ΠΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠ° ΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² ΠΊΡΠ»ΡΡΡΡΠ΅ ΡΠΊΠ°Π½ΠΈ ΠΈ ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΉ ΠΌΠΎΠ·Π³ ΠΊΡΡΡ
ΠΠ°ΡΡΠΎΡΡΠ΅Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅, ΠΊΠΎΡΠΎΡΠΎΠ΅ Π±ΡΠ»ΠΎ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΎ Π½Π° ΡΠΎ, ΡΡΠΎΠ±Ρ Π² ΡΠ°ΠΌΠΊΠ°Ρ ΠΎΠ΄Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΠΏΡΠΎΠ²Π΅ΡΡΠΈ Π°Π½Π°Π»ΠΈΠ· ΡΠ°Π·Π²ΠΈΡΠΈΡ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² ΠΊΡΠ»ΡΡΡΡΠ΅ ΡΠΊΠ°Π½ΠΈ ΠΈ ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² ΠΌΠΎΠ·Π³ Π²Π·ΡΠΎΡΠ»ΡΡ ΠΊΡΡΡ, ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠΈ Π²ΡΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΡ ΡΡΡΠΏΠ΅Π½Π·ΠΈΠΉ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΠΈΠ· ΡΠΊΠ°Π½Π΅ΠΉ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° 912-ΡΠΈ Π½Π΅Π΄Π΅Π»Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ, Π² Π±Π΅ΡΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΡΡ … Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΏΠΈΡΠΎΠΊ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΉ
- ΠΠ»Π°Π²Π° 1. ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- 1. 1. ΠΠ΅ΠΉΡΠΎΠ³Π΅Π½Π΅Π· ΠΈ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ Π²Π·ΡΠΎΡΠ»ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ
- 1. 2. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅, ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ in vitro
- 1. 3. ΠΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠ½ΠΎΠ²Ρ Π½Π΅ΠΉΡΠΎΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ
- 1. 4. Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π² Π¦ΠΠ‘
- ΠΠ»Π°Π²Π° 2. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ
- 2. 1. ΠΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ /ΠΏΡΠΎΠ³Π΅Π½ΠΈΡΠΎΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
- 2. 2. ΠΠ΅ΡΠΎΠ΄Ρ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΊΡΠ»ΡΡΡΡ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ /ΠΏΡΠΎΠ³Π΅Π½ΠΈΡΠΎΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΉ ΠΌΠΎΠ·Π³ Π²Π·ΡΠΎΡΠ»ΡΡ ΠΊΡΡΡ
- 2. 3. Π€ΠΈΠΊΡΠ°ΡΠΈΡ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°
- 2. 4. ΠΠ΅ΡΠΎΠ΄Ρ ΡΠΈΠΊΡΠ°ΡΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΊΡΠ»ΡΡΡΡ
- 2. 5. ΠΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΠ΅Π·ΠΎΠ² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΊΡΡΡ
- 2. 6. ΠΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΠ΅Π·ΠΎΠ² Π½Π΅ΠΉΡΠΎΡΡΠ΅Ρ
- 2. 7. ΠΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ
- 2. 8. ΠΠ΅ΡΠΎΠ΄Ρ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠΊΡΠ°ΡΠΈΠ²Π°Π½ΠΈΡ
- 2. 9. ΠΠ½ΡΠΈΡΠ΅Π»Π° ΠΈ ΠΈΡ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠ΅
- 2. 10. ΠΠΎΠΊΡΠΌΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ
- 2. 11. ΠΠΈΠΏΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΌΠΎΠ΄Π΅Π»Ρ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°
- ΠΠ»Π°Π²Π° 3. ΠΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠ° ΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ
ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² ΠΊΡΠ»ΡΡΡΡΠ΅ in vitro
- 3. 1. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅
- 3. 2. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 3. 3. ΠΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅
- ΠΠ»Π°Π²Π° 4. Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ
ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ
/ΠΏΡΠΎΠ³Π΅Π½ΠΈΡΠΎΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΉ ΠΌΠΎΠ·Π³ Π²Π·ΡΠΎΡΠ»ΡΡ
ΠΊΡΡΡ
- 4. 1. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅
- 4. 2. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 4. 3. ΠΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅
- ΠΠ»Π°Π²Π° 5. Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π½Π΅Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΉ ΠΌΠΎΠ·Π³ Π²Π·ΡΠΎΡΠ»ΡΡ
ΠΊΡΡΡ
- 5. 1. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅
- 5. 2. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ
- 5. 3. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 5. 4. ΠΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅
ΠΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠ° ΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² ΠΊΡΠ»ΡΡΡΡΠ΅ ΡΠΊΠ°Π½ΠΈ ΠΈ ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΉ ΠΌΠΎΠ·Π³ ΠΊΡΡΡ (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ. Π ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π΅ Π²ΡΠ΅ΠΌΡ Π² ΠΈΠ΅ΠΉΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΎΡΠΎΠ±ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΏΡΠΈΠΊΠΎΠ²Π°Π½ΠΎ ΠΊ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠ΅. ΠΠ° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ ΠΎΠΊΠΎΠ½ΡΠ°ΡΠ΅Π»ΡΠ½ΠΎ ΡΡΠ²Π΅ΡΠ΄ΠΈΠ»ΠΈΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΎ ΠΏΠΎΡΡΠΎΡΠ½Π½ΠΎΠΌ Π½Π΅ΠΉΡΠΎΠ³Π΅ΠΏΠ΅Π·Π΅ Π² Π½Π΅ΠΊΠΎΡΠΎΡΡΡ ΠΎΠ±Π»Π°ΡΡΡΡ ΠΌΠΎΠ·Π³Π° ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ , ΠΊΠΎΡΠΎΡΡΠΉ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅ΡΡΡ Π·Π° ΡΡΠ΅Ρ ΠΏΡΠ»Π° ΠΏΠ΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ (Doetsch et al., 1999; Palmer et al., 2000; Seri et al., 2001). ΠΠ΅ΠΉΡΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡ ΠΊΠ°ΠΊ ΠΊΠ»Π΅ΡΠΊΠΈ Ρ Π½Π΅ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½Π½ΡΠΌ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ, ΡΠΏΠΎΡΠΎΠ±Π½ΡΠ΅ ΠΊ ΡΠ°ΠΌΠΎΠ²ΠΎΡΠΏΡΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΈ Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ ΠΌΡΠ»ΡΡΠΈΠΏΠΎΡΠ΅Π½ΡΠ½ΡΡ ΠΏΠΎΡΠΎΠΌΠΊΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ Π² ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠΈ Π΄Π°Π΄ΡΡ ΡΡΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ Π²Π΅ΡΠ²ΠΈ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ: Π½Π΅ΠΉΡΠΎΠ½Ρ, Π°ΡΡΡΠΎΡΠΈΡΡ ΠΈ ΠΎΠ»ΠΈΠ³ΠΎΠ΄Π΅Π½Π΄ΡΠΎΡΠΈΡΡ.
Π‘ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌ ΡΠ°Π³ΠΎΠΌ Π² ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΡΠ°Π»ΠΎ ΠΈΡ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅. Π ΠΊΡΠ»ΡΡΡΡΠ΅ in vitro ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎ ΡΠ°Π·ΠΌΠ½ΠΎΠΆΠ°ΡΡΡΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ Π±Π΅ΡΡΡΠ²ΠΎΡΠΎΡΠΎΡΠΏΡΡ ΡΡΠ΅Π΄ Ρ ΡΠΎΡΡΠΎΠ²ΡΠΌΠΈ ΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ, ΡΠΎΡΠΌΠΈΡΡΡ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΠΏΠ»Π°Π²Π°ΡΡΠΈΠ΅ ΠΊΠΎΠ»ΠΎΠ½ΠΈΠΈ ΡΠ°ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎΠΉ ΡΠΎΡΠΌΡ, ΠΊΠΎΡΠΎΡΡΠ΅ Π½Π°Π·ΡΠ²Π°ΡΡΡΡ Π½Π΅ΠΉΡΠΎΡΡΠ΅ΡΠ°ΠΌΠΈ (Reynolds and Weiss, 1992; Lois and Alvarez-Buylla, 1993; Palmer et al., 1995; Weiss et al., 1996). ΠΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠΎΡΡΠ΅Ρ Π΄Π°Π»ΠΎ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½Ρ Π΄Π»Ρ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΡΠ²ΠΎΠΉΡΡΠ²Π° «ΡΡΠ²ΠΎΠ»ΠΎΠ²ΠΎΡΡΠΈ» Ρ ΡΠ΅Ρ ΠΈΠ»ΠΈ ΠΈΠ½ΡΡ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΡ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΠΌΠ΅Π½Π½ΠΎ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΡΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ ΠΎΠ΄Π° Π±ΡΠ»ΠΎ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ, ΡΡΠΎ Π½Π΅ΠΊΠΎΡΠΎΡΡΠ΅ ΠΎΠ±Π»Π°ΡΡΠΈ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠ΅Π³ΠΎΡΡ ΠΈ Π·ΡΠ΅Π»ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ , Π²ΠΊΠ»ΡΡΠ°Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΡΠΎΠ΄Π΅ΡΠΆΠ°Ρ ΠΏΡΠ»Ρ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ (Reynolds and Weiss, 1996; Carpenter et al., 1999; Kukekov et al., 1999; Pagano et al., 2000; Vescovi et al., 1999).
Π‘ ΠΎΠ΄Π½ΠΎΠΉ ΡΡΠΎΡΠΎΠ½Ρ, ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΠΎ-Π½ΠΎΠ²ΠΎΠΌΡ ΠΏΠΎΠ΄ΠΎΠΉΡΠΈ ΠΊ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, Π° Ρ Π΄ΡΡΠ³ΠΎΠΉ — ΡΠ°Π·Π²ΠΈΡΡ ΠΈΠ΄Π΅Ρ ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΉ ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ.
ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ ΠΌΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ ΠΊΡΠ»ΡΡΡΡΡ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½Ρ (Mokry et al., 1996; Carpenter et al., 1999; Kukekov et al., 1999; Vescovi et al., 1999; Suslov et al., 2002; Bez et al., 2003; Lobo et al., 2003), ΠΈ ΡΡΠ° Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΡ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π° ΠΌΠ½ΠΎΠ³ΠΈΠΌΠΈ ΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ. ΠΠΎ ΡΡΠΎΠΉ ΠΏΡΠΈΡΠΈΠ½Π΅ ΡΠ°ΠΊΠΈΠ΅ ΠΊΡΠ»ΡΡΡΡΡ ΡΡΠ°Π»ΠΈ Π½Π°Π·ΡΠ²Π°ΡΡ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΡΠΌΠΈ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ /ΠΏΡΠΎΠ³Π΅Π½ΠΈΡΠΎΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ (ΠΠ‘ΠΠ). ΠΠ΄Π΅ΡΡ Π²ΠΎΠ·Π½ΠΈΠΊΠ°Π΅Ρ Π²ΠΎΠΏΡΠΎΡ ΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΡ Π²ΡΡΠ°ΡΠΈΠ²Π°Π½ΠΈΡ ΠΈ ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΈΡ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ. ΠΡΠΎΡ Π²ΠΎΠΏΡΠΎΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΈΠ°Π»ΡΠ½ΡΠΌ ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ ΠΊΡΠ»ΡΡΡΡΠ°ΠΌ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π°Π½Π°Π»ΠΈΠ· ΠΊΡΠ»ΡΡΡΡ in vitro ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΡΠΌ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΈΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ Π΄Π»Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ, ΠΈ ΠΏΠΎΡΡΠΎΠΌΡ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎ ΡΡΠΈΡΡΠ²Π°ΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΌΠΎΠ·Π³Π° Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ .
ΠΠ΅ΠΉΡΠΎΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ ΡΠΆΠ΅ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ Π΄Π°Π²Π½ΠΎ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΠΊΠ°ΠΊ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ Π΄Π»Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ ΠΌΠΎΠ·Π³Π°. Π 70-Ρ ΠΈ 80-Ρ Π³ΠΎΠ΄Π°Ρ ΠΏΡΠΎΡΠ»ΠΎΠ³ΠΎ ΡΡΠΎΠ»Π΅ΡΠΈΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ Ρ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠ΅ΠΉ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ Π±ΠΎΠ»ΡΡΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ ΠΎΠ΄Π° ΠΊΠ°ΠΊ Π² ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ Π²ΠΎΠΏΡΠΎΡΠ°Ρ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ, ΡΠ°ΠΊ ΠΈ Π΄Π»Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ΅Π»Π΅ΠΉ. ΠΠ° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ ΠΈΠΌΠ΅Π½Π½ΠΎ ΠΏΠ΅ΡΠ΅ΡΠ°Π΄ΠΊΠ° ΠΊΡΠ»ΡΡΡΡ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΡΠ°Π»Π° Π½ΠΎΠ²ΡΠΌ ΡΡΠ°ΠΏΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ, ΡΠ²ΡΠ·Π°Π½Π½ΠΎΠ³ΠΎ Ρ Π½Π΅ΠΉΡΠΎΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠ΅ΠΉ (Svendsen et al., 1996; Lundberg et al., 1997; Snyder et al., 1997; Brock et al., 1998; Fricker et al., 1999; Vescovi et al., 1999; Auerbach et al., 2000; Rubio et al., 2000; Akiyama et al., 2001; Ogawa et al., 2002; Enomoto et al., 2003). ΠΠ½Π°Π»ΠΈΠ· ΠΏΠ΅ΡΠ΅ΠΆΠΈΠ²Π°Π½ΠΈΡ ΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΡ Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΡ Π½Π° ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ ΠΌΠΎΠ΄Π΅Π»ΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΌΠΎΠ·Π³Π° Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎ Π½Π΅ΠΉΡΠΎΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ.
