Π‘ΡΡΡΠΊΡΡΡΠ° ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² Π±ΡΡΡΡ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ ΠΌΠΎΡΠ΅ΠΉ ΠΠ°Π»ΡΠ½Π΅Π³ΠΎ ΠΠΎΡΡΠΎΠΊΠ° Π ΠΎΡΡΠΈΠΈ
ΠΡΡΡΠ΅ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»ΠΈ (Π Π¬Π°ΡΠΎΡΠ¬Ρ1Π°), ΡΠΈΠΏ ΡΠΏΠΎΡΠΎΠ²ΡΡ ΡΠ°ΡΡΠ΅Π½ΠΈΠΉ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠΈΠΉ 240 ΡΠΎΠ΄ΠΎΠ² (Π±ΠΎΠ»Π΅Π΅ 1500 Π²ΠΈΠ΄ΠΎΠ²), ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ 3 — ΠΏΡΠ΅ΡΠ½ΠΎΠ²ΠΎΠ΄Π½ΡΠ΅, ΠΎΡΡΠ°Π»ΡΠ½ΡΠ΅ — ΠΌΠΎΡΡΠΊΠΈΠ΅. ΠΡΠΈ ΠΌΠ°ΠΊΡΠΎΠ²ΠΎΠ΄ΠΎΡΠΎΡΠ»ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ ΡΠΈΡΠΎΠΊΠΎ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Ρ Π² Ρ ΠΎΠ»ΠΎΠ΄Π½ΡΡ ΡΠ°ΡΡΡΡ ΠΡΠ»Π°Π½ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ Π’ΠΈΡ ΠΎΠ³ΠΎ ΠΎΠΊΠ΅Π°Π½ΠΎΠ², Π³Π΄Π΅ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°ΡΡ Π²ΠΈΠ΄Ρ, ΠΎΡΠ½ΠΎΡΡΡΠΈΠ΅ΡΡ ΠΊ ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π°ΠΌ Π ΠΈΡΠ°ΡΠ΅Π°Π΅ ΠΈ Π¬Π°ΠΏΠ½ΠΏΠ°ΠΏΠΏΠ°ΡΠ΅Π°Π΅. Π ΡΠ΅ΠΏΠ»ΡΡ Π²ΠΎΠ΄Π°Ρ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Ρ Π±ΡΡΡΠ΅ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»ΠΈ ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° 8Π°Π³§ Π°88Π°ΡΠ΅Π°Π΅… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- 2. ΠΠΠ’ΠΠ ΠΠ’Π£Π ΠΠ«Π ΠΠΠΠΠ
- 2. 1. Π€ΡΠΊΠΎΠΈΠ΄Π°Π½Ρ Π±ΡΡΡΡ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ. ΠΠ±ΡΠΈΠ΅ ΡΠ²Π΅Π΄Π΅Π½ΠΈΡ
- 2. 2. Π‘ΡΡΡΠΊΡΡΡΠ½ΡΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² Π±ΡΡΡΡ
Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ
- 2. 2. 1. Π€ΡΠΊΠΎΠΈΠ΄Π°Π½Ρ, ΠΏΠΎΡΡΡΠΎΠ΅Π½Π½ΡΠ΅ ΠΈΠ· 1—^3-ΡΠ²ΡΠ·Π°Π½Π½ΡΡ ΠΎΡΡΠ°ΡΠΊΠΎΠ² ΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π°- Π¬-ΡΡΠΊΠΎΠΏΠΈΡΠ°Π½ΠΎΠ·Ρ
- 2. 2. 2. Π€ΡΠΊΠΎΠΈΠ΄Π°Π½Ρ, ΠΏΠΎΡΡΡΠΎΠ΅Π½Π½ΡΠ΅ ΠΈΠ· 1—>3- ΠΈ 1—>4-ΡΠ²ΡΠ·Π°Π½Π½ΡΡ ΠΎΡΡΠ°ΡΠΊΠΎΠ² ΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π°-Π¬-ΡΡΠΊΠΎΠΏΠΈΡΠ°Π½ΠΎΠ·Ρ
- 2. 2. 3. Π€ΡΠΊΠΎΠΈΠ΄Π°Π½Ρ, ΠΏΠΎΡΡΡΠΎΠ΅Π½Π½ΡΠ΅ ΠΈΠ· 1—>3 ΠΈ/ΠΈΠ»ΠΈ 1—Π-ΡΠ²ΡΠ·Π°Π½Π½ΡΡ ΠΎΡΡΠ°ΡΠΊΠΎΠ² ΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π°-Π¬-ΡΡΠΊΠΎΠΏΠΈΡΠ°Π½ΠΎΠ·Ρ ΠΈ Ρ-Π-Π³Π°Π»Π°ΠΊΡΠΎΠΏΠΈΡΠ°Π½ΠΎΠ·Ρ
- 2. 2. 4. Π€ΡΠΊΠΎΠΈΠ΄Π°Π½Ρ ΡΠ»ΠΎΠΆΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π°
- 2. 3. ΠΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² Π±ΡΡΡΡ
Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ
- 2. 3. 1. ΠΠ½ΡΠΈΠΊΠΎΠ°Π³ΡΠ»ΡΠ½ΡΠ½Π°Ρ ΠΈ Π°Π½ΡΠΈΡΡΠΎΠΌΠ±ΠΈΡΠ΅ΡΠΊΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ
- 2. 3. 2. ΠΠ½ΡΠΈΠ²ΠΈΡΡΡΠ½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ
