IL-IR
  • 3. Π‘Π΅Π»ΠΊΠΎΠ²Ρ‹Π΅ Ρ„Π°ΠΊΡ‚ΠΎΡ€Ρ‹, ΠΏΡ€ΠΎΠ΄ΡƒΡ†ΠΈΡ€ΡƒΠ΅ΠΌΡ‹Π΅ Π² ΠΏΡ€ΠΎΡ†Π΅ΡΡΠ΅ ΠΈΠΌΠΌΡƒΠ½Π½ΠΎΠ³ΠΎ ΠΎΡ‚Π²Π΅Ρ‚Π°: сигналы опасности
    • 3. 1. ΠŸΡ€ΡΠΌΠΎΠ΅ цитолитичСскоС дСйствиС Π½Π° Ρ‡ΡƒΠΆΠ΅Ρ€ΠΎΠ΄Π½Ρ‹ΠΉ Π°Π½Ρ‚ΠΈΠ³Π΅Π½
    • 3. 2. Π₯Смоаттракция (хСмотаксис)
    • 3. 3. Бтимуляция ΠΊΠ»Π΅ΠΏΠ°Π»ΡŒΠ½Ρ‹Ρ… Π’- ΠΈ Π’- Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² ΠΈ ΠΊΠ»Π΅Ρ‚ΠΎΠΊ Π²Ρ€ΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚Π°
  • 4. Роль сигналов опасности Π² ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²ΠΎΠΌ ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚Π΅
    • 4. 1. Π›ΠΠš ΠΊΠ»Π΅Ρ‚ΠΊΠΈ ΠΊΠ°ΠΊ in vitro модСль для изучСния ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚Π°
    • 4. 2. ΠŸΡ€ΠΈΡ‡ΠΈΠ½Ρ‹ иммунологичСской толСрантности ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ° Π² ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΈ ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
    • 4. 3. ΠœΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΡ иммуногСнности с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ сигналов опасности
  • 5. Π˜Π½Π΄ΡƒΠΊΡ†ΠΈΡ ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π³ΠΈΠ±Π΅Π»ΠΈ ΠΊΠ»Π΅Ρ‚ΠΎΠΊ-мишСнСй, ΠΏΠΎΡ€Π°ΠΆΠ΅Π½Π½Ρ‹Ρ… Ρ‡ΡƒΠΆΠ΅Ρ€ΠΎΠ΄Π½Ρ‹ΠΌ Π°Π½Ρ‚ΠΈΠ³Π΅Π½ΠΎΠΌ: 5. 1 ΠšΠ»Π°ΡΡΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΡ ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠΉ Π³ΠΈΠ±Π΅Π»ΠΈ: Π½Π΅ΠΊΡ€ΠΎΠ· ΠΈ Π°ΠΏΠΎΠΏΡ‚ΠΎΠ·
    • 5. 2. ΠžΡΠ½ΠΎΠ²Π½Ρ‹Π΅ ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΈ Π°ΠΏΠΎΠΏΡ‚ΠΎΠ·Π°
    • 5. 3. ΠžΡΠ½ΠΎΠ²Π½Ρ‹Π΅ ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΡ‹ трансдукции апоптотичСского сигнала
      • 5. 3. 1. Роль Π°Π΄Π°ΠΏΡ‚ΠΎΡ€Π½Ρ‹Ρ… ΠΌΠΎΠ»Π΅ΠΊΡƒΠ» Π² Π°ΠΏΠΎΠΏΡ‚ΠΎΠ·Π΅
      • 5. 3. 2. Π­Ρ„Ρ„Π΅ΠΊΡ‚ΠΎΡ€Π½Ρ‹Π΅ ΠΌΠΎΠ»Π΅ΠΊΡƒΠ»Ρ‹: идСнтификация, ΠΏΡƒΡ‚ΠΈ Π°ΠΊΡ‚ΠΈΠ²Π°Ρ†ΠΈΠΈ ΠΈ ΠΎΡΡƒΡ‰Π΅ΡΡ‚влСния эффСкторных Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΉ Π² ΠΏΡ€ΠΎΡ†Π΅ΡΡΠ΅ Π°ΠΏΠΎΠΏΡ‚ΠΎΠ·Π°
    • 5. 4. РСгуляция «Π°ΠΏΠΎΠΏΡ‚отичСской ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΡ‹»: ΠΈΠ½Π³ΠΈΠ±ΠΈΡ‚ΠΎΡ€Ρ‹ ΠΈ Π°ΠΊΡ‚ΠΈΠ²Π°Ρ‚ΠΎΡ€Ρ‹ Π°ΠΏΠΎΠΏΡ‚ΠΎΠ·Π° ΠΈ ΠΈΡ… Π·Π½Π°Ρ‡Π΅Π½ΠΈΠ΅ для ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ°