ΠΠ΄Π½Π°ΠΊΠΎ Π΄Π»Ρ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΠΌΠΎΠ³ΠΎ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΊΡΠ»ΡΡΡΡ ΡΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ Π½Π΅ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΡΠ»ΡΡΡΡ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π΄Π»Ρ Π°ΡΡΠΎΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π½Π΅Π²ΡΠΏΠΎΠ»Π½ΠΈΠΌΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ, Π² ΡΠ²ΡΠ·ΠΈ Ρ ΡΠ΅ΠΌ, ΡΡΠΎ Π½Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ Π΄ΠΎΡΡΡΠΏΠ° ΠΊ ΠΎΠ±Π»Π°ΡΡΡΠΌ Π·ΡΠ΅Π»ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ ΡΠ°ΠΊΠΈΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ Π²ΡΠ΄Π΅Π»Π΅Π½Ρ. ΠΡΡΠ³Π°Ρ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ° Π½ΠΎΡΠΈΡ ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Ρ Π°ΡΠ°ΠΊΡΠ΅Ρ. ΠΡΠΎ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈΠ· ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² ΡΠΊΠ°Π½Π΅ΠΉ ΠΌΠΎΠ·Π³Π° ΡΠΌΠ±ΡΠΈΠΎΠ½ΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΠΏΡΡΠ΅ΠΌ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠ³ΠΎ Π°Π±ΠΎΡΡΠ°. ΠΠΎ ΡΡΠΎΠΉ ΠΏΡΠΈΡΠΈΠ½Π΅ Π²ΠΎΠ·Π½ΠΈΠΊΠ»Π° Π·Π°Π΄Π°ΡΠ° ΠΏΠΎΠΈΡΠΊΠ° Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²Π½ΡΡ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ² Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ. Π‘ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΠΎ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΊΠ°Ρ , ΠΏΡΠΈΡΡΡΡΡΠ²ΡΡΡΠΈΡ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π²ΠΎ Π²ΡΠ΅Ρ ΠΎΡΠ³Π°Π½Π°Ρ ΠΈ ΡΠΊΠ°Π½ΡΡ , ΠΏΠΎΡΠ²ΠΈΠ»Π°ΡΡ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΡ «ΠΏΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ», ΠΊΠΎΡΠΎΡΠ°Ρ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² ΡΠΎΠΌ, ΡΡΠΎ ΠΏΡΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²Π°Ρ ΠΊΠ»Π΅ΡΠΊΠ° Π΄Π°Π½Π½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΡΠΏΠΎΡΠΎΠ±Π½Π° Π΄Π°Π²Π°ΡΡ ΠΏΠΎΡΠΎΠΌΠΊΠΎΠ² Ρ Π½Π΅ΡΠΈΠΏΠΈΡΠ½ΡΠΌΠΈ Π²Π΅ΡΠ²ΡΠΌΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ. Π ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, ΠΈΠΌΠ΅ΡΡΡΡ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ ΠΌΠ΅Π·Π΅ΠΈΡ ΠΈΠΌΠ½ΡΠ΅ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ (ΠΠ‘Π) ΡΡΡΠΎΠΌΡ ΠΊΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΌΠΎΠ³ΡΡ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΡΡ ΠΏΠΎ ΠΏΠ΅ΠΉΡΠ°Π»ΡΠ½ΠΎΠΌΡ ΠΏΡΡΠΈ ΠΊΠ°ΠΊ in vitro, ΡΠ°ΠΊ ΠΈ ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΡΡ Π½Π΅ΡΠ²Π½ΡΡ ΡΠΈΡΡΠ΅ΠΌΡ (Azizi et al., 1998; Kopen et al., 1999; Nakano et al., 2001; Priller et al., 2001; Munoz-Elias et al., 2004). ΠΡΠΈ Π΄Π°Π½Π½ΡΠ΅ Π² ΠΊΠΎΡΠ½Π΅ ΠΌΠ΅Π½ΡΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ΅. ΠΠ΄Π½Π°ΠΊΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠ½ΠΎΠ³ΠΈΡ ΡΠ°ΠΊΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π²ΡΠ΅-ΡΠ°ΠΊΠΈ ΠΌΠΎΠΆΠ½ΠΎ ΠΏΠΎΡΡΠ°Π²ΠΈΡΡ ΠΏΠΎΠ΄ ΡΠΎΠΌΠ½Π΅Π½ΠΈΠ΅.
ΠΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Π½ΡΠ΅ ΡΠ°Π±ΠΎΡΡ ΠΏΠΎ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠΈΡΡΡΡ ΡΠ²ΠΎΠΉ Π²Π·Π³Π»ΡΠ΄ Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΌ Π»ΠΈΠ±ΠΎ Π½Π° Π°Π½Π°Π»ΠΈΠ·Π΅ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΊΡΠ»ΡΡΡΡ, Π»ΠΈΠ±ΠΎ Π½Π° ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ. ΠΠΎ ΡΡΠΎΠΉ ΠΏΡΠΈΡΠΈΠ½Π΅ Π²ΠΎΠ·Π½ΠΈΠΊΠ°Π΅Ρ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ Π² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΠΊΠΎΡΠΎΡΠΎΠ΅ Π·Π°Ρ Π²Π°ΡΠΈΠ»ΠΎ Π±Ρ ΠΎΠ±Π° Π°ΡΠΏΠ΅ΠΊΡΠ° ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΠΏΠΎΡΠ²ΠΈΠ²ΡΠΈΠ΅ΡΡ Π² ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΠ°Π±ΠΎΡΡ, Π² ΠΊΠΎΡΠΎΡΡΡ Π°Π²ΡΠΎΡΡ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΡΡ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ Π΄ΠΈΡΡΠ΅ΡΠ΅ΠΏΡΠΈΡΠΎΠ²ΠΊΡ ΠΊΡΠ»ΡΡΡΡ ΠΌΠ΅Π·Π΅Π½Ρ ΠΈΠΌΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² ΠΌΠΎΠ·Π³, ΡΡΠ΅Π±ΡΡΡ ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ²Π΅ΡΠΊΠΈ. ΠΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΡΡΠΎΠ³ΠΎ, ΠΈΠΌΠ΅Π½Π½ΠΎ ΠΏΠ°ΡΠ°Π»Π»Π΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΊΡΠ»ΡΡΡΡ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΠΈ ΠΌΠ΅Π·Π΅Π½Ρ ΠΈΠΌΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ in vitro ΠΈ ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ ΠΏΡΠΎΡΡΠ½ΠΈΡΡ ΡΠΈΡΡΠ°ΡΠΈΡ Π² Π΄Π°Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅.
Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. Π¦Π΅Π»Ρ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΎΠΈΠΏΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΡΠΎΡΡΠΎΡΠ»Π° Π² ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅ΠΈΡΠΈΡΠΎΠ²ΠΊΠΈ ΠΈ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠΈ Π² ΠΊΡΠ»ΡΡΡΡΠ°Ρ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ /ΠΏΡΠΎΠ³Π΅Π½ΠΈΡΠΎΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠ΅Π³ΠΎΡΡ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° in vitro ΠΈ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² ΠΌΠΎΠ·Π³ ΠΊΡΡΡ.
ΠΠ°Π΄Π°ΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ.
1. Π‘ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΡ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°ΡΡ ΠΊΡΠ»ΡΡΡΡΡ ΠΠ‘ΠΠ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠ΅Π³ΠΎΡΡ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°.
2. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΡΡΠ΄ΡΠ±Ρ (Π΄ΠΈΡΡΠ΅ΡΠ΅ΠΏΡΠΈΡΠΎΠ²ΠΊΡ, ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΡ ΠΈ ΠΌΠΈΠ³ΡΠ°ΡΠΈΡ) ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈΠ· ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Ρ ΡΠΊΠ°Π½ΡΠΌΠΈ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ².
3. ΠΠ·ΡΡΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ² ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π½Π° ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΊΡΡΡ, ΠΏΠΎΠ΄Π²Π΅ΡΠ³Π½ΡΡΡΡ ΠΎΡΡΡΠΎΠΉ Π³ΠΈΠΏΠΎΠΊΡΠΈΠΈ, ΠΈ ΠΏΠ° Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΡΡ ΠΊΠ°ΡΡΠΈΠ½Ρ Π½Π΅ΠΉΡΠΎΠ΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ².
4. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΊΡΠ»ΡΡΡΡΡ ΠΠ‘Π ΡΡΡΠΎΠΌΡ ΠΊΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΏΠ΅ΡΠ΅ΠΆΠΈΠ²Π°Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΡΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΉ ΠΌΠΎΠ·Π³ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ ΠΊΡΡΡ ΠΈ ΠΊΡΡΡ Ρ ΠΎΡΡΡΠΎΠΉ Π³ΠΈΠΏΠΎΠΊΡΠΈΠ΅ΠΉ.
ΠΠ°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π°. ΠΠ°ΡΡΠΎΡΡΠ°Ρ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° Π°Π½Π°Π»ΠΈΠ·Ρ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° ΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π² Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΠΊΡΠ»ΡΡΡΡΠ°Ρ , ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΠΈΠ· ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠ΅Π³ΠΎΡΡ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΈΡ ΡΡΠ΄ΡΠ±Ρ ΠΈ Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΡ Π² ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΌΠΎΠ·Π³Π΅ ΠΊΡΡΡ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π² ΡΠ°Π±ΠΎΡΠ΅ Π±ΡΠ» ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ Π²ΠΎΠΏΡΠΎΡ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ Π½Π°ΡΠΈΠ²Π½ΡΡ ΠΊΡΠ»ΡΡΡΡ ΠΌΠ΅Π·Π΅Π½Ρ ΠΈΠΌΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΠΌΠΈΠΊΡΠΎΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΠΈ Π·ΡΠ΅Π»ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΊΡΡΡ ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ.
ΠΠΏΠ΅ΡΠ²ΡΠ΅ Π² ΡΠ°ΠΌΠΊΠ°Ρ ΠΎΠ΄Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎ Π±ΡΠ»ΠΈ ΠΎΡ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½Ρ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΠΈΠΌΠΌΡΠΏΠΎΠ³ΠΈΡΡΠΎΡ ΠΈΠΌΠΈΠΈ ΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ ΠΊΡΠ»ΡΡΡΡΡ ΠΠ‘ΠΠ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΈ Π·Π°ΡΠ΅ΠΌ Π±ΡΠ»Π° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΠΊΡΠ»ΡΡΡΡΡ ΠΠ‘ΠΠ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΈ Π·Π°ΡΠ΅ΠΌ Π±ΡΠ»Π° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΡΡΠ΄ΡΠ±Π° ΡΡΠΈΡ ΠΎΡ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΡΡ ΠΊΡΠ»ΡΡΡΡ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² ΠΌΠΎΠ·Π³ ΠΊΡΡΡ. ΠΠ½Π°Π»ΠΈΠ· ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΊΡΠ»ΡΡΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ ΠΎΠ½ΠΈ Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½Ρ. ΠΠ΅ΠΉΡΠΎΡΡΠ΅ΡΡ Π²ΠΊΠ»ΡΡΠ°ΡΡ ΠΊΠ»Π΅ΡΠΊΠΈ, Π½Π°Ρ ΠΎΠ΄ΡΡΠΈΠ΅ΡΡ Π½Π° ΡΠ°Π·Π½ΡΡ ΡΡΠ°ΠΏΠ°Ρ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ. Π ΠΎΡΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅ΡΡΡ Π·Π° ΡΡΠ΅Ρ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ , ΠΏΡΠΎΠ³Π΅Π½ΠΈΡΠΎΡΠ½ΡΡ ΠΈ Π³Π»ΠΈΠ°Π»ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π°Π΄Π³Π΅Π·ΠΈΠ²Π½ΡΡ Π½Π΅ΠΉΡΠΎΡΡΠ΅Ρ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, ΡΡΠΎ ΠΌΠ½ΠΎΠ³ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΌΠΎΠ³ΡΡ ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΠΎΠ²Π°ΡΡ ΠΌΠ°ΡΠΊΠ΅ΡΡ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠΎΠ² ΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠΎΡΡΠ΅Ρ Π½Π° Π±Π΅ΡΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΡΡΠ΅Π΄Π΅ Ρ ΠΌΠΈΡΠΎΠ³Π΅Π½Π°ΠΌΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΠΎΠ»ΡΡΠΈΡΡ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠΎΠ»ΡΠΊΠΎ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ΄Π°. ΠΠΏΠ΅ΡΠ²ΡΠ΅ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ Π΄ΠΈΡΡΡΠ·Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΌΠΎΠ·Π³Π° Ρ ΠΊΡΡΡ Π±ΡΠ»ΠΎ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ, ΡΡΠΎ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΊΡΠ»ΡΡΡΡ ΠΏΡΠΎΠΈΡΡ ΠΎΠ΄ΠΈΡ Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΈ ΡΠ»ΡΡΡΠ°Π΅ΡΡΡ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΡ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ² ΠΌΠΎΠ·Π³Π° ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠ°. ΠΡΠΎ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΡΠΎ, ΡΡΠΎ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΡ ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ ΠΈΠ·ΠΌΠ΅Π½ΡΡΡ ΡΡΠ΅Π΄Ρ ΠΌΠΈΠΊΡΠΎΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°, ΠΏΡΠ΅Π΄ΠΎΡΠ²ΡΠ°ΡΠ°Ρ Π³ΠΈΠ±Π΅Π»Ρ Π·Π°ΡΡΠΎΠ½ΡΡΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ΠΌ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ². ΠΠ½Π°Π»ΠΈΠ· ΠΏΠ΅ΡΠ΅ΠΆΠΈΠ²Π°Π½ΠΈΡ ΡΠ°ΠΌΠΈΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ² ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ ΠΊΠ»Π΅ΡΠΊΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΡΠΎΡ ΡΠ°Π½ΡΡΡΡΡ ΠΊΠ°ΠΊ ΠΌΠΈΠ½ΠΈΠΌΡΠΌ 27 Π΄Π½Π΅ΠΉ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ Π±Π΅Π· ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΠΈ. Π ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠ°Ρ Π²ΡΡΠ²Π»ΡΡΡΡΡ ΠΊΠ»Π΅ΡΠΊΠΈ Π½Π° ΡΠ°Π·Π½ΡΡ ΡΡΠ°ΠΏΠ°Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ: ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΠ΅ ΠΈ ΠΏΡΠΎΠ³Π΅Π½ΠΈΡΠΎΡΠ½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ, Π½Π΅ΠΉΡΠΎΠ±Π»Π°ΡΡΡ ΠΈ Π³Π»ΠΈΠΎΠ±Π»Π°ΡΡΡ. ΠΠ΄Π½Π°ΠΊΠΎ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ² Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π½Π΅ Π±ΡΠ»ΠΎ. Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΌΠΈΠ³ΡΠΈΡΡΡΡ ΠΏΠΎ ΡΠΊΠ°Π½ΡΠΌ ΠΌΠΎΠ·Π³Π° ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠ°, ΡΠ°ΡΡΠΎ Π²Π΄ΠΎΠ»Ρ ΠΊΠ°ΠΏΠΈΠ»Π»ΡΡΠΎΠ².
ΠΡΠΏΠΎΠ»ΡΠ·ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠ΄Ρ ΠΎΠ΄Ρ, Π°Π½Π°Π»ΠΎΠ³ΠΈΡΠ½ΡΠ΅ ΡΠ΅ΠΌ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ»ΠΈ Π΄Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ, Π±ΡΠ» ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΊΡΠ»ΡΡΡΡΡ ΠΠ‘Π ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° in vitro ΠΈ ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ. ΠΠ΄Π΅ΡΡ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ Π±ΡΠ»ΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΡΠ±Π΅Π΄ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ Π½Π°ΡΠΈΠ²Π½ΡΠ΅ ΠΠ‘Π Π½Π΅ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΡΡΡΡΡ Π² Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΠΎΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ Π² ΡΡΠ΅Π΄Π΅ ΠΌΠΈΠΊΡΠΎΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΡ Π·ΡΠ΅Π»ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°. Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΡ ΠΎΡΡΠΎΡΠ³Π°ΡΡΡΡ Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ ΠΏΠΎΠ»Π½ΠΎΠΉ ΡΠ»ΠΈΠΌΠΈΠ½Π°ΡΠΈΠ΅ΠΉ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΊ 20-ΡΠΌ ΡΡΡΠΊΠ°ΠΌ. ΠΠΎΠΊΡΡΠ³ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ² ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΡΡΡ ΠΌΠΎΡΠ½Π°Ρ Π³Π»ΠΈΠ°Π»ΡΠ½Π°Ρ ΡΠ΅Π°ΠΊΡΠΈΡ, ΠΈ Π½Π°Π±Π»ΡΠ΄Π°ΡΡΡΡ ΡΠΈΠ»ΡΠ½ΡΠ΅ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΠΊΠ°Π½ΠΈ. Π ΡΠΎΠΆΠ΅ Π²ΡΠ΅ΠΌΡ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΡΠ΅ΠΌΡΠΉ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ ΡΠΈΠ±ΡΠΎΠ½Π΅ΠΊΡΠΈΠ½, ΠΏΠΎ-Π²ΠΈΠ΄ΠΈΠΌΠΎΠΌΡ, ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅Ρ Π²ΡΠ°ΡΡΠ°Π½ΠΈΠ΅ Π½Π΅ΡΠ²Π½ΡΡ Π²ΠΎΠ»ΠΎΠΊΠΎΠ½ Ρ ΠΎΠ·ΡΠΈΠ½Π° Π² ΠΎΠ±Π»Π°ΡΡΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠ°.
Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ»ΡΠΆΠ°Ρ Π²Π°ΠΆΠ½ΡΠΌ Π·Π²Π΅Π½ΠΎΠΌ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΠΌΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ (ΡΠ°ΠΊΠΈΠΌΠΈ ΠΊΠ°ΠΊ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠ°, ΡΠΎΠ»Ρ ΠΌΠΈΠΊΡΠΎΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ Π² Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠ΅, ΠΏΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ) ΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠ΅ΠΉ ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ.
ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΡΠ°Π±ΠΎΡΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π² Π½Π°ΡΡΠΎΡΡΠ΅ΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ, ΡΠ»ΡΠΆΠ°Ρ Π±Π°Π·ΠΎΠΉ Π΄Π»Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ΠΎΠ² ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΠΎ, ΡΡΠΎ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΡ ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Π½Π΅ΠΉΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π½Π° Π΄Π΅Π³Π΅Π½Π΅ΡΠΈΡΡΡΡΠΈΠ΅ Π½Π΅ΠΉΡΠΎΠ½Ρ ΠΏΡΠΈ Π΄ΠΈΡΡΡΠ·Π½ΠΎΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠΈ ΠΌΠΎΠ·Π³Π°, ΠΈ ΡΡΠΎ Π½Π΅ΠΉΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅, ΠΏΠΎΠΆΠ°Π»ΡΠΉ, Π΄ΠΎΠ»ΠΆΠ½ΠΎ ΡΠ»ΡΠΆΠΈΡΡ ΠΎΡΠΏΡΠ°Π²Π½ΠΎΠΉ ΡΠΎΡΠΊΠΎΠΉ ΠΏΡΠΈ ΡΠΎΡΠΌΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ΅Π»Π΅ΠΉ ΠΈ Π·Π°Π΄Π°Ρ Π΄Π»Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π½Π΅ΠΉΡΠΎΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ. ΠΠ΄Π΅ΡΡ ΡΠ²Π½ΠΎ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Π° Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΠΈΠ· ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ², ΠΊΠΎΡΠΎΡΡΠΉ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ Π΄Π»Ρ Π½Π΅ΠΉΡΠΎΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ΅Π»ΡΡ , ΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π΅Π΄ΠΈΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΈ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΈ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠΈ ΡΠ΅Ρ ΠΈΠ»ΠΈ ΠΈΠ½ΡΡ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ ΠΊΠ»Π΅ΡΠΎΠΊ.
ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π² ΠΊΡΡΡΠ°Ρ Π»Π΅ΠΊΡΠΈΠΉ Π² Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ ΠΠ£ΠΠ°Ρ .
ΠΡΠ²ΠΎΠ΄Ρ.
1. Π Π½Π΅ΠΉΡΠΎΡΡΠ΅ΡΠ°Ρ ΠΏΡΠΎΠΈΡΡ ΠΎΠ΄ΠΈΡ ΡΠΏΠΎΠ½ΡΠ°Π½Π½Π°Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠ° ΠΊΠ»Π΅ΡΠΎΠΊ.
2. ΠΠ΅ΠΉΡΠΎΡΡΠ΅ΡΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Ρ ΠΊΠ»Π΅ΡΠΊΠΈ ΡΠΎΠ»ΡΠΊΠΎ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ΄Π°, ΡΠ°ΡΡΡ ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ ΡΠΏΠΎΡΠΎΠ±Π½Π° ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°ΡΡ ΡΠΎΠ·Π΅ΡΠΊΠΎ-ΠΏΠΎΠ΄ΠΎΠ±Π½ΡΠ΅ ΡΡΡΡΠΊΡΡΡΡ.
3. Π ΠΎΡΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ Π² ΠΊΡΠ»ΡΡΡΡΠ΅ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅ΡΡΡ Π·Π° ΡΡΠ΅Ρ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ , ΠΏΡΠΎΠ³Π΅ΠΈΠΈΡΠΎΡΠ½ΡΡ ΠΈ Π³Π»ΠΈΠ°Π»ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ.
4. ΠΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² ΠΌΠΎΠ·Π³ ΠΊΡΡΡ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΡΠΏΠΎΡΠΎΠ±Π½Ρ ΠΏΠ΅ΡΠ΅ΠΆΠΈΠ²Π°ΡΡ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ ΠΌΠ΅ΡΡΡΠ° Π±Π΅Π· ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΠΈ.
5. ΠΠ΅ΡΠ΅ΠΆΠΈΠ²Π°Π½ΠΈΠ΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ² Π² Π±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΡΡΠ»ΠΎΠ²ΠΈΠΉ ΠΏΡΠ΅Π΄Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΡΠ΅ΠΌ ΠΎΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΠΌΠΈΠΊΡΠΎΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΡ ΠΌΠΎΠ·Π³Π° ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠ°.
6. Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΡ ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΏΠΎΠ²ΡΡΠ°ΡΡ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΡ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ² ΠΌΠΎΠ·Π³Π° ΠΊΡΡΡ, ΠΏΠ΅ΡΠ΅Π½Π΅ΡΡΠΈΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΎΡΡΡΠΎΠΉ Π³ΠΈΠΏΠΎΠΊΡΠΈΠΈ, ΡΡΠΎ Π½Π°Ρ ΠΎΠ΄ΠΈΡ ΠΎΡΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ Π² Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ .
7. Π€Π°ΠΊΡΠΎΡΡ ΠΌΠΈΠΊΡΠΎΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΡ ΠΌΠΎΠ·Π³Π° Π½Π΅ ΡΡΠΈΠΌΡΠ»ΠΈΡΡΡΡ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΊΡΠ»ΡΡΡΡΡ ΠΠ‘Π.
ΠΠ²ΡΠΎΡ Π²ΡΡΠ°ΠΆΠ°Π΅Ρ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ½ΠΎΡΡΡ ΡΠ²ΠΎΠΈΠΌ ΠΊΠΎΠ»Π»Π΅Π³Π°ΠΌ Π·Π° ΠΏΠΎΠΌΠΎΡΡ Π² ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° Π΄Π»Ρ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ: ΡΡΠΊΠΎΠ²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π¦Π΅Π½ΡΡΠ° Π°ΠΊΡΡΠ΅ΡΡΡΠ²Π°, Π³ΠΈΠ½Π΅ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΏΠ΅ΡΠΈΠ½Π°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Π ΠΠΠ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΠΊΡ Π ΠΠΠ ΠΏΡΠΎΡΠ΅ΡΡΠΎΡΡ Π‘ΡΡ ΠΈΡ ΠΠ΅Π½Π½Π°Π΄ΠΈΡ Π’ΠΈΡ ΠΎΠ½ΠΎΠ²ΠΈΡΡ ΠΈ Π΅Π³ΠΎ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠ°ΠΌ Π·Π° ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΡ ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΡΡΠΊΠΎΠ²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈ ΡΡΡΠΎΠΌΠ°Π»ΡΡΠΉ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° ΠΠ°ΡΡΠ½ΠΎ-ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠΈΡΡΡΠ° ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΠΌ. Π. Π€. ΠΠ°ΠΌΠ°Π»Π΅ΠΈ Π ΠΠΠ Π΄.Π±.Π½. Π§Π°ΠΉΠ»Π°Ρ ΡΠ½Ρ Π ΡΠ±Π΅Π½Ρ ΠΠ°ΡΠΏΠΎΠ²ΠΈΡΡ ΠΈ Π΅Π³ΠΎ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠ°ΠΌ Π·Π° ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΡ ΠΊΡΠ»ΡΡΡΡ ΠΠ‘Π ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΡΡΠΊΠΎΠ²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΠΉΡΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΠ½ΡΡΠΈΡΡΡΠ° Π²ΡΡΡΠ΅ΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈ Π½Π΅ΠΉΡΠΎΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ Π ΠΠ Π΄.Π±.Π½. ΠΠΎΡΠ΅Π²ΠΎΠΉ ΠΠ»Π΅Π½Π΅ ΠΠ»Π°Π΄ΠΈΠΌΠΈΡΠΎΠ²Π½Π΅ ΠΈ Π΅Π΅ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠ°ΠΌ Π·Π° ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΈΡ ΡΠ΅ΡΡΠΎΠ².
ΠΠ°ΡΡΠΎΡΡΠ°Ρ ΡΠ°Π±ΠΎΡΠ° Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° ΠΏΡΠΈ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠ΅ Π³ΡΠ°Π½ΡΠΎΠ² Π Π€Π€Π № 02−04−48 153, Π Π€Π€Π № 05−04−48 031 ΠΈ ΠΡΠΎΠ³ΡΠ°ΠΌΠΌΡ «ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½Π°Ρ ΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½Π°Ρ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡ» ΠΡΠ΅Π·ΠΈΠ΄ΠΈΡΠΌΠ° Π ΠΠ.
ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅
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Π ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ 10-ΡΠΈ Π»Π΅Ρ Π² Π½Π΅ΠΉΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΎΡΠΎΠ±ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π±ΡΠ»ΠΎ ΠΏΡΠΈΠΊΠΎΠ²Π°Π½ΠΎ ΠΊ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π² Π¦ΠΠ‘. ΠΠ° ΡΡΠΎ Π²ΡΠ΅ΠΌΡ ΠΎΠΊΠΎΠ½ΡΠ°ΡΠ΅Π»ΡΠ½ΠΎ ΡΡΡΠ°Π½ΠΎΠ²ΠΈΠ»ΠΈΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΎ ΠΏΠΎΡΡΠΎΡΠ½Π½ΠΎΠΌ Π½Π΅ΠΉΡΠΎΠ³Π΅Π½Π΅Π·Π΅ Π²ΠΎ Π²Π·ΡΠΎΡΠ»ΠΎΠΌ ΠΌΠΎΠ·Π³Π΅ ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ . Π‘Π΅Π³ΠΎΠ΄Π½Ρ Π½ΠΈ Ρ ΠΊΠΎΠ³ΠΎ Π½Π΅ Π²ΡΠ·ΡΠ²Π°Π΅Ρ ΡΠΎΠΌΠ½Π΅Π½ΠΈΡ ΡΠΎ, ΡΡΠΎ Π² Π·ΡΠ΅Π»ΠΎΠΉ Π¦ΠΠ‘ Π² ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΡ ΠΎΠ±Π»Π°ΡΡΡΡ ΡΠΎΡ ΡΠ°Π½ΡΠ΅ΡΡΡ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΡ ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ, Π·Π° ΡΡΠ΅Ρ ΠΊΠΎΡΠΎΡΡΡ ΠΏΡΠΎΠΈΡΡ ΠΎΠ΄ΠΈΡ ΠΏΠΎΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ ΠΏΡΠ»Π° Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ² ΠΈ Π³Π»ΠΈΠΈ Π² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΌ ΠΌΠΎΠ·Π³Ρ. Π‘ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΡ ΡΠΎΡ ΡΠ°Π½Π΅Π½ΠΈΡ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ Π½Π΅ΠΉΡΠ°Π»ΡΠΏΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΊΠ°ΠΊ Π·ΡΠ΅Π»ΠΎΠ³ΠΎ, ΡΠ°ΠΊ ΠΈ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠ΅Π³ΠΎΡΡ ΠΌΠΎΠ·Π³Π° Π² ΠΊΡΠ»ΡΡΡΡΠ΅ Ρ Π½Π΅ΠΉΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΎΠ² ΠΏΠΎΡΠ²ΠΈΠ»ΡΡ Π½ΠΎΠ²ΡΠΉ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½Ρ Π΄Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π¦ΠΠ‘. ΠΠΎΠΌΠΈΠΌΠΎ ΡΡΠΎΠ³ΠΎ, Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΠ΅ ΠΊΡΠ»ΡΡΡΡΡ, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Ρ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ, ΡΠΏΠΎΡΠΎΠ±Π½ΡΡ Π΄Π°Π²Π°ΡΡ Π½Π°ΡΠ°Π»ΠΎ Π½Π΅ΠΉΡΠΎΠ½Π°ΠΌ ΠΈ Π³Π»ΠΈΠΈ, ΡΡΠ°Π»ΠΈ Π½ΠΎΠ²ΡΠΌ Π²ΠΈΡΠΊΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π² ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅ ΠΈΠ΅ΠΉΡΠΎΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ.
Π¨ΠΈΡΠΎΠΊΠΈΠΉ ΡΠΏΠ΅ΠΊΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ, ΡΡΠΎ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΡΡ ΠΎΠ±Π»Π°ΡΡΠ΅ΠΉ ΠΊΠ°ΠΊ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠ΅Π³ΠΎΡΡ, ΡΠ°ΠΊ ΠΈ Π·ΡΠ΅Π»ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ , Π²ΠΊΠ»ΡΡΠ°Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΏΡΠ΅ΠΊΡΠ°ΡΠ½ΠΎ ΡΠ°Π·ΠΌΠ½ΠΎΠΆΠ°ΡΡΡΡ Π² ΠΊΡΠ»ΡΡΡΡΠ΅, ΠΎΠ±ΡΠ°Π·ΡΡ Π½Π΅ΠΉΡΠΎΡΡΠ΅ΡΡ, Π½Π° Π±Π΅ΡΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΡΡ ΡΡΠ΅Π΄Π°Ρ Ρ ΠΌΠΈΡΠΎΠ³Π΅Π½Π°ΠΌΠΈ. ΠΡΡΠ΅ΠΌ ΠΊΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π΅ΠΉΡΠΎΡΡΠ΅Ρ ΡΠ΄Π°Π»ΠΎΡΡ ΡΠ±Π΅Π΄ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΡ, ΡΡΠΎ ΡΡΠΈ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΠ΅ ΠΊΡΠ»ΡΡΡΡΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Ρ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ. Π‘ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΡΠ»Π° Π²ΡΡΠ²Π»Π΅Π½Π° Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½Π°Ρ Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΡ ΡΡΠΈΡ ΠΊΡΠ»ΡΡΡΡ, ΡΡΠΎ, ΠΏΠΎ-Π²ΠΈΠ΄ΠΈΠΌΠΎΠΌΡ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ, Π²Ρ ΠΎΠ΄ΡΡΠΈΡ Π² ΡΠΎΡΡΠ°Π² ΠΊΡΠ»ΡΡΡΡΡ, ΠΎΠ±Π»Π°ΡΡΡΡ ΠΌΠΎΠ·Π³Π°, ΠΈΠ· ΠΊΠΎΡΠΎΡΠΎΠΉ ΠΎΠ½ΠΈ Π±ΡΠ»ΠΈ Π²ΡΠ΄Π΅Π»Π΅Π½Ρ, ΡΡΠ°Π΄ΠΈΠ΅ΠΉ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠΎΠ·Π³Π°, Π½Π° ΠΊΠΎΡΠΎΡΠΎΠΉ ΠΎΠ½ΠΈ Π±ΡΠ»ΠΈ Π²Π·ΡΡΡ Π΄Π»Ρ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΠΈ ΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ Π½Π° ΠΌΠΎΠΌΠ΅Π½Ρ ΠΏΠΎΡΠ΅Π²Π°. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΠ΅ΠΌ, ΡΡΠΎ ΠΊΡΠ»ΡΡΡΡΡ ΠΠ‘ΠΠ ΠΈΠΌΠ΅ΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ, Π²ΠΎΠ·Π½ΠΈΠΊΠ°Π΅Ρ Π²ΠΎΠΏΡΠΎΡ ΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π²ΡΡΠ°ΡΠΈΠ²Π°Π½ΠΈΡ ΠΈΡ in vitro ΠΈ ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. ΠΡΠΎΠ±Π΅Π½Π½ΠΎ ΡΡΠΎ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²Π°ΠΆΠ½ΡΠΌ Π΄Π»Ρ ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΠ΄Π΅ΡΡ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎ ΡΡΠΈΡΡΠ²Π°ΡΡ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ Π΄Π°Π½Π½ΡΠ΅ Π°Π½Π°Π»ΠΈΠ·Π° ΡΡΠΈΡ ΠΊΡΠ»ΡΡΡΡ in vitro, Π½ΠΎ ΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΡΡ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ .
Π‘ ΡΠ΅Ρ ΠΏΠΎΡ, ΠΊΠ°ΠΊ ΡΡΠ°Π»ΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎ Π½Π΅ΠΉΡΠΎΡΡΠ°Π½ΡΠΏΠ»Π°ΠΈΡΠ°ΡΠΈΠΈ Π²ΠΎΠΎΠ±ΡΠ΅, ΡΡΠΎΡ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π½Π΅ΠΉΡΠΎΠ΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. ΠΠΌΠ΅Π½Π½ΠΎ Π² ΡΡΠΎΡΠΎΠ½Ρ ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ Π² ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΠΌΠ΅ΡΡΠΈΠ»ΡΡ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ Π²ΡΠ΅Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ, Π·Π°Π½ΠΈΠΌΠ°ΡΡΠΈΡ ΡΡ Π½Π΅ΠΉΡΠΎΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠ΅ΠΉ, ΠΈ Π² ΡΡΠΎΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ ΠΎΡΠΎΠ±ΠΎΠ΅ ΠΌΠ΅ΡΡΠΎ Π·Π°Π½ΠΈΠΌΠ°Π΅Ρ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π½Π° ΠΌΠΎΠ΄Π΅Π»ΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΌΠΎΠ·Π³Π° Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ . Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΌΡ ΠΌΠΎΠΌΠ΅Π½ΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΈΠ· ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ ΠΠ‘ΠΠ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΌΠΎΠ³ΡΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠ΅ΡΠ΅ΠΆΠΈΠ²Π°ΡΡ ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² ΠΌΠΎΠ·Π³ Π³ΡΡΠ·ΡΠ½ΠΎΠ². ΠΠ½ΠΈ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠΈΡΡΡΡ, Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΡΡΡΡΡ ΠΈ ΠΌΠΈΠ³ΡΠΈΡΡΡΡ Π² ΡΠΊΠ°Π½ΡΡ ΠΌΠΎΠ·Π³Π° Ρ ΠΎΠ·ΡΠΈΠ½Π°. ΠΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ ΠΌΠΎΠ΄Π΅Π»ΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΌΠΎΠ·Π³Π° Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΉ, Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ»ΡΡΡΠ°Π΅ΡΡΡ ΠΊΠ°ΡΡΠΈΠ½Π° ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΠΎΡΡΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ², ΠΈ ΠΏΠΎΠ²ΡΡΠ°Π΅ΡΡΡ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½Π½ΡΡ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ².
ΠΠ°ΡΡΠΎΡΡΠ΅Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅, ΠΊΠΎΡΠΎΡΠΎΠ΅ Π±ΡΠ»ΠΎ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΎ Π½Π° ΡΠΎ, ΡΡΠΎΠ±Ρ Π² ΡΠ°ΠΌΠΊΠ°Ρ ΠΎΠ΄Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΠΏΡΠΎΠ²Π΅ΡΡΠΈ Π°Π½Π°Π»ΠΈΠ· ΡΠ°Π·Π²ΠΈΡΠΈΡ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² ΠΊΡΠ»ΡΡΡΡΠ΅ ΡΠΊΠ°Π½ΠΈ ΠΈ ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² ΠΌΠΎΠ·Π³ Π²Π·ΡΠΎΡΠ»ΡΡ ΠΊΡΡΡ, ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠΈ Π²ΡΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΡ ΡΡΡΠΏΠ΅Π½Π·ΠΈΠΉ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΠΈΠ· ΡΠΊΠ°Π½Π΅ΠΉ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° 912-ΡΠΈ Π½Π΅Π΄Π΅Π»Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ, Π² Π±Π΅ΡΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΡΡ ΡΡΠ΅Π΄Π°Ρ Ρ ΠΌΠΈΡΠΎΠ³Π΅Π½Π°ΠΌΠΈ Π² ΠΊΡΠ»ΡΡΡΡΠ°Ρ ΡΠΎΡΠΌΠΈΡΡΡΡΡΡ Π°Π³ΡΠ΅Π³Π°ΡΡ ΡΡΠ΅ΡΠΎΠΈΠ΄Π°Π»ΡΠ½ΠΎΠΉ ΡΠΎΡΠΌΡ — Π½Π΅ΠΉΡΠΎΡΡΠ΅ΡΡ. ΠΠΎ ΠΌΠ΅ΡΠ΅ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π΅ΠΉΡΠΎΡΡΠ΅ΡΡ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°ΡΡΡΡ Π² ΡΠ°Π·ΠΌΠ΅ΡΠ°Ρ Π·Π° ΡΡΠ΅Ρ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π² Π½ΠΈΡ . ΠΠ½ΡΡΡΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ Π½Π΅ΠΉΡΠΎΡΡΠ΅Ρ Π²ΡΡΠ²Π»ΡΡΡΡΡ ΠΈΠ΅ΠΉΡΠΎΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΠΎΠ·Π΅ΡΠΊΠΎ-ΠΏΠΎΠ΄ΠΎΠ±Π½ΡΠ΅ ΡΡΡΡΠΊΡΡΡΡ. ΠΠ΅ ΡΠΌΠΎΡΡΡ Π½Π° ΠΆΠ΅ΡΡΠΊΠΈΠ΅ ΡΡΠ»ΠΎΠ²ΠΈΡ ΡΡΠ΅Π΄Ρ, Π² Π½Π΅ΠΉΡΠΎΡΡΠ΅ΡΠ°Ρ ΠΏΡΠΎΠΈΡΡ ΠΎΠ΄ΠΈΡ ΡΠΏΠΎΠ½ΡΠ°Π½Π½Π°Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠ° ΠΊΠ»Π΅ΡΠΎΠΊ, ΡΡΠΎ Π±ΡΠ»ΠΎ Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΠΏΡΠΈ ΠΎΠΊΡΠ°ΡΠΊΠ΅ Π½Π° Π±Π΅Π»ΠΊΠΈ, ΠΌΠ°ΡΠΊΠΈΡΡΡΡΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΡΡΠ°ΠΏΡ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ. ΠΠΎΠ»Π΅Π΅ Π΄Π΅ΡΠ°Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· Π½Π΅ΠΉΡΠΎΡΡΠ΅Ρ, ΠΏΡΠΈΠΊΡΠ΅ΠΏΠ»Π΅Π½Π½ΡΡ ΠΊ ΠΏΠΎΠΊΡΠΎΠ²Π½ΡΠΌ ΡΡΠ΅ΠΊΠ»Π°ΠΌ, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ» ΡΠ΄Π΅Π»Π°ΡΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΡΠΎΡΡΠ°Π²ΠΈΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΠΎΠ± ΠΈΡ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ. Π’Π°ΠΊ, Π±ΡΠ»ΠΎ Π²ΡΡΡΠ½Π΅Π½ΠΎ, ΡΡΠΎ ΡΠΎΡΡ ΠΊΡΠ»ΡΡΡΡΡ ΠΠ‘ΠΠ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅ΡΡΡ Π·Π° ΡΡΠ΅Ρ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ , ΠΏΡΠΎΠ³Π΅ΠΏΠΈΡΠΎΡΠΏΡΡ ΠΈ Π³Π»ΠΈΠ°Π»ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΡΠΈ ΡΡΠΈ ΡΠΈΠΏΠ° ΠΊΠ»Π΅ΡΠΎΠΊ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΡΡ ΡΠΈΡΠΎΠΊΠΎΠ΅ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·ΠΈΠ΅ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΡΠΌ, ΠΈ, ΠΊΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΠΌΠ°ΡΠΊΠΈΡΡΡΡΠΈΠ΅ ΠΈΡ Π±Π΅Π»ΠΊΠΈ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½Π½Ρ ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎ Π² ΠΎΠ΄Π½ΠΎΠΉ ΠΊΠ»Π΅ΡΠΊΠ΅. Π ΠΎΡΠ»ΠΈΡΠΈΠ΅ ΠΎΡ Π½ΠΈΡ Π½Π΅ΠΉΡΠΎΠ±Π»Π°ΡΡΡ ΠΈΠΌΠ΅ΡΡ ΡΡΠΊΠΎ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡ, ΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΠ΅ΠΌΡΠ΅ ΠΈΠΌΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΡ Π½Π΅ ΠΏΠ΅ΡΠ΅ΠΊΡΡΠ²Π°ΡΡΡΡ Ρ Π΄ΡΡΠ³ΠΈΠΌΠΈ, ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ Π² ΡΡΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π° ΠΏΡΠ΅Π΄ΠΌΠ΅Ρ ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΡ Π² Π½Π΅ΠΉΡΠΎΡΡΠ΅ΡΠ°Ρ ΠΊΠ»Π΅ΡΠΎΠΊ Π½Π΅Π½Π΅ΠΉΡΠ°Π»ΡΡΠ³ΠΎ ΠΏΡΠΎΠΈΡΡ ΠΎΠΆΠ΄Π΅Π½ΠΈΡ, ΠΊΠ°ΠΊ, Π½Π°ΠΏΡΠΈΠΌΠ΅Ρ, ΡΠΈΠ±ΡΠΎΠ±Π»Π°ΡΡΠΎΠ², ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΠΉ ΡΠ΅Π·ΡΠ»ΡΡΠ°Ρ.
ΠΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΊΡΡΡΠ°ΠΌ Ρ ΠΌΠΎΠ΄Π΅Π»ΡΡ Π΄ΠΈΡΡΡΠ·Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΌΠΎΠ·Π³Π° (ΠΎΡΡΡΠ°Ρ Π³ΠΈΠΏΠΎΠΊΡΠΈΡ) ΠΊΠ»Π΅ΡΠΊΠΈ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ ΠΠ‘ΠΠ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²ΡΠ΅ΠΌΡ Π² Π±Π΅ΡΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΡΡΠ΅Π΄Π΅ Ρ ΠΠ€Π , Π€Π Π€-2ΠΈ ΠΠΠ€, ΠΏΠ΅ΡΠ΅ΠΆΠΈΠ²Π°ΡΡ ΠΊΠ°ΠΊ ΠΌΠΈΠ½ΠΈΠΌΡΠΌ 27 Π΄Π½Π΅ΠΉ Π±Π΅Π· ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² ΠΎΡΡΠΎΡΠΆΠ΅Π½ΠΈΡ. Π ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠ°Ρ Π±ΡΠ»ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΊΠ»Π΅ΡΠΊΠΈ, Π½Π°Ρ ΠΎΠ΄ΡΡΠΈΠ΅ΡΡ Π½Π° ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΡΠ°Π΄ΠΈΡΡ ΠΏΠ΅ΠΉΡΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ. ΠΠ΄Π½Π°ΠΊΠΎ, ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ² ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ Π½Π΅ Π±ΡΠ»ΠΎ. ΠΠ»Π΅ΡΠΊΠΈ ΡΠΎΡ ΡΠ°Π½ΡΡΡ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, Π½ΠΎ Π΅Π΅ ΡΡΠΎΠ²Π΅Π½Ρ Π³ΠΎΡΠ°Π·Π΄ΠΎ Π½ΠΈΠΆΠ΅, ΡΠ΅ΠΌ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ in vitro. Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΡ Π½ΠΈΠΊΠΎΠ³Π΄Π° Π½Π΅ ΠΎΡΠ΄Π΅Π»ΡΠ»ΠΈΡΡ Π³Π»ΠΈΠ°Π»ΡΠ½ΡΠΌ Π±Π°ΡΡΠ΅ΡΠΎΠΌ ΠΎΡ ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΠΊΠ°Π½ΠΈ. ΠΡΠ»ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΌΠΈΠ³ΡΠ°ΡΠΈΡ ΠΏΠ΅ΡΠ΅ΡΠ°ΠΆΠ΅Π½Π½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΡΠ΅ΡΠΈΠΏΡΠΎΠΊΠ½ΡΠΉ ΡΠΎΡΡ Π²ΠΎΠ»ΠΎΠΊΠΎΠ½ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠΊΠ°Π½ΡΠΌΠΈ Ρ ΠΎΠ·ΡΠΈΠ½Π° ΠΈ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠ°. Π ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΈΡ ΡΠ΅ΡΡΠ°Ρ Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ , ΠΏΠΎΠ»ΡΡΠΈΠ²ΡΠΈΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°Ρ, ΠΏΡΠΎΠΈΡΡ ΠΎΠ΄ΠΈΡ Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΠΌΠΈ Π³ΡΡΠΏΠΏΠ°ΠΌΠΈ. ΠΠ° ΡΠΎΠΌ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ, ΡΡΠΎ Π² ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠ°Ρ Π½Π΅ Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ², Π±ΡΠ»ΠΎ ΡΠ΄Π΅Π»Π°Π½ΠΎ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ ΠΎ Π½Π΅ΠΉΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΊΡΠ»ΡΡΡΡΡ ΠΠ‘ΠΠ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΠ΅ΠΉΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠΉ ΠΌΠΎΡΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΏΠΎΠΊΠ°Π·Π°Π» Π»ΡΡΡΡΡ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ² Π² Π³ΡΡΠΏΠΏΠ΅ ΠΊΡΡΡ Ρ ΠΎΡΡΡΠΎΠΉ Π³ΠΈΠΏΠΎΠΊΡΠΈΠ΅ΠΉ, ΠΏΠΎΠ»ΡΡΠΈΠ²ΡΠΈΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°Ρ. Π‘Π΅ΡΠΈΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΎΠ² Ρ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠ΅ΠΉ Π² ΠΌΠΎΠ·Π³ ΠΈΠ½ΡΠ°ΠΊΡΠ½ΡΡ ΠΈ Π³ΠΈΠΏΠΎΠΊΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΊΡΡΡ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ ΠΠ‘ΠΠ, Π²ΡΡΠ°ΡΠ΅Π½Π½ΠΎΠΉ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΡΠΎΡΠΊΠΎΠ³ΠΎ ΡΡΠΎΠΊΠ° Π½Π° Π±Π΅ΡΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΡΡΠ΅Π΄Π΅ Ρ ΠΠ€Π ΠΈ Π€Π Π€-2, Π½Π΅ Π²ΡΡΠ²ΠΈΠ»Π° Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠ°Π·Π»ΠΈΡΠΈΠΉ Π² ΠΏΠ΅ΡΠ΅ΠΆΠΈΠ²Π°Π½ΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π² Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΌ ΠΈ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½Π½ΠΎΠΌ ΠΌΠΎΠ·Π³Π΅. ΠΠ΄Π½Π°ΠΊΠΎ, Π² ΡΠΎΠΆΠ΅ Π²ΡΠ΅ΠΌΡ, Π΅ΡΠ»ΠΈ ΡΡΠ°Π²Π½ΠΈΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΡΠΎΠΉ ΡΠ΅ΡΠΈΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΎΠ² Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌΠΈ ΠΏΠ΅ΡΠ΅ΠΆΠΈΠ²Π°Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ, ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎ Ρ ΡΡΠ΅ΠΌΡ ΠΌΠΈΡΠΎΠ³Π΅Π½Π°ΠΌΠΈ, ΠΌΠΎΠΆΠ½ΠΎ ΡΠΊΠ°Π·Π°ΡΡ, ΡΡΠΎ Π½Π° ΡΡΠ΄ΡΠ±Ρ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΏΡΠ΅Π΄Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ.