- 2. 3. 3. ΠΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ
- 2. 3. 3. 1. ΠΠ½ΡΠΈΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ
- 2. 3. 3. 2. ΠΠ½ΡΠΈΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ
- 2. 3. 4. ΠΠΏΠΎΠΏΡΠΎΠ·
- 2. 3. 4. 1. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ½ΡΡΠΈΡ «Π°ΠΏΠΎΠΏΡΠΎΠ·». ΠΡΠ»ΠΈΡΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π°
- 2. 3. 4. 2. Π‘ΠΈΠ³Π½Π°Π»ΡΠ½ΡΠ΅ ΠΏΡΡΠΈ ΠΏΡΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π΅
- 2. 3. 4. 3. ΠΠΈΡΠΎΠ³Π΅Π½-Π°ΠΊΡΠΈΠ²ΠΈΡΡΠ΅ΠΌΡΠ΅ ΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΊΠΈΠ½Π°Π·Π½ΡΠ΅ ΠΊΠ°ΡΠΊΠ°Π΄Ρ
- 2. 3. 4. 4. Π€ΡΠΊΠΎΠΈΠ΄Π°Π½Ρ Π±ΡΡΡΡ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ — ΠΈΠ½Π΄ΡΠΊΡΠΎΡΡ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΡΠ°ΠΊΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ
- 3. 1. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² ΠΈΠ· Π±ΡΡΡΡ
Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ ΠΈ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΠΈΡ
ΡΡΡΡΠΊΡΡΡΡ
- 3. 1. 1. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈ ΡΡΠ°ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² ΠΈΠ· Π±ΡΡΡΡ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ
- 3. 1. 2. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΡΡΠΊΡΡΡΡ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ²
- 3. 2. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² ΠΈΠ· Π±ΡΡΡΡ
Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ
- 3. 2. 1. Π¦ΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ²
- 3. 2. 2. ΠΠ΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² Π½Π° ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΡ ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ
- 3. 2. 3. ΠΠ΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² Π½Π° Π½Π΅ΠΎΠΏΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΡΡ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ, Π²ΡΠ·Π²Π°Π½Π½ΡΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΠΠ²Π
- 3. 2. 3. 1. ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΉ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ ΠΊΠ°Π½ΡΠ΅ΡΠΏΡΠ΅Π²Π΅Π½ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΡΠΊΠΎΠΈΠ΄Π°Π½Π° ΠΈΠ· Π±ΡΡΠΎΠΉ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»ΠΈ & ΡΠ³ΡΠΊΠΎΠΏΠΎΠ³Ρ^Π΅Ρ
- 3. 2. 4. ΠΠ΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² Π½Π° ΡΠ°ΠΌΠΎΠΏΡΠΎΠΈΠ·Π²ΠΎΠ»ΡΠ½ΠΎΠ΅ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠΎΠ»ΠΎΠ½ΠΈΠΉ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ
- 3. 2. 4. 1. ΠΠ΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΡΠΊΠΎΠΈΠ΄Π°Π½Π° ΠΈΠ· Π±ΡΡΠΎΠΉ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»ΠΈ Π. Π΅ΡΠ°ΠΏΠ΅Π·ΡΠ΅ΠΏΡ Π½Π° Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΌΠ°ΡΡΠΈΠΊΡΠ½ΡΡ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½Π°Π·
- 3. 2. 5. ΠΡΠΎΠ°ΠΏΠΎΠΏΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΡΠΊΠΎΠΈΠ΄Π°Π½Π° ΠΈΠ· Π±ΡΡΠΎΠΉ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»ΠΈ & Π«ΡΠΊΠΎΠ³ΡΡΠ΅Π·
- 4. 1. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ
- 4. 2. ΠΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΠ΅
- 4. 3. ΠΠ΅ΡΠΎΠ΄Ρ
Π‘ΡΡΡΠΊΡΡΡΠ° ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² Π±ΡΡΡΡ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ ΠΌΠΎΡΠ΅ΠΉ ΠΠ°Π»ΡΠ½Π΅Π³ΠΎ ΠΠΎΡΡΠΎΠΊΠ° Π ΠΎΡΡΠΈΠΈ (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
ΠΡΡΡΠ΅ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»ΠΈ ΠΌΠΎΡΠ΅ΠΉ ΠΠ°Π»ΡΠ½Π΅Π³ΠΎ ΠΠΎΡΡΠΎΠΊΠ° Π ΠΎΡΡΠΈΠΈ ΡΠ²Π»ΡΡΡΡΡ Π±ΠΎΠ³Π°ΡΡΠΌ, Π»Π΅Π³ΠΊΠΎ Π²ΠΎΠ·ΠΎΠ±Π½ΠΎΠ²Π»ΡΠ΅ΠΌΡΠΌ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠΌ ΡΠ½ΠΈΠΊΠ°Π»ΡΠ½ΡΡ ΠΏΠΎ ΡΡΡΡΠΊΡΡΡΠ΅ ΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌ ΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄ΠΎΠ² (Π»Π°ΠΌΠΈΠ½Π°ΡΠ°Π½ΠΎΠ², Π°Π»ΡΠ³ΠΈΠ½ΠΎΠ²ΡΡ ΠΊΠΈΡΠ»ΠΎΡ ΠΈ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ²). Π ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠΌ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ°Π»ΠΈ ΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄Ρ Π±ΡΡΡΡ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ — ΡΡΠΊΠΎΠΈΠ΄Π°Π½Ρ. ΠΠ½ΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΡΠΎΠ±ΠΎΠΉ ΠΎΠ±ΡΠΈΡΠ½ΡΠΉ ΠΊΠ»Π°ΡΡ Π±ΠΈΠΎΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΈ ΡΡΡΡΠΊΡΡΡΠ° ΠΊΠΎΡΠΎΡΡΡ Π²Π°ΡΡΠΈΡΡΠ΅Ρ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π²ΠΈΠ΄Π° Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»ΠΈ, ΠΌΠ΅ΡΡ Π΅Π΅ ΠΏΡΠΎΠΈΠ·ΡΠ°ΡΡΠ°Π½ΠΈΡ, ΡΠ΅Π·ΠΎΠ½Π° ΡΠ±ΠΎΡΠ° ΠΈ ΠΌΠ½ΠΎΠ³ΠΈΡ Π΄ΡΡΠ³ΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ². ΠΠΎΡΡΠΎΡΠ½Π½ΠΎ ΡΠ°ΡΡΡΡΠΈΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΊ ΡΡΠΈΠΌ ΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄Π°ΠΌ ΠΎΠ±ΡΡΡΠ½ΡΠ΅ΡΡΡ ΠΈΡ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎΠΉ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π° ΠΏΡΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΡ.