БСлСкция Π›ΠΠš ΠΊΠ»Π΅Ρ‚ΠΊΠ°ΠΌΠΈ Π±Π΅Π»ΠΊΠ° Tag7 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΊΠ»ΠΎΠ½ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰Π΅Π³ΠΎ Π³Π΅Π½Π° (Ρ€Π΅Ρ„Π΅Ρ€Π°Ρ‚, курсовая, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½Π°Ρ)

Одной ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Ρ… ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌ соврСмСнности являСтся рост Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, связанных с Π΄ΠΈΡΡ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΈΠΌΠΌΡƒΠ½Π½ΠΎΠΉ систСмы ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ°. Π’ ΡΠ²ΡΠ·ΠΈ с ΡΡ‚ΠΈΠΌ ΠΏΡ€ΠΈΠΎΡ€ΠΈΡ‚Π΅Ρ‚Π½ΠΎΠΉ Π·Π°Π΄Π°Ρ‡Π΅ΠΉ молСкулярной Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρ‹ являСтся ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ молСкулярных ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚Π°.

Π˜Π·Π²Π΅ΡΡ‚Π½Ρ‹ Π΄Π²Π° Π²ΠΈΠ΄Π° ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚Π°, ΡΡ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π²ΡˆΠΈΠ΅ΡΡ Π² ΠΏΡ€ΠΎΡ†Π΅ΡΡΠ΅ ΡΠ²ΠΎΠ»ΡŽΡ†ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ развития: Π²Ρ€ΠΎΠΆΠ΄Π΅Π½Π½Ρ‹ΠΉ ΠΈ ΠΏΡ€ΠΈΠΎΠ±Ρ€Π΅Ρ‚Π΅Π½Π½Ρ‹ΠΉ. Π’Ρ€ΠΎΠΆΠ΄Π΅Π½Π½Ρ‹ΠΉ ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚ Π² Ρ‚ΠΎΠΉ ΠΈΠ»ΠΈ ΠΈΠ½ΠΎΠΉ Ρ„ΠΎΡ€ΠΌΠ΅ присутствуСт Π²ΠΎ Π²ΡΠ΅Ρ… ΠΌΠ½ΠΎΠ³ΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ°Ρ… ΠΈ ΡΠ²Π»ΡΠ΅Ρ‚ся филогСнСтичСски Π±ΠΎΠ»Π΅Π΅ Π΄Ρ€Π΅Π²Π½Π΅ΠΉ систСмой, Ρ‚ΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ ΠΏΡ€ΠΈΠΎΠ±Ρ€Π΅Ρ‚Π΅Π½Π½Ρ‹ΠΉ ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚, слоТившийся Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ ΠΏΠΎΠ·Π΄Π½Π΅Π΅, Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π΅Π½ прСимущСствСнно для ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡ‚Π°ΡŽΡ‰ΠΈΡ….

ΠŸΡ€ΠΈΠΎΡ€ΠΈΡ‚Π΅Ρ‚ Π² ΠΈΠ΅Ρ€Π°Ρ€Ρ…ΠΈΠΈ ΠΈΠΌΠΌΡƒΠ½Π½Ρ‹Ρ… Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΉ Ρ‚Ρ€Π°Π΄ΠΈΡ†ΠΈΠΎΠ½Π½ΠΎ отдавался ΠΏΡ€ΠΈΠΎΠ±Ρ€Π΅Ρ‚Π΅Π½Π½ΠΎΠΌΡƒ ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚Ρƒ. Однако Π² Π½Π°ΡΡ‚оящСС врСмя установлСно, Ρ‡Ρ‚ΠΎ Π²Ρ€ΠΎΠΆΠ΄Π΅Π½Π½Ρ‹ΠΉ ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ Π²Π°ΠΆΠ΅Π½ для осущСствлСния ΠΈΠΌΠΌΡƒΠ½Π½ΠΎΠ³ΠΎ ΠΎΡ‚Π²Π΅Ρ‚Π°. Π‘ΠΎΠ»Π΅Π΅ Ρ‚ΠΎΠ³ΠΎ, Ρ‚ΠΎΠ»ΡŒΠΊΠΎ координированная Ρ€Π°Π±ΠΎΡ‚Π° ΠΎΠ±Π΅ΠΈΡ… Ρ„ΠΎΡ€ΠΌ ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚Π° обСспСчиваСт Π½Π°Π΄Π΅ΠΆΠ½ΡƒΡŽ Π·Π°Ρ‰ΠΈΡ‚Ρƒ ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ° ΠΎΡ‚ Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠ°Π»ΡŒΠ½ΠΎΠΉ, Π³Ρ€ΠΈΠ±ΠΊΠΎΠ²ΠΎΠΉ, вирусной ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΉ ΠΈ Π·Π»ΠΎΠΊΠ°Ρ‡Π΅ΡΡ‚Π²Π΅Π½Π½Ρ‹Ρ… Π½ΠΎΠ²ΠΎΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠΉ.