Π‘ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Π² ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΠ΅ΠΎΡΠΈΠΈ ΠΎ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΊΠ°Ρ , ΠΏΡΠΈΡΡΡΡΡΠ²ΡΡΡΠΈΡ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π²ΠΎ Π²ΡΠ΅Ρ ΠΎΡΠ³Π°Π½Π°Ρ ΠΈ ΡΠΊΠ°Π½ΡΡ , ΠΏΠΎΡΠ²ΠΈΠ»Π°ΡΡ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΡ «ΠΏΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ», Ρ. Π΅. ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π΄Π°Π½Π½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π΄Π°Π²Π°ΡΡ Π½Π΅ ΡΠΈΠΏΠΈΡΠ½ΡΠ΅ Π΄Π»Ρ ΡΠ΅Π±Ρ Π²Π΅ΡΠ²ΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅ΡΠΈΡΠΎΠ²ΠΊΠΈ. Π’Π°ΠΊ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡΡΡ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ Π½Π΅ΠΉΡΠ°Π»ΡΠ½ΡΡ Π΄ΠΈΡΡΠ΅ΡΠ½ΡΠΈΡΠΎΠ²ΠΊΡ ΠΌΠΎΠ³ΡΡ Π΄Π°Π²Π°ΡΡ ΠΌΠ΅Π·Π΅Π½Ρ ΠΈΠΌΠΏΡΠ΅ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΡΡΡΠΎΠΌΡ ΠΊΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΊΠ°ΠΊ in vitro, ΡΠ°ΠΊ ΠΈ ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ. Π§ΡΠΎΠ±Ρ ΠΏΡΠΎΠ²Π΅ΡΠΈΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΡΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, Π² Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΡΠ½Π°ΡΠ°Π»Π° ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π»ΠΈ ΠΊΡΠ»ΡΡΡΡΡ ΠΠ‘Π ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, Π° Π·Π°ΡΠ΅ΠΌ ΠΏΡΠΎΠ²Π΅Π»ΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΡΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ Π² ΠΌΠΎΠ·Π³ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ ΠΈ Π³ΠΈΠΏΠΎΠΊΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΊΡΡΡ. ΠΡΠΈ ΡΡΠΎΠΌ, Π·Π΄Π΅ΡΡ ΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈΡΡ ΡΠ΅ΠΌΠΈ ΠΆΠ΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ, ΡΡΠΎ ΠΈ Π² ΡΠ»ΡΡΠ°Π΅ Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ ΠΠ‘ΠΠ Π² ΠΊΡΠ»ΡΡΡΡΠ΅ ΠΈ ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ ΠΊΡΠ»ΡΡΡΡΠ° ΡΠΎΡΡΠΎΠΈΡ Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΌ ΠΈΠ· ΡΠΈΠ±ΡΠΎΠ±Π»Π°ΡΡΠΎΠ². ΠΠ»Π΅ΡΠΎΠΊ Ρ Π½Π΅ΠΉΡΠ°Π»ΡΡΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΎΠΉ Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π½Π΅ Π±ΡΠ»ΠΎ. ΠΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠ΅ΡΠ°Π΄ΠΊΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΊΡΠ»ΡΡΡΡΡ ΠΠ‘Π Π² ΠΌΠΎΠ·Π³ ΠΊΡΡΡ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΡΡΡΠ°Ρ ΡΠ΅Π·ΠΎΡΠ±ΡΠΈΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ² Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π³Π»ΠΈΠ°Π»ΡΡΠ³ΠΎ ΡΡΠ±ΡΠ°. ΠΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠΎ ΠΏΠ΅ΠΉΡΠ°Π»ΡΠΏΠΎΠΌΡ ΠΏΡΡΠΈ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΠΌΠΈΠΊΡΠΎΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΡ ΠΌΠΎΠ·Π³Π° ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠ° Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π½Π΅ Π±ΡΠ»ΠΎ. ΠΠ΅ΡΠ΅ΠΆΠΈΠ²Π°ΡΡΠΈΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΡΠΎΡ ΡΠ°Π½ΡΡΡ ΡΠ²ΠΎΠΉ ΡΠ΅Π½ΠΎΡΠΈΠΏ. ΠΠ½ΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΡΡ Π²ΠΈΠΌΠ΅Π½ΡΠΈΠ½ ΠΈ ΡΠΈΠ±ΡΠΎΠ½Π΅ΠΊΡΠΈΠ½. ΠΡΠΎΠ΄ΡΡΠΈΡΡΠ΅ΠΌΡΠΉ Π² ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠ°Ρ ΡΠΈΠ±ΡΠΎΠ½Π΅ΠΊΡΠΈΠ½ΠΎΠ²ΡΠΉ Π²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΠΌΠ°ΡΡΠΈΠΊΡ, Ρ ΠΎΠ΄Π½ΠΎΠΉ ΡΡΠΎΡΠΎΠ½Ρ, ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠΈΠ»ΡΠ½ΠΎΠΌΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΎΠΊΡΡΠΆΠ°ΡΡΠΈΡ ΡΠΊΠ°Π½Π΅ΠΉ, Π°, Ρ Π΄ΡΡΠ³ΠΎΠΉ, — ΠΏΡΠΎΠ²ΠΎΡΠΈΡΡΠ΅Ρ ΡΠΎΡΡ ΠΎΡΡΠΎΡΡΠΊΠΎΠ² Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ² ΠΌΠΎΠ·Π³Π° ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠ° Π² ΠΎΠ±Π»Π°ΡΡΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠ°.
Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, Π°Π½Π°Π»ΠΈΠ· ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π²ΠΎ ΠΌΠ½ΠΎΠ³ΠΎΠΌ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°Π΅Ρ ΡΠ°Π½Π΅Π΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅. ΠΠΎ, Π² ΡΠΎΠΆΠ΅ Π²ΡΠ΅ΠΌΡ, ΠΎΠ½ ΡΠ²Π½ΠΎ ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ, ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π½Π°Ρ Π·Π΄Π΅ΡΡ ΠΏΠ°Π½Π΅Π»Ρ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ², ΠΊΠΎΡΠΎΡΠ°Ρ Π°Π½Π°Π»ΠΎΠ³ΠΈΡΠ½Π° ΡΠ΅ΠΌ, ΡΡΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ»ΠΈΡΡ ΠΈ Π΄ΡΡΠ³ΠΈΠΌΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠΌΠΈ, ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠΉ Π΄Π»Ρ ΡΠΎΠ³ΠΎ, ΡΡΠΎΠ±Ρ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠΎΡΠ½ΠΎ ΠΏΠΎΠ»ΡΡΠΈΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΠΎ ΡΠΈΠΏΠ°Ρ ΠΊΠ»Π΅ΡΠΎΠΊ, ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΡ Π½Π΅ΠΉΡΠΎΡΡΠ΅ΡΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΊΡΠ»ΡΡΡΡ ΠΠ‘ΠΠ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ ΠΎΠ΄Π° Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ Π΄ΠΈΡΡΡΠ·Π½ΠΎΠ³ΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΌΠΎΠ·Π³Π°. ΠΠ΄Π½Π°ΠΊΠΎ, Π²ΠΎΠΏΡΠΎΡ ΠΎ ΡΠΎΠΌ, Π° ΠΊΠ°ΠΊΠΈΠ΅ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡ Π½Π΅ΠΉΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΈΡ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ² ΠΌΠΎΠ·Π³Π° ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠ°, ΠΎΡΡΠ°Π»ΡΡ Π·Π° ΡΠ°ΠΌΠΊΠ°ΠΌΠΈ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ. Π, Π½Π°ΠΊΠΎΠ½Π΅Ρ, ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΊΡΠ»ΡΡΡΡΡ ΠΠ‘Π ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° in vitro ΠΈ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π² ΠΌΠΎΠ·Π³ ΠΊΡΡΡ ΡΠ²Π½ΠΎ ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ, ΡΡΠΎ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠ²ΡΠ·ΡΠ²Π°ΡΡ Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΎΠΉ ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΠΏΠΎΠΏΡΠ»ΡΡΠΈΡΡ ΠΠ‘Π ΠΏΠΎ Π½Π΅ΠΉΡΠ°Π»ΡΡΠΌΡ ΠΏΡΡΠΈ, ΡΠ²Π»ΡΡΡΡΡ ΠΏΡΠ΅ΠΆΠ΄Π΅Π²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌΠΈ, Π° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΡΠ΅Π±ΡΡΡ Π²Π½ΠΈΠΌΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ²Π΅ΡΠΊΠΈ ΠΈ, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ, ΠΏΠ΅ΡΠ΅ΡΠΌΠΎΡΡΠ°.
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- ΠΠ»Π΅ΠΊΡΠ°Π½Π΄ΡΠΎΠ²Π° Π.Π., ΠΠΈΡΠΌΠ°Π½ Π‘. Π. «ΠΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ Π½Π΅ΠΎΠΊΠΎΡΡΠΈΠΊΠ°Π»ΡΠ½ΡΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ², ΠΏΠΎΠΌΠ΅ΡΠ΅Π½Π½ΡΡ Π² Π·ΡΠΈΡΠ΅Π»ΡΠ½ΡΡ ΠΊΠΎΡΡ Π²Π·ΡΠΎΡΠ»ΡΡ ΠΊΡΡΡ», ΠΠΎΠΊΠ»Π°Π΄Ρ Π ΠΠ, 1995, Ρ. 340, № 5, Ρ. 705−708.
- ΠΠ»Π΅ΠΊΡΠ°Π½Π΄ΡΠΎΠ²Π° Π.Π., ΠΠΎΠ»Π΅ΠΆΠ°Π΅Π² JI.B. «Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΌΠΎΠ·Π³Π° Π² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΉ ΠΌΠΎΠ·Π³ ΠΊΡΡΡ», ΠΠΎΠΊΠ»Π°Π΄Ρ ΠΠ Π‘Π‘Π‘Π , 1982, Ρ. 263, № 2, Ρ. 460−463.
- ΠΠ»Π΅ΠΊΡΠ°Π½Π΄ΡΠΎΠ²Π° Π.Π., ΠΠΎΠ»Π΅ΠΆΠ°Π΅Π² Π. Π., Π§Π΅ΡΠΊΠ°ΡΠΎΠ²Π° J1.B. «ΠΠ»Π»ΠΎΡΡΠ°Π½ΡΠΏΠ»Π°ΠΏΡΠ°ΡΠΈΡ Π΄ΠΈΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠΎΠ·Π³Π° Π² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΉ ΠΌΠΎΠ·Π³ Π²Π·ΡΠΎΡΠ»ΡΡ ΠΊΡΡΡ, ΠΈΠ½ΡΠ°ΠΊΡΠ½ΡΡ ΠΈ ΠΏΠΎΡΠ»Π΅ Π³ΠΈΠΏΠΎΠΊΡΠΈΠΈ», ΠΠΎΠΊΠ»Π°Π΄Ρ ΠΠ Π‘Π‘Π‘Π , 1984, Ρ. 275, № 5, Ρ. 1190−1193.
- ΠΡΠ°Π³ΠΈΠ½ Π.Π., ΠΠΈΠ½ΠΎΠ³ΡΠ°Π΄ΠΎΠ²Π° Π. Π‘. «ΠΠΎΠΌΠΎ- ΠΈ Π³Π΅ΡΠ΅ΡΠΎΠ²ΠΈΠ΄ΠΎΠ²Π°Ρ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ», ΠΡΠ»Π»Π΅ΡΠ΅Π½Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ, 1981, Ρ. 92, № 10, Ρ. 486−489.
- ΠΠΎΠΌΠΎΠ½ΡΠΎΠ²ΠΈΡ Π.Π. «ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΏΠΎ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅ ΠΏΡΠΈΡΠΏΠΎΡΠΎΠ±Π»Π΅Π½ΠΈΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΠΊ Π³ΠΈΠΏΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΡΠΌΠ΅ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ», ΠΠ²ΡΠΎΡΠ΅Ρ. Π΄ΠΈΡ.. Π΄-ΡΠ° ΠΌΠ΅Π΄. Π½Π°ΡΠΊ. Π., 1957, Π‘. 24.
- ΠΠΎΡΠ΅Π²Π° Π.Π., ΠΠ»Π΅ΠΊΡΠ΅Π΅Π²Π° Π’. Π., ΠΠΎΡΠΎΠ±ΡΠ΅Π² Π. Π. «Π ΠΎΠ»Ρ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠ²ΠΎΠ³ΠΎ ΡΡΡΠ΅ΡΡΠ° Π² ΡΡΠ»ΠΎΠ²Π½ΠΎ-ΡΠ΅ΡΠ»Π΅ΠΊΡΠΎΡΠ½ΠΎΠΌ ΠΎΠ±ΠΎΡΠΎΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ Ρ ΠΊΡΡΡ Π»ΠΈΠ½ΠΈΠΈ ΠΠΈΡΡΠ°Ρ», Π’Π°Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΆΡΡΠ½Π°Π» ΠΏΡΠΈΡ ΠΈΠ°ΡΡΠΈΠΈ, 2002, Ρ. 6, № 2(19), Ρ. 47−48.