Π ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΡΡΡΠ΅ΠΌΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΡΠΎΡΡ ΡΠΈΡΠ»Π° ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ². ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π΄Π°Π½Π½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π΅Ρ Ρ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΠΎΠ΄Π½Π°ΠΊΠΎ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠΈ Π½Π° ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π΄ΡΡΠ³ΠΈΡ ΡΡΡΡΠΊΡΡΡΠ½ΡΡ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ: ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ ΡΡΠ»ΡΡΠ°ΡΠ½ΡΡ Π³ΡΡΠΏΠΏ Π² ΠΌΠΎΠ½ΠΎΡΠ°Ρ Π°ΡΠΈΠ΄Π½ΡΡ ΠΎΡΡΠ°ΡΠΊΠ°Ρ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ², ΠΈΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΡ, ΡΠΈΠΏΠ° Π-Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ΄Π½ΠΎΠΉ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΡΡΠ°ΡΠΊΠ°ΠΌΠΈ ΡΡΠΊΠΎΠ·Ρ ΠΈ/ΠΈΠ»ΠΈ Π΄ΡΡΠ³ΠΈΡ ΠΌΠΎΠ½ΠΎΡΠ°Ρ Π°ΡΠΈΠ΄ΠΎΠ² Π² Π³Π»Π°Π²Π½ΠΎΠΉ ΡΠ΅ΠΏΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ Π½Π°Π»ΠΈΡΠΈΠ΅ Π½Π΅ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΡΡ Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Π΅ΠΉ, ΠΎΡΡΡΡΡΡΠ²ΡΠ΅Ρ.
ΠΠΊΡΡΠ°Π»ΡΠ½ΡΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² ΡΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΠΌΠΈ ΡΡΡΡΠΊΡΡΡΠ½ΡΠΌΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ ΠΈ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ° ΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ², ΠΏΡΠΈΠ½Π°Π΄Π»Π΅ΠΆΠ°ΡΠΈΡ ΠΊ ΡΠ°Π·Π½ΡΠΌ ΡΡΡΡΠΊΡΡΡΠ½ΡΠΌ ΡΠΈΠΏΠ°ΠΌ, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ Π²ΡΡΠ²ΠΈΡΡ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΈΡ ΡΡΡΡΠΊΡΡΡΠ½ΡΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ.
Π¦Π΅Π»ΡΡ Π΄Π°Π½Π½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΡΡΠΊΡΡΡΡ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² Π±ΡΡΡΡ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ ΠΌΠΎΡΠ΅ΠΉ ΠΠ°Π»ΡΠ½Π΅Π³ΠΎ ΠΠΎΡΡΠΎΠΊΠ° Π ΠΎΡΡΠΈΠΈ Saccharina cichorioides, Saccharina japonica, Fucus evanescens ΠΈ Undaria pinnatifida ΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΡΡΡΡΠΊΡΡΡΡ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² ΠΈ ΠΈΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΡΠΈΠΏΡ ΡΠ°ΠΊΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°.
2. ΠΠΠ’ΠΠ ΠΠ’Π£Π ΠΠ«Π ΠΠΠΠΠ .
