ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ² Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΠΠ
Π©ΡΡΠΎΠ² Π. Π., ΠΠ°ΠΊΠ°ΡΠ΅Π²ΠΈΡ Π. Π., ΠΠΎΠΏΠ°Π΅Π²Π° Π. Π., ΠΡΠ½Π΅Π²Π° Π. Π., ΠΠ΅Π²ΠΈΠ½ΡΠΊΠΈΠΉ Π. Π., ΠΠ°Π±ΠΈΠ±ΠΎΠ² Π. Π. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΠΠ-Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·ΡΡΡΠΈΡ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» Ρ Π½ΠΈΠ·ΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΌΠΈ ΡΡΠ±ΡΡΡΠ°ΡΠ°ΠΌΠΈ. 1994. ΠΠΎΠΊΠ». ΠΠΊΠ°Π΄. ΠΠ°ΡΠΊ Π ΠΠ 337(3): 407β410. Yu C.L., Huang M.H., Tsai C.Y., Tsai Y.Y., Tsai S.T., Sun K.H., Han S.H. Yu H.S. The effect of human polyclonal anti-dsDNA autoantibodies on apoptotic gene expression in cultured rat… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠΠΠΠ 1. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- 1. 1. Π Π°Π·Π²ΠΈΡΠΈΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΠΎΠ± Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΠΎΡΡΠΈ ΠΈ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π»
- 1. 1. 1. ΠΡΡΠΎΡΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΠΎΡΡΠΈ
- 1. 1. 2. Π ΠΎΠ»Ρ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» ΠΏΡΠΈ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΡ
- 1. 1. 3. ΠΡΠΈΡΠΎΠ΄Π½ΡΠ΅ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π»Π°: ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ, ΠΏΡΠΎΠΈΡΡ ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅, Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π΄Π°Π½Π½ΡΠ΅
- 1. 2. ΠΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π»Π° ΠΊ ΠΠΠ
- 1. 2. 1. ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΠΠ
- 1. 2. 2. Π‘ΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΠΠ
- 1. 2. 3. ΠΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π»Π° ΠΊ Π-ΠΠΠ ΠΈ ΠΎΠ΄Π½ΠΎΡΠ΅ΠΏΠΎΡΠ΅ΡΠ½ΠΎΠΉ ΠΠΠ
- 1. 3. ΠΡΠΈΡΠΎΠ΄Π½ΡΠ΅ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π°
- 1. 4. ΠΡΡΠΎΠ½ΡΠΈΡΠ΅Π»Π° ΠΏΡΠΈ Π»ΠΈΠΌΡΠΎΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
- 1. 1. Π Π°Π·Π²ΠΈΡΠΈΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΠΎΠ± Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΠΎΡΡΠΈ ΠΈ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π»
- ΠΠΠΠΠ 2. ΠΠΠ‘ΠΠΠ ΠΠΠΠΠ’ΠΠΠ¬ΠΠΠ― Π§ΠΠ‘Π’
- 2. 1. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ
- 2. 2. ΠΠ΅ΡΠΎΠ΄Ρ
- 2. 2. 1. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈ ΠΎΡΠΈΡΡΠΊΠ° ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ΠΎΠ² Π²
- 2. 2. 2. Π Π°Π·Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΠ°Π¬ ΠΈ ΠΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ΠΎΠ²
- 2. 2. 3. ΠΠ΅Π½Π°ΡΡΡΠΈΡΡΡΡΠΈΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π· Π² ΠΏΠΎΠ»ΠΈΠ°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄Π½ΠΎΠΌ Π³Π΅Π»Π΅ ΠΈ ΠΎΠΊΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠ°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄Π½ΡΡ Π³Π΅Π»Π΅ΠΉ
- 2. 2. 4. ΠΠΌΠΌΡΠ½ΠΎΠ±Π»ΠΎΡ
- 2. 2. 5. Π Π΅Π°ΠΊΡΠΈΡ ΡΠ΅Π»Π°ΠΊΡΠ°ΡΠΈΠΈ ΡΡΠΏΠ΅ΡΡΠΊΡΡΡΠ΅Π½Π½ΠΎΠΉ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ
- 2. 2. 6. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ
- 2. 2. 7. ΠΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π· Π² Π°Π³Π°ΡΠΎΠ·Π½ΠΎΠΌ Π³Π΅Π»Π΅
- 2. 2. 8. ΠΠ½Π°Π»ΠΈΠ· ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π°Π½ΡΠΈΡΠ΅Π» Π½Π° ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΠ΅ ΠΠΠ ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΡΠ°Π½ΡΡ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΠΠΠ Ρ Π°Π½ΡΠΈΡΠ΅Π»Π°ΠΌΠΈ
- 2. 2. 9. ΠΠ½Π°Π»ΠΈΠ· Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΠΎΡΡΠΈ ΠΠΠ-Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·ΡΡΡΠ΅ΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Ρ Π°Π½ΡΠΈΡΠ΅Π»Π°ΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π°ΡΡΠΈΠ½Π½ΠΎΠΉ ΡΠΎΡΠ±ΡΠΈΠΈ
- 2. 2. 10. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ΄Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠΊΡΠ° ΠΈ ΠΏΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠ΅ Π°ΡΡΠΈΠ½Π½ΠΎΠ³ΠΎ ΡΠΎΡΠ±Π΅Π½ΡΠ° Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π±Π΅Π»ΠΊΠΎΠ² ΡΠ΄Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠΊΡΠ°