- ΠΠΎΠ»Π΅ΠΆΠ°Π΅Π² Π.Π., ΠΠ»Π΅ΠΊΡΠ°Π½Π΄ΡΠΎΠ²Π° Π. Π. «Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ ΡΠΊΠ°Π½ΠΈ ΠΌΠΎΠ·Π³Π° Π² Π½ΠΎΡΠΌΠ΅ ΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ», ΠΈΠ·Π΄. «ΠΠ°ΡΠΊΠ°», ΠΠΎΡΠΊΠ²Π°, 1986, Π‘. 152.
- ΠΠΎΠ»Π΅ΠΆΠ°Π΅Π² Π.Π., ΠΠ»Π΅ΠΊΡΠ°Π½Π΄ΡΠΎΠ²Π° Π. Π., ΠΠΈΡΠ²ΠΈΡΠΊΠΈΠΉ Π. Π., Π§Π΅ΡΠΊΠ°ΡΠΎΠ²Π° Π. Π. «Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ ΡΠΊΠ°Π½ΠΈ ΠΌΠΎΠ·Π³Π° Π² Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Π΅», ΠΈΠ·Π΄. «ΠΠ°ΡΠΊΠ°», ΠΠΎΡΠΊΠ²Π°, 1993, Π‘. 239.
- Π‘ΠΌΠΈΡΠ½ΠΎΠ² Π.Π., ΠΡΡΠΊΠΎΠ² Π. Π€., ΠΡΠ΅Π»Π»ΠΈΠ½ Π. Π. «ΠΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΎΠ·Π΅ΡΠΎΠΊ Π² ΡΠΊΡΠΏΠ»Π°Π½ΡΠ°ΡΠ°Ρ Π½Π΅ΠΎΠΊΠΎΡΡΠ΅ΠΊΡΠ° ΡΠΌΠ±ΡΠΈΠΎΠ½ΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° (ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎ-ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅)», ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡ, 1996, Ρ. 110, № 4, Ρ. 33−36.
- Adams R.J. «Metaphase spindles rotate in the neuroepithelium of rat cerebral cortex», The Journal of Neuroscience, 1996, vol. 16, no. 23, pp. 7610−7618.
- Alexandrova M.A., Polezhaev L.V. «Transplantation of various regions of embryonic tissue into the brain of adult rats», Journal fur Hirnforschung, 1984, vol. 25, no. l, pp. 89−98.
- Altman J. «Are neurons formed in the brains of adult mammals?», Science, 1962, vol. 135, pp. 1127−1128.
- Altman J. «Autoradiographic investigation of cell proliferation in the brains of rats and cats», The Anatomical Record, 1963, vol. 145, pp. 573−591.
- Altman J., Das G.D. «Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats», Journal of Comparative Neurology, 1965, vol. 124(3), pp. 319−335.
- Alvarez-Buylla A., Garcia-Verdugo J.M. «Neurogenesis in adult subventricular zone», The Journal of Neuroscience, 2002, vol. 22, no. 3, pp. 629−634.
- Auerbach J.M., Eiden M.V., McKay R.D.G. «Transplanted CNS stem cells form functional synapses in vivo», European Journal of Neuroscience, 2000, vol. 12, pp. 1696−1704.
- Azizi S.A., Stokes D., Augelli B.J., DiGirolamo C., Prockop D.J. «Engraftment and migration of human bone marrow stromal cells implanted in the brains af albino rats similarities to astrocyte grafts», PNAS, 1998, vol. 95, pp. 3908−3913.
- Baetge E.E. «Neural stem cells for CNS transplantation», Annals of the New York Academy of Sciences, 1993, vol. 695, pp. 285−291.
- Barker C.F., Billingham R.E. «Immunologically privileged sites», Advances in Immunology, 1977, vol. 25, pp. 1−54.
- Barker R.A., Widner H. «Immune problems in central nervous system cell therapy», The Journal of the American Society for Experimental NeuroTherapeutics, 2004, vol. 1, pp. 472−481.
- Barker-Cairns B.J., Sloan D.J., Broadwell R.D., Puklavec M., Charlton H.M. «Contribution of donor and host blood vessels in CNS allografts», Experimental Neurology, 1996, vol. 142, pp. 36−46.
- Baron K.D. «Axon reaction and central nervous system regeneration», In «Nerve, Organ and Tissue Regeneration: Research Perspectives», Seil F.J. (Ed), 1983, Academic Press, London, pp. 3−37.
- Bayer S.A., Yackel J.W., Puri P. S. «Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life», Science, 1982, vol. 216, pp.890−892.
- Bayer S.A. «3H-thymidine-radiographic studies of neurogenesis in the rat olfactory bulb», Experimental Brain Research, 1983, vol. 50, pp. 329−340.
- Benfey M., Aguayo A.J. «Extensive elongation of axons from rat brain into peripheral nerve grafts», Nature, 1982, vol. 256, pp. 150−152.
- Berry M. «Regeneration in the central nervous system», In «Recent Advances in Neuropathology», Thomas Smith W., Cavanagh J.B. (Eds), 1979, Churchill Livingstone, Edinburgh, pp. 67−111.
- Berry M., Riches A.C. «An immunological approach to regeneration in the central nervous system», British Medical Bulletin, 1974, vol. 30, pp. 135−140.
- Bez A., Corsini E., Curti D., Biggiogera M., Colombo A., Nicosia R.F., Pogano S.F., Parati E.A. «Neurosphere and neurosphere-forming cells: morphological an ultrastructural characterization», Brain Research, 2003, vol. 993, pp. 18−29.
- Billingham R.W., Boswell T. «Studies on the problem of corneal honografts», Proceedings of the Royal Society of London, Series B, Containing papers of a Biological character, Royal Society (Great Britain), 1953, vol. 141, pp. 392−406.
- Bjorklund A., Nilsson O.G., Kalen P. «Reafferentation of the subcortically denervated hippocampus as a model for transplant-induced functional recovery in the CNS», Progress in Brain Researc, 1990, vol. 83, pp. 411−426.
- Bjorklund A., Stenevi U. «Reformation of the several septohippocampal cholinergic pathway in the adult rat by transplanted septal neurons», Cell an Tissue Research, 1977, vol. 138, pp. 298−302.
- Bjorklund A., Stenevi U. «Reconstruction of brain circuitries by neural transplants», Trends in Neuroscience, 1979, vol. 2, no. 12, pp. 301−306.
- Bjorklund A., Stenevi U., Svendgaard N.-A. «Growth of transplanted monoaminergic neurons into adult hippocampus along the perforant path», Nature, 1976, vol. 262, no. 5571, pp. 787−790.
- Boenhoeffer T., Staiger V., Aertsen A. «Synaptic plasticity in rat hippocampal slice cultures: Local „Hebbian“ conjunction of pre- and postsynaptic stimulation leads to distributed synaptic enhancement», PNAS, 1989, vol. 86, pp. 8113−8117.
- Bragin A.G., Bohne A., Kitchigina V.F., Vinogradova O.S. «Functional integration of neurons in homotopic and heterotopic intracortical grafts with the host brain», Progress in Brain Research, 1990, vol. 82, pp. 287−300.
- Brock S.C., Bonsall J., Luskin M.B. «The neural progenitor cells of the forebrain subventricular zone: intrinsic properties in vitro and following transplantation», Methods: A Companion to Methods in Enzymology, 1998, vol. 16, pp. 268−281.
- Brundin P., Widner H., Nilsson O.G., Strecker R.E., Bjorklund A. «Intracerebral xenografts of dopamine neurons: the role of immunosuppression and blood-brain barrier», Experimental Brain Research, 1989, vol. 75, pp. 195−207
- Brustle O., Cyril Spiro A., Karram K., Choudhary K., Okabe S., McKay R.D.G. «In v/Vro-generated neural prcursors participate in mammalian brain development», PNAS, 1997, vol. 94, pp. 14 809−14 814.
- Bunge R.P., Bunge M.B. «Interrelationship between Schwann cell function and extracellular matrix production», Trends in Neuroscience, 1983, vol. 6, pp. 499 505.
- Bunge M.B. «Bridging areas of injury in the spinal cord», The Neuroscientist, 2001, vol. 7, no. 2, pp. 325−229.
- Cai J., Wu W., Mirua T., Pierce J.L., Lucero M.T., Albertine K.H., Spangrude G.J., Rao M.S. «Properties of fetal neural stem cell (NEP cell)», Developmental biology, 2002, vol. 251, pp. 221−240.
- Cameron H.A., Wolley C.S., McEwen B.S., Gould E. «Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat», Neuroscience, 1993a, vol. 56, pp. 337−344.
- Cameron H.A., Wolley C.S., Gould E. «Adrenal steroid receptor immunoreactivity in cells born in the adult rat dentate gyrus», Brain Research, 1993b, vol. 611, no. 2, pp. 342−346.
- Cameron H.A., McKay R.D. «Restoring production of hippocampal neurons in old age», Nature Neuroscience, 1999, vol. 2, no. 10, pp. 894−897
- Campbell K., Olsson M., Bjorklund A. «Regional incorporation and site-specific differentation of strial precursors transplanted to the embryonic forebrain ventricle», Neuron, 1995, vol. 15, pp. 1259−1273.
- Cao Q., Benton R.L., Whittemore S.R. «Stem cell repair of central nervous system injury», Journal of Neuroscience Research, 2002, vol. 68, 501−510.
- Carbonetto S. «The extracellular matrix of the nervous system», Trends in Neuroscience, 1984, vol. 7, pp. 382−387.
- Carpenter M.K., Xia Cui, Zhong-yi-Mu, Jackson J., Sherman S., Seiger A., Wahlberg L.U. «In vitro expansion of a multipotent population of a human neural progenitor cells», Experimental Neurology, 1999, vol. 158, pp. 265−278.
- Carpenter M.K., Inokuma M.S., Denham J., Mujtaba T., Chiu C.-P., Rao M.S. «Enrichment of neurons and neural precursors from human embryonic stem cells», Experimental Neurology, 2001, vol. 172, pp. 383−397.
- Cavanagh J.B. «The proliferation of astrocytes around a needle wound into rat brain», Journal of Anatomy, 1970, vol. 106, pp. 471−478.
- Chalmers-Redman R.M.E., Priestley T., Kemp J.A., Fine A. «In vitro propagation and inducible differentiation of multipotential progenitor cells from human brain», Neuroscience, 1997, vol. 76, no. 4. pp. 1121−1128.
- Chandran S., Compston A., Jauniaux E., Gilson J., Blackmore W., Svendsen C. «Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural progenitors», Glia, 2004, vol. 47, no. 4, pp. 314−324.
- Chen S.S., Revoltella R.P., Papini S., Michelini M., Fitzgerald W., Zimmerberg J., Margolis L. «Multilineage differentiation of rhesus monkey embryonic stem cells in three-dimensional culture systems», Stem Cells, 2003, vol. 21, no. 3, pp. 281−195.
- Chou Y.-H., Khuon S., Herrmann H., Goldman R.D. «Nestin promotes the phosphorylation-dependent disassembly of vimentin intermediate filaments during mitosis», Molecular Biology of the Cell, 2003, vol. 14, pp. 1468−1478.
- Corotto F.S., Henegar J.A., Maruniak J.A. «Neurogenesis persists in the subependymal layer of the adult mouse brain», Neuroscience Letters, 1993, vol. 149, pp. 111−114.
- Crutcher K.A. «Tissue sections from the mature rat brain and spinal cord as substrates for neurite outgrowth in vitro: extensive growth on gray matter but little on white matter», Experimental Neurology, 1989, vol. 104, pp. 39−54.
- Cunningham T.J., Sutilla C.B., Haun F. «Trophic effects of transplants following damage to cerebral cortex», Annals of the New York Academy of Sciences, 1987, vol. 495, pp. 153−168.
- Das G.D. «Transplantation of cerebelluar tissue in the cerebellum of neonate rabbits», Brain Research, 1973, vol. 50, pp. 170−173.
- Das G.D. «Differentiation of dendrites in the transplanted neuroblasts in the mammalian brain», Advances in Neurology, 1975, vol. 12, pp. 181−200.
- Das G.D. «Extraparechimal neural transplants: their cytology and survivability», Brain Research, 1982, vol. 241, pp. 182−186.
- Das G.D., Altman J. «Transplanted precursors of nerve cells: their fate in the cerebellums of young rats», Science, 1971, vol. 173, pp. 637−638.
- Das G.D., Altman J. «Studies on the transplantation of developing neural tissue in the mammalian brain. I. Transplantation of cerebelluar slabs into the cerebellum of neonate rats», Brain Research, 1972, vol. 38, pp. 233−249.
- Das G.D., Hallas B.H., Das K.G. «Transplantation of brain tissue in the brain of rat. I. Growth characteristics of neocortical transplants from embryos of different ages», American Journal of Anatomy, 1980, vol. 158, pp. 135−145.
- David S., Aguayo A.J. «Axonal elongation into peripheral nervous system bridges after CNS injury in adult rats», Science, 1981, vol. 214, pp. 931−933.
- Doetsch F., Garcia-Verdugo J.M., Alvarez-Buylla A. «Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain», The Journal ofNeuroscience, 1997, vol. 17, pp. 5046−5061.
- Doetsch F., Caile I., Lim D.A., Garcia-Verdugo J.M., Alvarez-Buylla A. «Subventricular zone astrocytes are neural stem cells in the adult mammalian brain», Cell, 1999, vol. 97, pp. 703−716.
- Doetsch F. «A niche for adult neural stem cells», Current Opinion in Genetics and Development, 2003, vol. 13, pp. 543−550.
- Doucette R. «Immunohistochemical localization of laminin, fibronectin and collagen type IV in the nerve fiber layer of olfactory bulb», International Journal of Developmental Neuroscience, 1996, vol. 14, pp. 945−959.
- Dunn E. «Primary and secondary finding in a series of attempts to transplant cerebral cortex in the albino rats», Journal of Comparative Neurology, 1917, vol. 27, pp. 565−582.
- Ehrlich P. «Das Sauezstoff-Bedurfniss des organismus: Eine farbenanalytischestudie», B.: Hirschwald, 1885.
- Eliasson C., Sahlgren C, Berthold C.-H., Stakeberg J., Celis C.E., Betsholtz C., Eriksson J.E., Pekny M. «Intermediate filament protein partnership in astrocytes», The Journal of Biological Chemistry, 1999, vol. 274, no. 34, pp. 23 996−24 006.
- Englund U., Bjorklund A., Wictorin K., «Migration patterns and phenotypic differentiation of long-term expanded human neural progenitor cells after transplantation into the adult rat brain», Developmental Brain Research, 2002a, vol. 134, pp. 123−141.
- Englund U., Bjorklund A., Wictorin K., Lindvall O., Kokaia M. «Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry», PNAS, 2002b, vol. 99, no. 6, pp. 17 089−17 094.
- Eriksson P. S., Perfilieva E., Bjork-Eriksson T., Alborn A.M., Nordborg C., Peterson D.A., Gage F.H. «Neurogenesis in the adult human hippocampus», Nature Medicine, 1998, vol. 4, pp.1313−1307.
- Fantie B.D., Kold B. «An examination of prefrontal lesion size and effects of cortical grafts on performance of the Morris water task by rats», Psychobiology, 1990, vol. 18, pp. 74−80.
- Fawcett J.W., Rokos J., Bakst I. «Oligodendrocytes repel axons and cause axonal growth cone collapse», Journal of Cell Science, 1989, vol. 92, pp. 93−100.
