Π‘Π΅Π»Π΅ΠΊΡΠΈΡ ΠΠΠ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ Π±Π΅Π»ΠΊΠ° Tag7 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΊΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ΅Π³ΠΎ Π³Π΅Π½Π°
ΠΠ²ΡΠΎΡ Π²ΡΡΠ°ΠΆΠ°Π΅Ρ Π³Π»ΡΠ±ΠΎΠΊΡΡ ΠΏΡΠΈΠ·Π½Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Π‘. Π. ΠΠΈΡΠ΅Π»Π΅Π²Ρ ΠΈ Π. Π. ΠΠ½ΡΡΠ΅Π²Ρ Π·Π° ΠΏΠΎΡΡΠΎΡΠ½Π½ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΊ ΡΠ°Π±ΠΎΡΠ΅ ΠΈ Π½Π°ΡΡΠ½ΠΎΠ΅ ΡΡΠΊΠΎΠ²ΠΎΠ΄ΡΡΠ²ΠΎ. ΠΠ²ΡΠΎΡ ΡΠ°ΠΊΠΆΠ΅ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠΈΡ Π. Π. Π‘Π°ΡΠ΅Π½ΠΊΠΎ ΠΈ Π²ΡΠ΅Ρ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠΎΠ² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π΅ΡΠΈΠΊΠΈ ΡΠ°ΠΊΠ° ΠΈ Π³ΡΡΠΏΠΏΡ Π³Π΅Π½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ°ΠΊΠ° Π·Π° ΠΏΠΎΠΌΠΎΡΡ Π² ΡΠ°Π±ΠΎΡΠ΅ ΠΈ Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ. ΠΠ²ΡΠΎΡ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ΅Π½ ΠΠ»Π΅ΠΊΡΠ΅Ρ Π. ΠΠΈΠ±Π°ΡΠ΄ΠΈΠ½Ρ ΠΈ Π’Π°ΠΌΠ°ΡΠ΅ Π. ΠΡΠΊΡΡΠ½ΠΎΠ²ΠΎΠΉ Π·Π° ΠΏΠΎΠΌΠΎΡΡ ΠΈ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠ°Π±ΠΎΡΡ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΠΠ‘ΠΠ Π‘ΠΠΠ ΠΠ©ΠΠΠΠ
- ΠΠΠΠΠΠΠΠ
- ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- 1. ΠΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΠΏΡΠΈΠ½ΡΠΈΠΏ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ°
- 2. Π Π΅ΡΠ΅ΠΏΡΠΎΡΡ, Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½Π½ΡΠ΅ Π² Π½Π΅ΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΠΉ ΠΈΠΌΠΌΡΠ½Π½ΡΠΉ ΠΎΡΠ²Π΅Ρ
- 2. 1. ΠΠ±ΡΠ°Ρ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°
- 2. 2. Π‘Π΅ΠΌΠ΅ΠΉΡΡΠ²ΠΎ Toll/IL-IR
- 3. ΠΠ΅Π»ΠΊΠΎΠ²ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ, ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΠ΅ΠΌΡΠ΅ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ°: ΡΠΈΠ³Π½Π°Π»Ρ ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ
- 3. 1. ΠΡΡΠΌΠΎΠ΅ ΡΠΈΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π½Π° ΡΡΠΆΠ΅ΡΠΎΠ΄Π½ΡΠΉ Π°Π½ΡΠΈΠ³Π΅Π½
- 3. 2. Π₯Π΅ΠΌΠΎΠ°ΡΡΡΠ°ΠΊΡΠΈΡ (Ρ Π΅ΠΌΠΎΡΠ°ΠΊΡΠΈΡ)
- 3. 3. Π‘ΡΠΈΠΌΡΠ»ΡΡΠΈΡ ΠΊΠ»Π΅ΠΏΠ°Π»ΡΠ½ΡΡ Π’- ΠΈ Π- Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°
- 4. Π ΠΎΠ»Ρ ΡΠΈΠ³Π½Π°Π»ΠΎΠ² ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ Π² ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΌ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ΅
- 4. 1. ΠΠΠ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΊΠ°ΠΊ in vitro ΠΌΠΎΠ΄Π΅Π»Ρ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°
- 4. 2. ΠΡΠΈΡΠΈΠ½Ρ ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΠ»Π΅ΡΠ°Π½ΡΠ½ΠΎΡΡΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ
- 4. 3. ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΠΎΡΡΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΈΠ³Π½Π°Π»ΠΎΠ² ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ
- 5. ΠΠ½Π΄ΡΠΊΡΠΈΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π³ΠΈΠ±Π΅Π»ΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ-ΠΌΠΈΡΠ΅Π½Π΅ΠΉ, ΠΏΠΎΡΠ°ΠΆΠ΅Π½Π½ΡΡ
ΡΡΠΆΠ΅ΡΠΎΠ΄Π½ΡΠΌ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠΌ: 5. 1 ΠΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π³ΠΈΠ±Π΅Π»ΠΈ: Π½Π΅ΠΊΡΠΎΠ· ΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·
- 5. 2. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π°
- 5. 3. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΡΡΠ°Π½ΡΠ΄ΡΠΊΡΠΈΠΈ Π°ΠΏΠΎΠΏΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠ³Π½Π°Π»Π°
- 5. 3. 1. Π ΠΎΠ»Ρ Π°Π΄Π°ΠΏΡΠΎΡΠ½ΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ» Π² Π°ΠΏΠΎΠΏΡΠΎΠ·Π΅
- 5. 3. 2. ΠΡΡΠ΅ΠΊΡΠΎΡΠ½ΡΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ: ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ, ΠΏΡΡΠΈ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΠΈ ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΎΡΠ½ΡΡ ΡΡΠ½ΠΊΡΠΈΠΉ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ Π°ΠΏΠΎΠΏΡΠΎΠ·Π°