- 2. 2. 11. ΠΡΠ»ΡΡΡΡΠ° ΡΡΠΊΠ°ΡΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ Π°Π½Π°Π»ΠΈΠ· ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ° Π°Π½ΡΠΈΡΠ΅Π»
- 2. 2. 12. ΠΠ½Π°Π»ΠΈΠ· ΡΠΈΡΠΎΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠ°ΠΊΡΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π½Π° Π½Π°Π»ΠΈΡΠΈΠ΅ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΠΠ
- 2. 2. 13. ΠΠ½Π°Π»ΠΈΠ· ΠΏΡΠΎΠ½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» Π² ΠΊΠ»Π΅ΡΠΊΡ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠ΅ΠΉ
- 2. 2. 14. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΡΡ Π±Π΅Π»ΠΊΠΎΠ² ΠΈ Π°Π½Π°Π»ΠΈΠ· ΠΊΡΠΎΡΡ-ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΠΠ-Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·ΡΡΡΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» Ρ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΡΠΌΠΈ Π±Π΅Π»ΠΊΠ°ΠΌΠΈ ΠΈ Π±Π΅Π»ΠΊΠ°ΠΌΠΈ ΡΠ΄Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠΊΡΠ°
- 3. 1. Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΡ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΠΠ ΠΈ ΡΠ²ΡΠ·Ρ ΠΠΠ-Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·ΡΡΡΠ΅ΠΉ Π°ΠΊΠΈΠ²Π½ΠΎΡΡΠΈ Ρ Π Π°Π¬-ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠΌ Π°Π½ΡΠΈΡΠ΅Π»
- 3. 2. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΡΠ°Π½ΡΡ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΠΠΠ-Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·ΡΡΡΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» Ρ ΠΠΠ
3.3. ΠΠ΅ΡΠΎΠ΄ Π°ΡΡΠΈΠ½Π½ΠΎΠΉ ΡΠΎΡΠ±ΡΠΈΠΈ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΠΠ-Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·ΡΡΡΠ΅ΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π°Π½ΡΠΈΡΠ΅Π» ΠΈ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΠΠ-Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·ΡΡΡΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ°Ρ ΠΊΡΠΎΠ²ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ ΠΊΡΠ°ΡΠ½ΠΎΠΉ Π²ΠΎΠ»ΡΠ°Π½ΠΊΠΎΠΉ (Π‘ΠΠ) ΠΈ Π»ΠΈΠΌΡΠΎΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ.
3.4. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΠΠ-Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·ΡΡΡΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» Ρ Π±Π΅Π»ΠΊΠ°ΠΌΠΈ ΡΠ΄Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠΊΡΠ°.
3.5 Π¦ΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΠΠ.
ΠΠΠΠΠ 4. ΠΠ«ΠΠΠΠ«.
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ² Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΠΠ (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ Π΄Π΅ΡΡΡΠΈΠ»Π΅ΡΠΈΠΉ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ°ΡΡΠΈΡΠΈΠ»ΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΎΠ² ΠΈ ΠΌΠ΅Π΄ΠΈΠΊΠΎΠ² ΠΎ ΡΠ²ΠΎΠΉΡΡΠ²Π°Ρ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π». ΠΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΠ΅ ΡΡΠΈΡ Π°Π½ΡΠΈΡΠ΅Π», ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΡ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡΡ ΡΠ²ΡΠ·ΡΠ²Π°ΡΡ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΠ΅ Π°Π½ΡΠΈΠ³Π΅Π½Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°, ΠΊΠ°ΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, ΡΠΎΠΏΡΡΠΆΠ΅Π½ΠΎ Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΡΠ΅Π»ΠΎΠ³ΠΎ ΡΡΠ΄Π° ΡΡΠΆΠ΅Π»Π΅ΠΉΡΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΏΠΎΠ»ΡΡΠΈΠ²ΡΠΈΡ Π½Π°Π·Π²Π°Π½ΠΈΠ΅ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΡ . ΠΡΠΎΠΌΠ°Π΄Π½ΠΎΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΡΠΎΡΠ½ΠΎ ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ ΡΠ²ΡΠ·Ρ ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΡ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, Π° Π² ΡΡΠ΄Π΅ ΡΠ»ΡΡΠ°Π΅Π² ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ ΠΈ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ ΠΈΡ ΡΡΠ°ΡΡΠΈΡ Π² ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ΅.
ΠΡΠΈΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΠ½ΠΎ, ΡΡΠΎ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π»Π° ΠΎΠ±Π½Π°ΡΡΠΆΠΈΠ²Π°ΡΡΡΡ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΠΏΡΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ ΡΠΈΡΡΠΎ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΠΏΡΠΈΡΠΎΠ΄Ρ. ΠΠΎΠ²ΡΡΠ΅Π½Π½ΡΠΉ ΡΡΠΎΠ²Π΅Π½Ρ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΠΏΡΠΈ ΡΡΠ΄Π΅ Π»ΠΈΠΌΡΠΎΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΏΡΠΈΡΠΎΠ΄Ρ (Π‘ΠΠΠ, Π³Π΅ΠΏΠ°ΡΠΈΡΡ), ΠΈ Π² ΡΡΠΎΠΌ ΡΠ»ΡΡΠ°Π΅ ΠΎΠ½ΠΈ, Π±Π΅Π·ΡΡΠ»ΠΎΠ²Π½ΠΎ, ΡΠ°ΠΊΠΆΠ΅ Π²Π½ΠΎΡΡΡ ΡΠ²ΠΎΠΉ Π²ΠΊΠ»Π°Π΄ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°. ΠΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌΠΈ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π° Π»ΠΈΠΌΡΠΎΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π² ΡΠΎΠΉ ΠΈΠ»ΠΈ ΠΈΠ½ΠΎΠΉ ΠΌΠ΅ΡΠ΅ ΡΠ²Π»ΡΡΡΡΡ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» ΠΏΡΠΈ ΡΡΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ Π²ΠΏΠΎΠ»Π½Π΅ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΎ, ΠΎΠ΄Π½Π°ΠΊΠΎ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΠ΅ ΠΏΡΠΈΡΠΈΠ½Ρ, Π²ΡΠ·ΡΠ²Π°ΡΡΠΈΠ΅ ΡΠΎΠΏΡΡΠΆΠ΅Π½Π½ΡΠΉ Ρ Π»ΠΈΠΌΡΠΎΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ΅ΠΉ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΠΉ ΠΏΡΠΎΡΠ΅ΡΡ, Π΅ΡΠ΅ Π½Π΅ Π²ΡΡΡΠ½Π΅Π½Ρ ΠΈ ΡΡΠ΅Π±ΡΡΡ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ² Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» ΠΈ Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΈΡ ΡΠΎΠ»ΠΈ ΠΏΡΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ Π»ΠΈΠΌΡΠΎΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ ΠΎΡΠΊΡΡΠ²Π°ΡΡ ΡΠΈΡΠΎΠΊΠΈΠ΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ Π΄Π»Ρ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΡΡΠΈΡ ΠΏΡΠΈΡΠΈΠ½ ΠΈ ΠΌΠΎΠ³ΡΡ Π²Π½Π΅ΡΡΠΈ ΡΠ²ΠΎΠΉ Π²ΠΊΠ»Π°Π΄ Π² ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΡ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ΠΎΠ² ΠΊ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ ΠΊΡΠΎΠ²ΠΈ. Π‘ Π΄ΡΡΠ³ΠΎΠΉ ΡΡΠΎΡΠΎΠ½Ρ, Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ², ΠΏΡΠΈΡΠΈΠ½Π°Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°Ρ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» ΠΏΠΎΠΌΠΎΠ³Π°ΡΡ ΠΏΠΎΠ½ΡΡΡ Π±Π°Π·ΠΎΠ²ΡΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π·Π΄ΠΎΡΠΎΠ²ΠΎΠΉ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈ Π΅Π΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΡΠ°Π±ΠΎΡΡ Π΄ΡΡΠ³ΠΈΡ ΡΠΈΡΡΠ΅ΠΌ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°.