ΠΡΡΡΠ΅ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»ΠΈ (Π Π¬Π°ΡΠΎΡΠ¬Ρ1Π°), ΡΠΈΠΏ ΡΠΏΠΎΡΠΎΠ²ΡΡ ΡΠ°ΡΡΠ΅Π½ΠΈΠΉ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠΈΠΉ 240 ΡΠΎΠ΄ΠΎΠ² (Π±ΠΎΠ»Π΅Π΅ 1500 Π²ΠΈΠ΄ΠΎΠ²), ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ 3 — ΠΏΡΠ΅ΡΠ½ΠΎΠ²ΠΎΠ΄Π½ΡΠ΅, ΠΎΡΡΠ°Π»ΡΠ½ΡΠ΅ — ΠΌΠΎΡΡΠΊΠΈΠ΅. ΠΡΠΈ ΠΌΠ°ΠΊΡΠΎΠ²ΠΎΠ΄ΠΎΡΠΎΡΠ»ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ ΡΠΈΡΠΎΠΊΠΎ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Ρ Π² Ρ ΠΎΠ»ΠΎΠ΄Π½ΡΡ ΡΠ°ΡΡΡΡ ΠΡΠ»Π°Π½ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ Π’ΠΈΡ ΠΎΠ³ΠΎ ΠΎΠΊΠ΅Π°Π½ΠΎΠ², Π³Π΄Π΅ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°ΡΡ Π²ΠΈΠ΄Ρ, ΠΎΡΠ½ΠΎΡΡΡΠΈΠ΅ΡΡ ΠΊ ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π°ΠΌ Π ΠΈΡΠ°ΡΠ΅Π°Π΅ ΠΈ Π¬Π°ΠΏΠ½ΠΏΠ°ΠΏΠΏΠ°ΡΠ΅Π°Π΅. Π ΡΠ΅ΠΏΠ»ΡΡ Π²ΠΎΠ΄Π°Ρ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Ρ Π±ΡΡΡΠ΅ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»ΠΈ ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° 8Π°Π³§ Π°88Π°ΡΠ΅Π°Π΅. Π‘Π»ΠΎΠ΅Π²ΠΈΡΠ° Π±ΡΡΡΡ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ ΠΈΠΌΠ΅ΡΡ ΡΠ²Π΅Ρ ΠΎΡ ΠΎΠ»ΠΈΠ²ΠΊΠΎΠ²ΠΎ-Π·Π΅Π»ΡΠ½ΠΎΠ³ΠΎ Π΄ΠΎ ΡΠ΅ΠΌΠ½ΠΎ-Π±ΡΡΠΎΠ³ΠΎ ΠΈΠ·-Π·Π° ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΡ Π² Ρ ΡΠΎΠΌΠ°ΡΠΎΡΠΎΡΠ°Ρ ΠΎΡΠΎΠ±ΠΎΠ³ΠΎ Π±ΡΡΠΎΠ³ΠΎ ΠΏΠΈΠ³ΠΌΠ΅Π½ΡΠ° ΡΡΠΊΠΎΠΊΡΠ°Π½ΡΠΈΠ½Π°, ΠΌΠ°ΡΠΊΠΈΡΡΡΡΠ΅Π³ΠΎ Π΄ΡΡΠ³ΠΈΠ΅ ΠΏΠΈΠ³ΠΌΠ΅Π½ΡΡ (Ρ Π»ΠΎΡΠΎΡΠΈΠ»Π», Ρ Π»ΠΎΡΠΎΡΠΈΠ»Π» Ρ, ΠΊΡΠ°Π½ΡΠΎΡΠΈΠ»Π» ΠΈ Π±Π΅ΡΠ°-ΠΊΠ°ΡΠΎΡΠΈΠ½). ΠΡΡΡΠ΅ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»ΠΈ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·Π½Ρ ΠΏΠΎ ΡΠΎΡΠΌΠ΅ ΠΈ ΡΠ°Π·ΠΌΠ΅ΡΠ°ΠΌ (ΠΎΡ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ°Π·Π²Π΅ΡΠ²Π»Π΅Π½Π½ΡΡ Π½ΠΈΡΠ΅ΠΉ Π΄ΠΎ 40 ΠΌΠ΅ΡΡΠΎΠ²ΡΡ ΡΠ°ΡΡΠ΅Π½ΠΈΠΉ).
ΠΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄Ρ ΡΠ²Π»ΡΡΡΡΡ Π³Π»Π°Π²Π½ΡΠΌΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°ΠΌΠΈ Π±ΠΈΠΎΠΌΠ°ΡΡΡ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ ΠΈ Π²ΡΠΏΠΎΠ»Π½ΡΡΡ ΡΡΠ΄ Π²Π°ΠΆΠ½Π΅ΠΉΡΠΈΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΉ: ΡΠ»ΡΠΆΠ°Ρ ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠ΅Π·Π΅ΡΠ²ΠΎΠΌ, ΡΡΠ°ΡΡΠ²ΡΡΡ Π² ΠΏΠΎΡΡΡΠΎΠ΅Π½ΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΡΡΠ΅Π½ΠΎΠΊ, ΠΎΠ±ΡΠ°Π·ΡΡΡ Π½Π°ΡΡΠΆΠ½ΡΠ΅ ΠΊΠ°ΠΏΡΡΠ»Ρ ΠΈ ΠΌΠ΅ΠΆΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΠΌΠ°ΡΡΠΈΠΊΡ, ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΡΡΡ Π΄Π΅Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ, ΡΠΎΠ·Π΄Π°ΡΡ Π±Π°ΡΡΠ΅Ρ Π΄Π»Ρ ΠΏΡΠΎΠ½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ Π² ΠΊΠ»Π΅ΡΠΊΠΈ ΡΠΎΠ»Π΅ΠΉ ΠΈΠ· ΠΌΠΎΡΡΠΊΠΎΠΉ Π²ΠΎΠ΄Ρ ΠΈΠ»ΠΈ, Π½Π°ΠΏΡΠΎΡΠΈΠ², ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡ ΠΈΠ·Π±ΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΏΠΎΠ³Π»ΠΎΡΠ΅Π½ΠΈΠ΅ ΠΊΠ°ΡΠΈΠΎΠ½ΠΎΠ², Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡΡ Π΄Π»Ρ ΠΏΠΎΡΡΡΠΎΠ΅Π½ΠΈΡ ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΊΠ΅Π»Π΅ΡΠ°.
ΠΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄Ρ ΠΈΠΌΠ΅ΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΡΡΡΠΊΡΡΡΡ ΠΈ ΠΈΠ½ΡΡΠΈΠ³ΡΡΡΠΈΠΉ ΡΠΏΠ΅ΠΊΡΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΠΌΠΈ ΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄Π°ΠΌΠΈ Π±ΡΡΡΡ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ ΡΠ²Π»ΡΡΡΡΡ Π°Π»ΡΠ³ΠΈΠ½ΠΎΠ²ΡΠ΅ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΈ ΠΈΡ ΡΠΎΠ»ΠΈ, Π»Π°ΠΌΠΈΠ½Π°ΡΠ°Π½Ρ (1—>3- ΠΈΠ»ΠΈ 1 —>3- 1 —>6-Ρ-0-Π³Π»ΡΠΊΠ°Π½Ρ) ΠΈ ΡΡΠΊΠΎΠΈΠ΄Π°Π½Ρ (ΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π°-Π¬-ΡΡΠΊΠ°Π½Ρ ΠΈΠ»ΠΈ Π³Π΅ΡΠ΅ΡΠΎΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄Ρ). Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠΈΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ Π²ΡΠ·ΡΠ²Π°ΡΡ ΡΡΠΊΠΎΠΈΠ΄Π°Π½Ρ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½Ρ Π΄Π»Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π½Π° ΠΈΡ ΠΎΡΠ½ΠΎΠ²Π΅ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ Π΄ΠΎΠ±Π°Π²ΠΎΠΊ ΠΈ Π»Π΅ΠΊΠ°ΡΡΡΠ², Π½Π΅ΡΠΌΠΎΡΡΡ Π½Π° ΡΡΡΠ΄Π½ΠΎΡΡΠΈ Ρ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΈΡ ΡΡΡΡΠΊΡΡΡΡ.
5. ΠΠ«ΠΠΠΠ«.
1. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΡΠΊΠΎΠΈΠ΄Π°Π½Ρ ΠΈΠ· Π±ΡΡΡΡ Π²ΠΎΠ΄ΠΎΡΠΎΡΠ»Π΅ΠΉ Saccharina cichorioides, S. japonica, Fucus evanescens ΠΈ Undaria pinnatijida ΠΎΡΠ»ΠΈΡΠ°ΡΡΡΡ ΠΏΠΎ ΠΌΠΎΠ½ΠΎΡΠ°Ρ Π°ΡΠΈΠ΄Π½ΠΎΠΌΡ ΡΠΎΡΡΠ°Π²Ρ, ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ Π°ΡΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. Π€ΡΠΊΠΎΠΈΠ΄Π°Π½ ΠΈΠ· S. cichorioides ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ Π²ΡΡΠΎΠΊΠΎΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ 1—"Π-Π°-Π¬-ΡΡΠΊΠ°Π½ΡΡΠΊΠΎΠΈΠ΄Π°Π½ ΠΈΠ· F. evanescens ΡΠΎΡΡΠΎΠΈΡ ΠΈΠ· 1—>3- ΠΈ 1—>4-ΡΠ²ΡΠ·Π°Π½Π½ΡΡ ΠΎΡΡΠ°ΡΠΊΠΎΠ² a-L-ΡΡΠΊΠΎΠ·Ρ, ΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΏΠΎ Π‘2 ΠΈ ΠΌΠ΅Π½Π΅Π΅ ΠΏΠΎ Π‘4 ΠΈ Π°ΡΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΏΠΎ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΠΌ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡΠΌ.
2. ΠΠ°Π»Π°ΠΊΡΠΎΡΡΠΊΠ°Π½Ρ ΠΈΠ· S. japonica ΠΈ U. pinnatifida ΠΏΠΎΡΡΡΠΎΠ΅Π½Ρ ΠΈΠ· 1—>3-ΡΠ²ΡΠ·Π°Π½Π½ΡΡ ΠΈ 1—>3- ΠΈ 14-ΡΠ²ΡΠ·Π°Π½Π½ΡΡ ΠΎΡΡΠ°ΡΠΊΠΎΠ² a-L-ΡΡΠΊΠΎΠ·Ρ ΠΈ p-D-Π³Π°Π»Π°ΠΊΡΠΎΠ·Ρ, ΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΏΠΎ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡΠΌ Π‘2 ΠΈ ΠΌΠ΅Π½Π΅Π΅ Π‘4, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ°ΡΡΠΈΡΠ½ΠΎ Π°ΡΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΏΠΎ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΠΌ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡΠΌ.
3. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΠΊΠΎΠΈΠ΄Π°Π½Ρ Π½Π΅ ΡΠΎΠΊΡΠΈΡΠ½Ρ ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ ΡΠΏΠΈΠ΄Π΅ΡΠΌΠ°Π»ΡΠ½ΡΠΌ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌ ΠΌΡΡΠΈ JB6 Π‘141 ΠΈ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΡΡ ΠΈΡ EGF-ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ Π½Π΅ΠΎΠΏΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΡΡ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ.
4. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ ΠΈΠ· S. cichorioides Π±Π»ΠΎΠΊΠΈΡΡΠ΅Ρ EGF-ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ JB6 Π‘141 ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ EGFR, ΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΊΠΈΠ½Π°Π· ΠΠΠ Π ΠΊΠ°ΡΠΊΠ°Π΄Π° ΠΈ ΠΠ -1 ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°.
5. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΠΊΠΎΠΈΠ΄Π°Π½Ρ Π½Π΅Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π²Π»ΠΈΡΡΡ Π½Π° ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΡ ΡΠ°ΠΊΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, Π½ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΡΡ ΡΠ°ΠΌΠΎΠΏΡΠΎΠΈΠ·Π²ΠΎΠ»ΡΠ½ΠΎΠ΅ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΡΠΎΡΡ ΠΊΠΎΠ»ΠΎΠ½ΠΈΠΉ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ°ΠΊΠ° ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ°, ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΠΈ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΠΈΠ·Π±ΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ², ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½Π°Ρ ΠΈΡ ΡΡΡΡΠΊΡΡΡΠ½ΡΠΌΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ.