- Fishell G. «Strial precursors adopt cortical identities in response to local cues», Development, 1995, vol. 121, pp. 803−812.
- Forman F.S. «Axonal transport and nerve regeneration: A review», In «Spinal Cord Reconstruction», Kao C.C., Bunge R.P., Reier P.J. (Eds), 1983, Raven Press, New York, pp. 75−86.
- Franklin R.J.M., Blakemore W.F. «The peripheral nervous system central nervous system regeneration: a role for glial cell transplantation», Journal of Cell Science, 1990, vol. 95, pp. 185−190.
- Gage F. H, Coates P.W., Palmer T.D., Kuhn H.G., Fisher L.J., Suhonen J.O., Peterson D.A., Suhr S.T., Ray J. «Survival and differentiation of adult neural progenitor cells transplanted to the adult brain», PNAS, 1995a, vol. 92, pp. 11 879−11 883.
- Gage F.H., Ray J., Fisher L.J. «Isolation, characterization, and use of stem cells from the CNS», Annual Review of Neuroscience, 1995b, vol. 18, pp. 159−92.
- Glees P. «The differentiation of the brain and other tissues in an implanted portion of an embryonic head», Journal of Anatomy, 1940−1941, vol. 75., pp. 239−247.
- Gleeson J. G, Lin P.T., Flanagan L., Walsh C. «Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons», Neuron, 1999, vol. 23, pp.257−271.
- Goodel M.A., Brose K., Paradis B., Conner A.S., Mulligan R.C. «Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo», The Journal of Experimental Medicine, 1996, vol. 183, pp. 1797−1806.
- Goolsby J., Marty M.C., Heletz D., Chiappelli J., Tashko G., Yarnell D., Fishman P. S., Dhib-Jalbut S., Bever Jr. C.T., Pessac B., Trisler D. «Hematopoietic progenitors express neural genes», PNAS, 2003, vol. 100, no. 25, pp. 1 492 614 931.
- Gould E., Beylin A., Tanapat P., Reeves A., Shors T.J. «Learning enhances adult neurogenesis in the hippocampal formation», Nature Neuroscience, 1999, vol. 2, pp. 260−265.
- Gould E., Cameron H.A., Daniels D.C., Woolley C.S., McEwen B.S. «Adrenal hormones suppress cell division in the adult rat dentate gyrus», The Journal of Neuroscience, 1992, vol. 12, pp. 3642−3650.
- Gould E., Gross C.G. «Neurogenesis in adult mammals: some progress and problems», The Journal of Neuroscience, 2002, vol. 22, no. 3, pp. 619−623.
- Gould E., McEwen B.S., Tanapat P., Galea L.A.M., Fuchs E. «Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and
- NMDA receptor activation», The Journal of Neuroscience, 1997, vol. 17, pp. 2492−2498.
- Guan K., Chang H., Rolletshek A., Wobus A.N. «Embryonic stem cell-derived neurogenesis. Retinoic acid induction and lineage selection of neuronal cells», Cell and Tissue Research, 2001, vol. 305, pp. 171−176.
- Guest J.D., Rao A., Olson L., Bunge M.B., Bunge R.P. «The ability of human Schwann cell grafts to promote regeneration in the transected nude rate spinal cord», Experimental Neurology, 1997, vol. 148, pp. 502−522.
- Guth L. «Regeneration in the mammalian peripheral nervous system», Physiological Reviews, 1956, vol. 36,441−478.
- Hagan M., Wennersten A., Meijer X., Holmin S., Wahlberg L., Mathiesen T. «Neuroprotection by human neural progenitor cells after experimental contusion in rats», Neuroscience Letters, 2003, vol. 351, pp. 149−152.
- Hallbergson A.F., Gnateco C., Peterson D.A. «Neurogenesis and brain injury: managing a renewable resourse for repair», The Journal of Clinical Investigation, 2003, vol. 112, no. 8, pp. 1128−1133.
- Hammang J.P., Archer D.R., Duncan I.D. «Myelination following transplantation of EGF-responsive neural stem cells into a myelin-deficient environment», Experimental Neurology, 1997, vol. 147, pp. pp. 84−95.
- Harrison R.G. «Observations on the living developing nerve fibre», Journal of Experimental Zoology, 1907, vol. 9, pp. 787−846.
- Hastings N.B., Gould E. «Rapid extension of axons into the CA3 region by adult-generated granule cells», Journal of Comparative Neurology, 1999, vol. 413, pp. 146−154.
- Heinicke E.D., Kiernan J.A. «Vascular permeability and axon regeneration in skin auto-transplanted into the brain», Journal of Anatomy, 1978, vol. 125, pp. 409 420.
- Hickey W.F. «Basic principles of immunological surveillance of the normal central nervous system», Glia, 2001, vol. 36, pp. 118−124.
- Hickey W.F., Kimura H. «Perivascular microglial cells of the CNS are bone-marrow derived and present antigen in vivo», Science, 1988, vol. 239, pp. 290 292.
- Hitoshi S., Tropepe V., Ekker M., van der Kooy D. «Neural stem cell lineages are regionally specified, but not commited, within distinct compartments of the developing brain», Development, 2002b, vol. 129, pp. 233−244.
- Hoffer B.J., Olson L. «Ethical issue in brain-cell transplantation», Trends in Neuroscience, 1991, vol. 14, pp. 384−388.
- Hulspas R., Quesenberry P.J. «Characterization of neurosphere cell phenotypes by flow cytometry», Cytometry, 2000, vol. 40, pp. 245−250.
- Humpel C., Giacobini M., Wetmore C., Olson L. «Brain-derived neurotrophic factor and trkB receptor mRNAs in grafts of cortex cerebri», Experimental Neurology, 1994, vol. 127, no. 2, pp. 171−177.
- Humpel C., Stromberg I., Olson L. «Expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 mRNAs in human cortical xenografts», Journal of Neural Transplantation and Plasticity, 1995, vol. 5, pp. 257−264.
- Hung S.-C., Cheng H., Pan C.-Y., Tsai M.J., Kao L.-S., Ma H.L. «In vitro differentiation of size-sieved stem cells into electrically active neural cells», Stem Cells, 2002, vol. 20, pp. 522−529.
- Ide C., Tohyama K., Yokota R., Nitatori T., Onodera S. «Schwann cell basal lamina and nerve regeneration», Brain Research, 1983, vol. 288, pp. 61−75.
- Ishikawa R., Nishikori K., Furukawa S. «Appearance of nerve growth factor and acidic fibroblast growth factor with different time courses in the cavity-lesioned cortex of the rat brain», Neuroscience Letters, 1991, vol. 127, no. 1, pp. 70−72.
- Jaeger C.B., Lund R.D. «Transplantation of embryonic occipital cortex to the tectal region of newborn rats: a light microscopic study of organization and connective of transplants», Journal of Comparative Neurology, 1980, vol. 194, no. 3, pp. 571−597.
- Jain M., Armstrong R.J., Elneil S., Rosser A.E., Barker R.A. «Migration and differentiation of transplanted human neural precursor cells», Molecular Neuroscience, 2003a, vol. 14, no. 9, pp. 1257−1262.
- Jain M., Armstrong R.J., Tyers P., Barker R.A., Rosser A.E. «GABAergic immunoreactivity is predominant in neurons derived from expanded human neural precursor cells in vitro», Experimental Neurology, 2003b, vol. 182, no. 1, pp.113−123.
- Johansson C.B., Momma S., Clarke D.L., Risling M., Lendahl U., Frisen J. «Identification of a neural stem in adult mammalian central nervous system», Cell, 1999a, vol. 96, pp. 25−34.
- Johansson C.B., Svensson M., Wallstedt L., Janson A.M., Frisen J. «Neural stem cells in the adult human brain», Experimental Cell Research, 1999b, vol. 253, pp. 733−736.
- Johnson E.M. Jr., Tantuchi M., Distefano P. S. «Expression and possible function of nerve growth factor receptors», Trends in Neuroscience, 1988, vol. 11, pp. 299−304.
- Kalyani A., Hobson K., Rao M.S. «Neuroepithelial stem cells from the embryonic spinal cord: isolation, characterization and clonal analysis», Developmental Biology, 1997, vol. 186, pp. 202−223.
- Kaplan M.S., Bell D.H. «Neuronal proliferation in the 9-month-old rodent-radioautographic study of granule cells in the hippocampus», Experimental Brain Research, 1983, vol. 52, pp. 1−5.
- Kaplan M.S., Hinds J.W. «Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs», Science, 1977, vol. 197, pp. 1092−1094.
- Kato T., Honmou O., Uede T., Hashi K., Kocsis J.D. «Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord», Glia, 2000, vol. 30, pp. 209−218.
- Kavvaja M.D., Gage F.H. «Morphological and neurochemical features of cultured primary skin fibroblasts of Fischer 344 rats following striatal implantation», Journal of Comparative Neurology, 1992, vol. 317, no. 1, pp. 102−116.
- Kearns S.M., Laywell E.D., Kukekev V.K., Steindler D.A. «Extracellular matrix effects on neurosphere motility», Experimental Neurology, 2003, vol. 182, pp. 240−244.
- Kempermann G. «Why new neurons? Possible functions of adult hippcampal neurogenesis», The Journal of Neurosciece, 2002, vol. 22, no. 3, pp. 635−638.
- Kempermann G., Kuhn H.G., Gage F.H. «More hippocampal neurons an adult mice living in an enriched environment», Nature, 1997, vol. 386, pp. 493−495.
- Kim M., Morshead C.M. «Distinct populations of forebrain neural stem an progenitor cells can be isolated using side-population analysis», The Journal of Neuroscience, 2003, vol. 23, no. 33, pp. 10 703−10 709.
- Kopen G.C., Prockop D.J., Phinney D.G. «Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains», PNAS, 1999, vol. 96, pp. 10 711−10 716.
- Kornack D.R., Rakic P. «Continuation of neurogenesis in the hippocampus of the adult macaque monkey», PNAS USA, 1999, vol. 96, pp. 5768−5773.
- Kuhn H.G., Dickinson-Anson H., Gage F.H. «Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation», The Journal Neuroscience, 1996, vol. 16, pp. 2027−2033.
- Kuhn H.G., Winkler J., Kempermann G., Thai L.J., Gage F.H. «Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in adult rat brain», The Journal of Neuroscience, 1997, vol. 17, no. 15, pp. 58 205 829.
- Layer P.G., Robitzki A., Rothermel A., Willbold E. «Of layres and spheres: the reaggregate approach in tissue engineering», Trends in Neuroscience, 2002, vol. 25, no. 3, pp. 131−134.
- Laywell E.D., Kukekov V.G., Steindler D.A. «Multipotent neurospheres can be derived from forebrain subependymal zone and spinal cord of adult mice after protracted postmortem intervals», Experimental Neurology, 1999, vol. 156, pp. 430−433.
- Lendahl U., Zimmerman L.B., McKay R.D. «CNS stem cells express a new class of intermediate filament protein», Cell, 1990, vol. 60, no. 4, pp. 585−95.
- Lennington J.B., Yang Zh., Conover J.C. «Neural stem cells and regulation of adult neurogenesis», Reproductive Biology and Endocrinology, 2003, vol. 1, pp. 99−106.
- Li J., Sensebe L., Herve P., Charbord P. «Nontransformed colony-derived stromal cell lines from normal human marrows. II. Phenotypic characterization and differentiation pathway», Experimental Hematology, 1995, vol. 23, no. 2, pp. 133−141.
- Liesi P. «Laminin-immunoreactive glia distinguish regenerative adult CNS systems from non-regenerative ones», The EMBO Journal, 1985, vol. 4, pp. 25 052 511.
- Lillien L. «Neural progenitors and stem cells: mechanisms of progenitor heterogeneity», Current Opinion in Neurobiology, 1998, vol. 8, pp. 37−44.
- Lim D.A., Alvarez-Buylla A. «Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis», PNAS USA, 1999, vol. 96, pp. 7526−7531.
- Lim D.A., Tramontin A.D., Trevejo J.M., Herrera D.G., Garcia-Verdugo J.M., Alvarez-Buylla A. «Noggin antagonizes BMP signaling to create a niche for adult neurogenesis», Neuron, 2000, vol. 28, pp. 713−726.
- Lin L.F., Doherty D.H., Lile J.D., Bektesh S., Collins F. «GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons», Science, 1993, vol. 260, no. 5111, pp. 1072−1073.
- Ling Z.D., Potter E.D., Lipton J.W., Carvey P.M. «Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines», Experimental Neurology, 1998, vol. 149, pp. 411−423.
- Liuzzi F.J., Lasek R.J. «Astrocytes block axonal regeneration in mammals by activating the physiological stop pathway», Science, 1987, vol. 237, no. 4815, pp. 642−645.
- Lois C., Alvarez-Buylla A. «Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia», PNAS USA, 1993, vol. 90, pp. 2074−2077.
- Lois C., Alvarez-Buylla A. «Long-distance neuronal migration in the adult mammalian brain», Science, 1994, vol. 264, pp. 1145−1148.
- Lois C., Garcia-Verdugo J.M., Alvarez-Buylla A. «Chain migration of neuronal precursors», Science, 1996, vol. 271, pp. 978−981.
- Louissaint A.Jr., Rao S., Leventhal C., Gouldman S.A. «Coordinated interaction of neurogenesis and angiogenesis in adult songbird brain», Neuron, 2002, vol. 34, pp. 945−960.
- Lund R.D., Hauschka S.D. «Transplanted neural tissue develops connection with host brain», Science, 1976, vol. 193, pp. 582−584.
- Lundberg C., Martinez-Serrano A., Cattaneo E., McKay R.D.G., Bjorklund A. «Survival, integration, and differentiation of neural stem cell lines after transplantation to the adult rat striatum», Experimental Neurology, 1997, vol. 145, pp. 342−360.
- Lundberg C., Englund U., Trono D., Bjorklund A., Wictorin K. «Differentiation of the RN33B cell line into forebrain projection neurons after transplantation into the neonatal rat brain», Experimental Neurology, 2002, vol. 175, pp. 370−387.
- Luskin M.B. «Restricted proliferation and migration of postnatally penetrated neurons derived from the forebrain subventricular zone», Neuron, 1993, vol. 11, pp. 173−189.
- Magavi S.S., Leavitt B.R., Macklis J.D. «Induction of neurogenesis in the neocortex of adult mice», Nature, 2000, vol. 405, pp. 951−955.
- Markakis E.A., Gage F.H. «Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles», Journal of Comparative Neurology, 1999, vol. 406, pp. 449−460.
- Martinez-Serrano A., Bjorklund A. «Immortalized neural progenitor cells for CNS repair», Trends in Neuroscience, 1997, vol. 20, pp. 530−538.
- Mason H.A., Ito S., Corfas G. «Extracellular signals that regulate the tangential migration of olfactory bulb neuronal precursors: inductors, inhibitors and repellents», The Journal of Neuroscience, 2001, vol. 21, pp. 7654−7663
- Matthews M.A., Duncan D. «A quantitative study of morphological changes accompanying the initiation and progress of myelin production in the dorsal funiculus of the rat spinal cord», Journal of Comparative Neurology, 1971, vol. 142, pp. 1−22.