ΠΠ³ΡΠΎΠΌΠ½ΠΎΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Π½ΠΎΠ²ΡΡ Π΄Π°Π½Π½ΡΡ ΠΏΠΎΡΠ²ΠΈΠ»ΠΎΡΡ Π² ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ ΠΎ ΡΠ°Π½Π΅Π΅ Π½Π΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ²Π°Ρ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π». ΠΡΠ»ΠΎ Π²ΡΡΡΠ½Π΅Π½ΠΎ, ΡΡΠΎ Π½Π΅ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΡΠΈΡΠΎΠ΄Π½ΡΠ΅ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π»Π° ΡΠΏΠΎΡΠΎΠ±Π½Ρ ΠΏΡΠΎΡΠ²Π»ΡΡΡ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌ ΡΡΠ±ΡΡΡΠ°ΡΠ°ΠΌ, ΡΠ°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΠΎΠ½ΠΈ ΠΊΠ°ΠΊ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ Π·Π°Π΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°Π½Ρ Π² Π΄Π΅Π³ΡΠ°Π΄Π°ΡΠΈΠΈ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΡΠ°ΡΠΏΠ°Π΄Π° ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΡΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ΅, ΡΠ°ΠΊ ΠΈ Π½Π°Π½ΠΎΡΠΈΡΡ ΡΠ΅ΡΡΠ΅Π·Π½ΡΠΉ Π²ΡΠ΅Π΄ ΠΆΠΈΠ²ΡΠΌ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌ ΠΈ ΡΠΊΠ°Π½ΡΠΌ, ΠΏΡΠΎΠ²ΠΎΡΠΈΡΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ. Π ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, ΡΡΠ΄ ΡΠ°Π±ΠΎΡ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΠΠ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π²ΡΡΠΊΠ°Π·Π°ΡΡ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ ΠΎ ΠΈΡ Π³ΠΎΡΠ°Π·Π΄ΠΎ Π±ΠΎΠ»ΡΡΠ΅ΠΌ, ΡΠ΅ΠΌ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π»ΠΎΡΡ ΡΠ°Π½Π΅Π΅, Π·Π½Π°ΡΠ΅Π½ΠΈΠΈ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°. Π ΡΡΠΎΠΌ ΠΏΠ»Π°Π½Π΅ ΠΊΡΠ°ΠΉΠ½Π΅ Π»ΡΠ±ΠΎΠΏΡΡΠ½Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΠΏΠΎΠΊΠ°Π·Π°Π²ΡΠΈΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΠΠ Π² ΠΊΠ»Π΅ΡΠΊΡ Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠ΅ΠΉ Π² ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΌ ΡΠ΄ΡΠ΅. ΠΡΠΈ Π΄Π°Π½Π½ΡΠ΅ Π΄Π°ΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΡΡΡΠΎΠΈΡΡ Π³ΠΈΠΏΠΎΡΠ΅Π·Ρ ΠΎ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΎΠ»ΠΈ Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» Π² ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΠΆΠΈΠ·Π½Π΅Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ.
ΠΡΠ΅ ΡΡΠΈ ΡΠ°Π½Π΅Π΅ Π½Π΅ ΠΎΡΠΌΠ΅ΡΠ΅Π½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» ΡΡΠ΅Π±ΡΡΡ ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π³ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΠΎΠ½ΠΈ ΠΌΠΎΠ³ΡΡ ΠΈΠΌΠ΅ΡΡ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ Π² ΠΏΠ»Π°Π½Π΅ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ Π½Π°ΡΡΠ½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, Π½ΠΎ ΠΈ Π½Π°ΠΉΡΠΈ ΡΠΈΡΠΎΠΊΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠ°ΠΊ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΡΠΎΠΏΡΡΠΆΠ΅Π½Π½ΡΡ Ρ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½ΡΠΌΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΡΠΌΠΈ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, ΠΌΠ½ΠΎΠ³ΠΈΡ ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ ΠΊΡΠΎΠ²ΠΈ, ΡΠ°ΠΊ ΠΈ Π² ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ Π½ΠΎΠ²ΡΡ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ΠΎΠ² ΠΊ ΠΈΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ.
ΠΡΠ΅Π΄ΠΌΠ΅ΡΠΎΠΌ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΠ΅ ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ²ΠΎΠΉΡΡΠ² Π°ΡΡΠΎΠ°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΠΠ ΠΏΡΠΈ Π»ΠΈΠΌΡΠΎΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΡ ΠΈ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ , ΠΏΠΎΠΈΡΠΊ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠ², Π²ΡΠ·ΡΠ²Π°ΡΡΠΈΡ ΠΈΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅, ΠΈ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΠΈ, ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π±ΡΡΡΡΠΎΠ³ΠΎ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³Π° ΠΈ Π΄Π΅ΡΠ΅ΠΊΡΠΈΠΈ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΠΠ.
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