- 5. 4. Π Π΅Π³ΡΠ»ΡΡΠΈΡ «Π°ΠΏΠΎΠΏΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ»: ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΡ ΠΈ Π°ΠΊΡΠΈΠ²Π°ΡΠΎΡΡ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΠΈ ΠΈΡ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π΄Π»Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°
Π‘Π΅Π»Π΅ΠΊΡΠΈΡ ΠΠΠ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ Π±Π΅Π»ΠΊΠ° Tag7 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΊΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ΅Π³ΠΎ Π³Π΅Π½Π° (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
ΠΠ΄Π½ΠΎΠΉ ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΎΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΡΠ²ΡΠ·Π°Π½Π½ΡΡ Ρ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ ΠΏΡΠΈΠΎΡΠΈΡΠ΅ΡΠ½ΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°.
ΠΠ·Π²Π΅ΡΡΠ½Ρ Π΄Π²Π° Π²ΠΈΠ΄Π° ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°, ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π²ΡΠΈΠ΅ΡΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠ²ΠΎΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ: Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΠΉ ΠΈ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½Π½ΡΠΉ. ΠΡΠΎΠΆΠ΄Π΅Π½Π½ΡΠΉ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅Ρ Π² ΡΠΎΠΉ ΠΈΠ»ΠΈ ΠΈΠ½ΠΎΠΉ ΡΠΎΡΠΌΠ΅ ΠΏΡΠΈΡΡΡΡΡΠ²ΡΠ΅Ρ Π²ΠΎ Π²ΡΠ΅Ρ ΠΌΠ½ΠΎΠ³ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°Ρ ΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΈΠ»ΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈ Π±ΠΎΠ»Π΅Π΅ Π΄ΡΠ΅Π²Π½Π΅ΠΉ ΡΠΈΡΡΠ΅ΠΌΠΎΠΉ, ΡΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½Π½ΡΠΉ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅Ρ, ΡΠ»ΠΎΠΆΠΈΠ²ΡΠΈΠΉΡΡ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΠ·Π΄Π½Π΅Π΅, Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠ΅Π½ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π΄Π»Ρ ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ .
ΠΡΠΈΠΎΡΠΈΡΠ΅Ρ Π² ΠΈΠ΅ΡΠ°ΡΡ ΠΈΠΈ ΠΈΠΌΠΌΡΠ½Π½ΡΡ ΡΡΠ½ΠΊΡΠΈΠΉ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΠΎ ΠΎΡΠ΄Π°Π²Π°Π»ΡΡ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½Π½ΠΎΠΌΡ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΡ. ΠΠ΄Π½Π°ΠΊΠΎ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΠΉ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅Ρ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ Π²Π°ΠΆΠ΅Π½ Π΄Π»Ρ ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ°. ΠΠΎΠ»Π΅Π΅ ΡΠΎΠ³ΠΎ, ΡΠΎΠ»ΡΠΊΠΎ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° ΠΎΠ±Π΅ΠΈΡ ΡΠΎΡΠΌ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅Ρ Π½Π°Π΄Π΅ΠΆΠ½ΡΡ Π·Π°ΡΠΈΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΠΎΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ, Π³ΡΠΈΠ±ΠΊΠΎΠ²ΠΎΠΉ, Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ ΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΉ.
ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΈ ΠΊΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π³Π΅Π½ΠΎΠ², Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½Π½ΡΡ Π² ΡΠ°Π±ΠΎΡΡ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π³Π»ΡΠ±ΠΆΠ΅ ΠΏΠΎΠ½ΡΡΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ ΡΠ°Π±ΠΎΡΡ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° Π² Π½ΠΎΡΠΌΠ΅ ΠΈ ΠΏΡΠΈΡΠΈΠ½Ρ ΡΠ±ΠΎΠ΅Π² Π² ΡΡΠΎΠΌ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ΅, Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΠ΅ Π΄Π»Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΉ.
ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«.
Π²ΡΠ²ΠΎΠ΄Ρ.