6. Π€ΡΠΊΠΎΠΈΠ΄Π°Π½ ΠΈΠ· F. evanescens ΠΏΠΎΠ΄Π°Π²Π»ΡΠ΅Ρ Π£Π€-ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΠΠ -1, ΠΌΠ ΠΠ ΠΈ ΠΠΠ Π Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°.
7. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π²ΡΡΠΎΠΊΠΎΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ a-L-ΡΡΠΊΠ°Π½ ΠΈΠ· S. cichorioides ΡΡΠΈΠ»ΠΈΠ²Π°Π΅Ρ Π°Π½ΡΠΈΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΠ΅ΡΠ²Π΅ΡΠ°ΡΡΠΎΠ»Π° ΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ· ΡΠ°ΠΊΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΡΠ΅ΡΠ²Π΅ΡΠ°ΡΡΠΎΠ»ΠΎΠΌ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΉ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΡΠ²ΡΠ·Π°Π½ Ρ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠ΅ΠΉ ΠΈΠ½ΠΈΡΠΈΠ°ΡΠΎΡΠ½ΡΡ ΠΈ ΡΡΡΠ΅ΠΊΡΠΎΡΠ½ΡΡ ΠΊΠ°ΡΠΏΠ°Π· ΠΏΡΠΈ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ ΡΠ΅ΡΠ²Π΅ΡΠ°ΡΡΠΎΠ»Π° ΠΈ ΡΡΠΊΠΎΠΈΠ΄Π°Π½Π°.
8. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΡΡΡΡΠΊΡΡΡΠ½ΡΡ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΡΡΠΊΠΎΠΈΠ΄Π°Π½ΠΎΠ² ΠΈ ΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ 1—>3-ΡΠ²ΡΠ·Π°Π½Π½ΡΡ ΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΎΡΡΠ°ΡΠΊΠΎΠ² Π°-Π¬-ΡΡΠΊΠΎΠ·Ρ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎ Π΄Π»Ρ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΠΠ-ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΡΠΎΡΡΠ° ΠΊΠΎΠ»ΠΎΠ½ΠΈΠΉ ΡΠ°ΠΊΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°ΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΈ ΡΠ°ΡΡΠΈΡΠ½ΠΎ Π°ΡΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄, ΡΠΎΡΡΠΎΡΡΠΈΠΉ ΠΈΠ· 1—>3- ΠΈ 1—>4-ΡΠ²ΡΠ·Π°Π½Π½ΡΡ ΠΎΡΡΠ°ΡΠΊΠΎΠ² Π°-Π¬-ΡΡΠΊΠΎΠ·Ρ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΠ΅Ρ ΠΏΡΠΎΡΠ΅ΡΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΠΎΡΡΠ° ΠΊΠΎΠ»ΠΎΠ½ΠΈΠΉ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°Π΄Π»Ρ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΡΠΎΡΡΠ° ΠΊΠΎΠ»ΠΎΠ½ΠΈΠΉ ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎ ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠ΅ Π² ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π΅ ΡΡΠΊΠΎΠΈΠ΄Π°Π½Π° Π±ΠΎΠ»ΡΡΠΎΠ³ΠΎ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° ΠΎΡΡΠ°ΡΠΊΠΎΠ² ΡΡΠ»ΡΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΈ ΡΠ°ΡΡΠΈΡΠ½ΠΎ Π°ΡΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π³Π°Π»Π°ΠΊΡΠΎΠ·Ρ ΠΈ ΡΡΠΊΠΎΠ·Ρ, ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½Π½ΡΡ 1—>3- ΠΈ/ΠΈΠ»ΠΈ 1—>4−0-Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ΄Π½ΡΠΌΠΈ ΡΠ²ΡΠ·ΡΠΌΠΈ.
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