Π˜Π·ΡƒΡ‡Π΅Π½ΠΈΠ΅ ΠΈ ΠΊΠ»ΠΎΠ½ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ Π³Π΅Π½ΠΎΠ², Π²ΠΎΠ²Π»Π΅Ρ‡Π΅Π½Π½Ρ‹Ρ… Π² Ρ€Π°Π±ΠΎΡ‚Ρƒ Π²Ρ€ΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈ ΠΏΡ€ΠΈΠΎΠ±Ρ€Π΅Ρ‚Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚Π° позволяСт Π³Π»ΡƒΠ±ΠΆΠ΅ ΠΏΠΎΠ½ΡΡ‚ΡŒ ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌ Ρ€Π°Π±ΠΎΡ‚Ρ‹ ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚Π° Π² Π½ΠΎΡ€ΠΌΠ΅ ΠΈ ΠΏΡ€ΠΈΡ‡ΠΈΠ½Ρ‹ сбоСв Π² ΡΡ‚ΠΎΠΌ ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΠ΅, Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π½Ρ‹Π΅ для Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠΉ.

ΠžΠ‘Π—ΠžΠ  Π›Π˜Π’Π•Π ΠΠ’Π£Π Π«.

Π²Ρ‹Π²ΠΎΠ΄Ρ‹.

1 Π’ΠΏΠ΅Ρ€Π²Ρ‹Π΅ ΠΊΠ»ΠΎΠ½ΠΈΡ€ΠΎΠ²Π°Π½Π° ΠΊΠ”ΠΠš ΠΈ Π³Π΅Π½ΠΎΠΌΠ½Π°Ρ копия Π³Π΅Π½Π° tag7 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°. Π‘ΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰Π°Ρ аминокислотная ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ Π³Π΅Π½Π° tag7 проявляСт гомологию с Π³Π΅Π½ΠΎΠΌ tag 7ΠΌΡ‹ΡˆΠΈ ΠΈ PGRP насСкомых T. ni, Π° ΡΡ‚руктурная организация Π³Π΅Π½Π° tag7 консСрвативна для ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡ‚Π°ΡŽΡ‰ΠΈΡ….

2 Показан сСкрСторный Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ Π±Π΅Π»ΠΊΠ° Tag7 ΠΈ Π΅Π³ΠΎ прСимущСствСнная локализация Π² Π»ΠΈΠΌΡ„ΠΎΠΈΠ΄Π½Ρ‹Ρ… ΠΊΠ»Π΅Ρ‚ΠΊΠ°Ρ…. НС ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½Π° экспрСссия tag7 Π² ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²Ρ‹Ρ… ΠΊΠ»Π΅Ρ‚ΠΊΠ°Ρ….

3 ΠžΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½Π° экспрСссия мРНК tag7 Π² Π½Π΅Π°ΠΊΡ‚ΠΈΠ²ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… Π»Π΅ΠΉΠΊΠΎΡ†ΠΈΡ‚Π°Ρ… пСрифСричСской ΠΊΡ€ΠΎΠ²ΠΈ Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… Π΄ΠΎΠ½ΠΎΡ€ΠΎΠ² ΠΈ Π›ΠΠš ΠΊΠ»Π΅Ρ‚ΠΊΠ°Ρ… Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΡƒΡΡ‚Π°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, Ρ‡Ρ‚ΠΎ ΠΊΡƒΠ»ΡŒΡ‚ΠΈΠ²ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ Π»Π΅ΠΉΠΊΠΎΡ†ΠΈΡ‚ΠΎΠ² Π² ΠΏΡ€ΠΈΡΡƒΡ‚ствии высоких Π΄ΠΎΠ· ΠΈΠ½Ρ‚Π΅Ρ€Π»Π΅ΠΉΠΊΠΈΠ½Π° 2 ΠΈΠ½Π΄ΡƒΡ†ΠΈΡ€ΡƒΠ΅Ρ‚ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ профиля экспрСссии tag7.