1 ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΊΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½Π° ΠΊΠΠΠ ΠΈ Π³Π΅Π½ΠΎΠΌΠ½Π°Ρ ΠΊΠΎΠΏΠΈΡ Π³Π΅Π½Π° tag7 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. Π‘ΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ°Ρ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡΠ½Π°Ρ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Π³Π΅Π½Π° tag7 ΠΏΡΠΎΡΠ²Π»ΡΠ΅Ρ Π³ΠΎΠΌΠΎΠ»ΠΎΠ³ΠΈΡ Ρ Π³Π΅Π½ΠΎΠΌ tag 7ΠΌΡΡΠΈ ΠΈ PGRP Π½Π°ΡΠ΅ΠΊΠΎΠΌΡΡ T. ni, Π° ΡΡΡΡΠΊΡΡΡΠ½Π°Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ Π³Π΅Π½Π° tag7 ΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°ΡΠΈΠ²Π½Π° Π΄Π»Ρ ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ .
2 ΠΠΎΠΊΠ°Π·Π°Π½ ΡΠ΅ΠΊΡΠ΅ΡΠΎΡΠ½ΡΠΉ Ρ Π°ΡΠ°ΠΊΡΠ΅Ρ Π±Π΅Π»ΠΊΠ° Tag7 ΠΈ Π΅Π³ΠΎ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΡ Π² Π»ΠΈΠΌΡΠΎΠΈΠ΄Π½ΡΡ ΠΊΠ»Π΅ΡΠΊΠ°Ρ . ΠΠ΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ tag7 Π² ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ ΠΊΠ»Π΅ΡΠΊΠ°Ρ .
3 ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΌΠ ΠΠ tag7 Π² Π½Π΅Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ Π»Π΅ΠΉΠΊΠΎΡΠΈΡΠ°Ρ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ Π΄ΠΎΠ½ΠΎΡΠΎΠ² ΠΈ ΠΠΠ ΠΊΠ»Π΅ΡΠΊΠ°Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π»Π΅ΠΉΠΊΠΎΡΠΈΡΠΎΠ² Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ Π²ΡΡΠΎΠΊΠΈΡ Π΄ΠΎΠ· ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π° 2 ΠΈΠ½Π΄ΡΡΠΈΡΡΠ΅Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΡΠΎΡΠΈΠ»Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ tag7.
4 ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠ΅ Π±Π΅Π»ΠΊΠ° Tag7 Π² ΡΡΠΏΠ΅ΡΠ½Π°ΡΠ°Π½ΡΠ΅ ΠΠΠ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ Π½Π° 4 ΠΈ 6 Π΄Π΅Π½Ρ ΠΈΠ½ΠΊΡΠ±Π°ΡΠΈΠΈ Π»Π΅ΠΉΠΊΠΎΡΠΈΡΠΎΠ² ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ Ρ ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½ΠΎΠΌ-2. ΠΠ°Π½Π½ΡΠΉ Π±Π΅Π»ΠΎΠΊ ΠΏΡΠΎΡΠ²Π»ΡΠ΅Ρ ΡΠΈΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ Π»ΠΈΠ½ΠΈΠΉ L929 ΠΈ Jurkat, ΠΈΠ½Π΄ΡΡΠΈΡΡΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ Π³ΠΈΠ±Π΅Π»Ρ ΠΏΠΎ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ Π°ΠΏΠΎΠΏΡΠΎΠ·Π°.
ΠΠ²ΡΠΎΡ Π²ΡΡΠ°ΠΆΠ°Π΅Ρ Π³Π»ΡΠ±ΠΎΠΊΡΡ ΠΏΡΠΈΠ·Π½Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Π‘. Π. ΠΠΈΡΠ΅Π»Π΅Π²Ρ ΠΈ Π. Π. ΠΠ½ΡΡΠ΅Π²Ρ Π·Π° ΠΏΠΎΡΡΠΎΡΠ½Π½ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΊ ΡΠ°Π±ΠΎΡΠ΅ ΠΈ Π½Π°ΡΡΠ½ΠΎΠ΅ ΡΡΠΊΠΎΠ²ΠΎΠ΄ΡΡΠ²ΠΎ. ΠΠ²ΡΠΎΡ ΡΠ°ΠΊΠΆΠ΅ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠΈΡ Π. Π. Π‘Π°ΡΠ΅Π½ΠΊΠΎ ΠΈ Π²ΡΠ΅Ρ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠΎΠ² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π΅ΡΠΈΠΊΠΈ ΡΠ°ΠΊΠ° ΠΈ Π³ΡΡΠΏΠΏΡ Π³Π΅Π½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ°ΠΊΠ° Π·Π° ΠΏΠΎΠΌΠΎΡΡ Π² ΡΠ°Π±ΠΎΡΠ΅ ΠΈ Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ. ΠΠ²ΡΠΎΡ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ΅Π½ ΠΠ»Π΅ΠΊΡΠ΅Ρ Π. ΠΠΈΠ±Π°ΡΠ΄ΠΈΠ½Ρ ΠΈ Π’Π°ΠΌΠ°ΡΠ΅ Π. ΠΡΠΊΡΡΠ½ΠΎΠ²ΠΎΠΉ Π·Π° ΠΏΠΎΠΌΠΎΡΡ ΠΈ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠ°Π±ΠΎΡΡ.
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