4 ΠžΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½ΠΎ присутствиС Π±Π΅Π»ΠΊΠ° Tag7 Π² ΡΡƒΠΏΠ΅Ρ€Π½Π°Ρ‚Π°Π½Ρ‚Π΅ Π›ΠΠš ΠΊΠ»Π΅Ρ‚ΠΎΠΊ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… Π½Π° 4 ΠΈ 6 дСнь ΠΈΠ½ΠΊΡƒΠ±Π°Ρ†ΠΈΠΈ Π»Π΅ΠΉΠΊΠΎΡ†ΠΈΡ‚ΠΎΠ² пСрифСричСской ΠΊΡ€ΠΎΠ²ΠΈ с ΠΈΠ½Ρ‚Π΅Ρ€Π»Π΅ΠΉΠΊΠΈΠ½ΠΎΠΌ-2. Π”Π°Π½Π½Ρ‹ΠΉ Π±Π΅Π»ΠΎΠΊ проявляСт Ρ†ΠΈΡ‚ΠΎΠ»ΠΈΡ‚ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ Π² ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ трансформированных ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… Π»ΠΈΠ½ΠΈΠΉ L929 ΠΈ Jurkat, индуцируя ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΡƒΡŽ гибСль ΠΏΠΎ ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΡƒ Π°ΠΏΠΎΠΏΡ‚ΠΎΠ·Π°.

Автор Π²Ρ‹Ρ€Π°ΠΆΠ°Π΅Ρ‚ Π³Π»ΡƒΠ±ΠΎΠΊΡƒΡŽ ΠΏΡ€ΠΈΠ·Π½Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ Π‘. Π›. ΠšΠΈΡΠ΅Π»Π΅Π²Ρƒ ΠΈ Н. Π’. Π“Π½ΡƒΡ‡Π΅Π²Ρƒ Π·Π° ΠΏΠΎΡΡ‚оянноС Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΊ Ρ€Π°Π±ΠΎΡ‚Π΅ ΠΈ Π½Π°ΡƒΡ‡Π½ΠΎΠ΅ руководство. Автор Ρ‚Π°ΠΊΠΆΠ΅ Π±Π»Π°Π³ΠΎΠ΄Π°Ρ€ΠΈΡ‚ Π›. П. Π‘Π°Ρ‰Π΅Π½ΠΊΠΎ ΠΈ Π²ΡΠ΅Ρ… сотрудников Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€ΠΈΠΈ молСкулярной ΠΈΠΌΠΌΡƒΠ½ΠΎΠ³Π΅Π½Π΅Ρ‚ΠΈΠΊΠΈ Ρ€Π°ΠΊΠ° ΠΈ Π³Ρ€ΡƒΠΏΠΏΡ‹ Π³Π΅Π½ΠΎΡ‚Π΅Ρ€Π°ΠΏΠΈΠΈ Ρ€Π°ΠΊΠ° Π·Π° ΠΏΠΎΠΌΠΎΡ‰ΡŒ Π² Ρ€Π°Π±ΠΎΡ‚Π΅ ΠΈ Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ диссСртации. Автор Π±Π»Π°Π³ΠΎΠ΄Π°Ρ€Π΅Π½ АлСксСю Π’. ΠšΠΈΠ±Π°Ρ€Π΄ΠΈΠ½Ρƒ ΠΈ Π’Π°ΠΌΠ°Ρ€Π΅ И. Π›ΡƒΠΊΡŒΡΠ½ΠΎΠ²ΠΎΠΉ Π·Π° ΠΏΠΎΠΌΠΎΡ‰ΡŒ ΠΈ ΠΏΠΎΠ΄Π΄Π΅Ρ€ΠΆΠΊΡƒ Π² ΠΏΡ€ΠΎΡ†Π΅ΡΡΠ΅ Ρ€Π°Π±ΠΎΡ‚Ρ‹.

ΠŸΠΎΠΊΠ°Π·Π°Ρ‚ΡŒ вСсь тСкст

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