- McMahon J.A., Takada S., Zimmerman L.B., Fan C.-M., Harland R.M., McMahon A.P. «Noggin-mediated antagonism of BMP signaling is required for growth and pattering of the neural tube and somite», Genes and Development, 1998, vol. 12, pp. 1438−1452.
- Menezes J.R.L., Smith C.M., Nelson K.C., Luskin M.B. «The division of neuronal progenitor cells during migration in the neonatal mammalian forebrain», The Molecular and Cellular Neuroscience, 1995, vol. 6, pp. 496−508.
- Messam C.A., Hou J., Major E.O. «Coexpression of nestin in neural and glial cells in the developing human CNS defined by a human-specific anti-nestin antibody», Experimental Neurology, 2000, vol. 161, pp. 585−596.
- Messam C.A., Hou J., Berman J.W., Major E.O. «Analysis of the temporal expression of nestin in human fetal brain derived neuronal and glial progenitor cells», Developmental Brain Research, 2002, vol. 134, pp. 87−92.
- Mokry J., Subrtova D., Nemecek S. «Differentiation of epidermal growth factor-responsive neural precursor cells within neurospheres», Acta Medica, 1996, vol. 39, no. l, pp. 7−20.
- Munoz-Elias G., Marcus A.J., Coyne T.M., Woodburry D., Black I.B. «Adult bone marrow stromal cells in embryonic brain: engraftment, migration, differentiation, and long-term survival», The Journal of Neuroscience, 2004, vol. 24, no. 19, pp. 4585−4595.
- Murayama A., Matsuzaki Y., Kawaguchi A., Shimazaki T., Okano H. «Flow cytometric analysis of neural stem cells in the developing and adult mouse brain», Journal of Neuroscience Research, 2002, vol. 69, pp. 837−847.
- Nakano K., Migta M., Mochizuki H., Shimada T. «Differentiation of transplanted bone marrow cells in the adult mouse brain», Transplantation, 2001, vol. 71, no. 12, pp. 1735−1740.
- Okano H. «Stem cell biology of the central nervous system», Journal of Neuroscience Research, 2002, vol. 69, pp. 698−707.
- Ostenfeld T., Joly E., Tai Y.-T., Peters A., Caldwell M., Jauniaux E., Svendsen C.N. «Regional specification of rodent and human neurospheres», Developmental Brain Research, 2002, vol.134, pp. 43−55.
- Palm K., Salin-Nordstron T., Levesque M.F., Neuman T. «Fetal and adult human CNS stem cells have similar molecular characteristics and developmental potential», Molecular Brain Research, 2000, vol. 78, pp. 192−192.
- Palmer T.D., Ray J., Gage F.H. «FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain», Molecular and Cellular Neuroscience, 1995, vol. 6, pp. 474−486.
- Palmer T.D., Schwartz P.H., Taupin P., Kaspar B., Stein S.A., Gage F.H. «Cell culture: progenitor cells from human brain after death», Nature, 2001, vol. 411, pp. 42−43.
- Palmer T.D., Willhoite A.R., Gage F.H. «Vascular niche for adult hippocampal neurogenesis», The Journal of Comparative Neurology, 2000, vol. 425, pp. 479 494.
- Pardo B., Honegger P. «Differentiation of rat strial embryonic stem cells in vitro: monolayer culture vs. three-dimensional coculture with differentiated brain cells», Journal of Neuroscience Research, 2000, vol. 59, pp. 504−512.
- Parmar M., Skogh C., Bjorklund A., Campbell K. «Regional specification of neurosphere cultures derived from subregions of the embryonic telencephalon», Molecular and Cellular Neuroscience, 2002, vol. 21, pp. 645−656.
- Peier P.J., Stensaas L.J., Guth L. «The astrocytic scar an impediment to regeneration in the central nervous system», In «Spinal Cord Reconstruction», Kao C.C., Bunge R.P., Reier P.J. (Eds.), 1983, Raven Press, New York, pp. 163 195.
- Perry V.H., Hume D.A., Gordon S. «Immunohistochemical localization of macrophages and microglia in the adult ant developing mouse brain», Neuroscience, 1985, vol. 15, pp. 331−326.
- Piersma A.H., Brockbank K.G., Ploemacher R.E., van Vliet E., Brakel-van Peer K.M., Visser P.J. «Characterization of fibroblastic stromal cells from murine bone marrow», Experimental Hematology, 1985, vol. 13, no. 4, pp. 237−243.
- Piper D.R., Mujtaba T., Rao M.S., Lucero M.T. «Immunohistochemical and physiological characterization of a population of cultured human neural precursors», The Journal of Neurophysiology, 2000, vol. 84, pp. 534−548.
- Priller J., Persons D.A., Klett F.F., Kempermann G., Kreutzberg G.W., Dirnag U. «Neurogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo», The Journal of Cell Biology, 2001, vol. 155, no. 5, pp. 733−738.
- Qian X., Davis A.A., Goderie S.K., Temple S. «FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells», Neuron, 1997, vol. 18, pp. 81−93.
- Rakic P. «Adult neurogenesis in mammals: An identity Crisis», The Journal of Neuroscience, 2002, vol. 22, no. 3, pp. 614−618.
- Ramon y Cajal S. «Degeneration and regeneration of the nervous system», Transl. and ed. by May R.M., 1928, vol. 1−2, London, Oxford University Press, Milford, 769 p.
- Rathjen F.G., Schachner M. «Immunocytological and biochemical characterization of new neuronal cell surface component (LI antigen) witch is involved in cell adhesion», EMBO Journal, 1984, vol. 3, pp. 1−10.
- Ray J., Gage F.H. «Neural stem cell isolation, characterization and transplantation», In «Modern Techniques in Neuroscience», Windhorst U., Johansson H. (Eds), Springer, 1999, Chapter. 11, pp. 339−360.
- Reier P.J. «Cellular transplantation strategies for spinal cord injury and transplantational neurobiology», The Journal of the American Society for Experimental NeuroTherapeutics, 2004, vol. 1, pp. 424−451.
- Renfranz P.J., Caningham M.G., McKey R.D. «Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain», Cell, 1991, vol. 66, no. 4, pp. 713−729.
- Reubinoff B.E., Pera M.F., Fong C.-Y., Trounson A.O., Bongso A. «Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro», Nature Biotechnology, 2000, vol. 18, pp. 399−404.
- Reubinoff B.E., Pera M.F., Vajta G., Trounson A.O. «Effective cryopreservation of human embryonic stem cells by the open pulled straw vitrification method», Human Reproduction, 2001, vol. 16, no. 10, pp. 2187−2194.
- Reynolds B.A., Tetzlaf W., Weiss S. «A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes», Journal of Neuroscience, 1992, vol. 12, pp. 4565−4574.
- Reynolds B.A., Weiss S. «Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system», Science, 1992, vol. 255, pp. 1707−1710.
- Reynolds B.A., Weiss S. «Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell», Developmental Biology, 1996, vol. 175, pp. 1−13.
- Richardson P.M., McGuiness U.M., Aguayo A.J. «Axons from CNS neurons regenerate into PNS graft», Nature, 1980, vol. 284, pp. 264−265.
- Roisen F.J., Klueber K.M., Lu C.L., Hatcher L.M., Dozier A., Shields C.B., Maguire S. «Adult human olfactory stem cells», Brain Research, 2001, vol. 890, pp. 11−22.
- Rubio F.J., Bueno C., Villa A., Navarro B., Martinez-Serrano A. «Genetically perpetuated human neural stem cells engraft and differentiate into the adult mammalian brain», Molecular and Cellular Neuroscience, 2000, vol. 16, pp. 1−13.
- Sanchez-Ramos J.R. «Neural cells derived from adult bone marrow and umbilical cord blood», Journal of Neuroscience Research, 2002, vol. 69, pp. 880−893.
- Sanes J.R. «Extracellular matrix molecules that influence neural development», Annual Review of Neuroscience, 1989, vol. 12, pp. 491−516.
- Santambrogio L., Belyanskaya S.L., Fischer F.R., Cipriani B., Brosnan C.F., Ricciardi-Castagnoli P., Stern L.J., Strominger J.L., Riese R. «Developmental plasticity of CNS microglia», PNAS, 2001, vol. 98, no. 11, pp. 6295−6300.
- Savio T., Schwab M.E. «Rat CNS white matter, but not gray matter, is nonpermissive neuronal cell adhesion and fiber outgrowth», The Journal of Neuroscience, 1989, vol. 9, pp. 1126−1133.
- Scharenberg C.W., Harkey M.A., Torok-Storb B. «The ABCG2 transporter is an efficient Hoechst 33 342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors», Blood, 2002, vol. 99, no. 2, pp. 507−512.
- Schinstine M., Iacovitty L. «5-Azacytidine and BDNF enhance the maturation of neurons derived from EGF-generated neural stem cells», Experimental Neurology, 1997, vol. 144, pp. 315−325.
- Schulz T.C., Palmarini G.M., Noggle S.A., Weiler D.A., Mitalipova M.M., Condie B.G. «Direct neuronal differentiation of human embryonic stem cells», BMC Neuroscience, 2003, vol. 4, article no. 27.
- Schwab M.E., Thoenen H. «Dissociated neurons regenerate into sciatic but not optic nerve explants in culture irrespective of neurotrophic factors», The Journal of Neuroscience, 1985, vol. 5, pp. 2415−2423.
- Seri B., Garcia-Verdugo J.M., McEwen B.S., Alvarez-Buylla A. «Astrocytes give rise to new neurons in the adult mammalian hippocampus», The Journal of Neuroscience, 2001, vol. 21, pp. 7526−7531.
- Sheen V.L., Arnold M.W., Wan Y., Macklis J.D. «Neural precursor differentiation following transplantation into neocortex is dependent on intrinsicdevelopment state and receptor competence», Experimental Neurology, 1999, vol. 158, pp. 47−62.
- Sheen V.L., Macklis J.D. «Targeted neocortical cell death in adult mice guides migration and differentiation of transplanted embryonic neurons», The Journal of Neuroscience, 1995, vol. 15, pp. 8378−8392.
- Sheffield J.B., Moscona A.A. «Electron microscopic analysis of aggregation of embryonic cells: the structure and differentiation of aggregates of neural retina cells», Developmental Biology, 1970, vol. 23, no. 1, pp. 36−61.
- Shen L.Y., Figurov A., Lu B. «Recent progress in studies of neurotropic factors and their clinical implications», Journal of Molecular Medicine, 1997, vol. 75, pp. 637−644.
- Shewan D., Berry M., Cohen J. «Extensive regeneration in vitro by early embryonic neurons on immature and adult CNS tissue», The Journal of Neuroscience, 1995, vol. 15, no. 3, pt. 1, pp. 2057−2062
- Shihabuddin L.S., Horner P.J., Ray J., Gage F.H. «Adult spinal cord stem cells generate neurons after transplantation in adult dentate gyrus», The Journal of Neuroscience, 2000, vol. 20, no. 23, pp. 87−27−8735.
- Shimazaki T., Shingo T., Weiss S. «The ciliary neurotrophic factor/leukemia inhibitory factor/gpl30 receptor complex operates in the maintenance of mammalian forebrain neural stem cells», The Journal of Neuroscience, 2001, vol. 21, pp. 7642−7653.
- Shingo T., Gregg C., Enwere E., Fujikawa H., Hassam R., Geary C., Cross J.C., «Weiss S. „Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin“, Science, 2003, vol. 299, no. 5603, pp. 117−120.
- Snyder E.Y., Yoon C., Flax J.D., Macklis J.D. „Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex“, PNAS, 1997, vol. 94, pp. 11 663−11 668.
- Smith A.G., Heath J.K., Donaldson D.D., Wong G.G., Moreau J., Stahl M., Rogers D. „Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides“, Nature, 1988, vol. 336, pp. 688−690.
- Song H., Stevens C.F., Gage F.H. „Astroglia induce neurogenesis from adult neural stem cells“, Nature, 2002, vol. 417, pp. 39−44.
- Stewart P.A., Clements C.A., Wiley M.J. „Revascularization of skin transplanted into brain: source of the graft endothelium“, Microvascular Research, 1984, vol. 28, pp. 113−124.
- Storch A., Paul G., Csete M., Boehm B.O., Carvey P.M., Kupsch A., Schwarz J. „Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells“, Experimental Neurology, 2001, vol. 170, pp. 317−325.
- Streilein W.J. » Tissue barrier, immunosuppressive microenvironments, and privileged sites: the eye’s point view", Regional Immunology, 1993, vol. 5, pp. 253−268.
- Studer L., Csete M., Lee S.-H., Kabbani N., Walikonis J., Wold B., McKay R. «Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen», The Journal of Neuroscience, 2000, vol. 20, no. 19, pp. 7377−7383.
- Studer L., Tabar V., McKay R.D. «Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats», Nature Neuroscience, 1998, vol. l, pp. 290−295.
- Suhonen J.O., Peterson D.A., Ray J., Gage F.H. «Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo», Nature, 1996, vol. 383, pp. 624−627.
- Suslov O.N., Kukekov V.G., Ignatova T.N., Steindler D.A. «Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres», PNAS, 2002, vol. 99, no. 22, pp. 14 506−14 511.
- Svendsen C.N., Caldwell M.A., Ostenfeld O. «Human neural stem cells: isolation, expansion and transplantation», Brain Pathology, 1999, vol. 9, pp. 499−513.
- Svendsen C.N., Skepper J., Rosser A.E., ter Borg M.G., Tyres P., Ryken T. «Restricted growth potential of rat neural precursors as compared to mouse», Developmental Brain Research, 1997b, vol. 99, pp. 153−158.
- Svendsen C.N., ter Borg M.G., Armstrong J.E., Rosser A.E., Chandran S., Ostenfeld T., Caldwell M.A. «A new method for the rapid and long term growth of human neural precursor cells», The Journal of Neuroscience Methods, 1998, vol. 85, pp. 141−153.
- Takahashi S., Reddy S.V., Dallas M., Devlin R., Chou J.Y., Roodman G.D. «Development and characterization of a human marrow stromal cell line that enhances osteoclast-like cell formation», Endocrinology, 1995, vol. 136, no. 4, pp. 1441−1449.
- Tanapat P., Hastings N.B., Reeves A.J., Gould E. «Estrogen stimulates a transient increase in number of new neurons in the dentate gyrus of the adult female rats», The Journal of Neuroscience, 1999, vol. 19, no. 14, pp. 5792−5801.
- Tarasenko Y.I., Yu Y., Jordan P.M., Bottenstein J., Wu P. «Effect of growth factors on proliferation and phenotypic differentiation of human fetal neural stem cells», The Journal of Neuroscience Research, 2004, vol. 78, no. 5, pp. 625−636.
- Taupin Ph., Gage F.H. «Adult neurogenesis and neural stem cells of the central nervous system in mammals», Journal of Neuroscience Research, 2002, vol. 69, pp. 745−749.
- Thomas L.B., Gates M.A., Steindler D.A. «Young neurons from the adult subependymal zone proliferate and migrate along an astrocyte, extracellular matrix-rich pathway», Glia, 1996, vol. 17, pp. 1−14.
- Thompson W.G. «Successful brain grafting», New York Medical Journal, 1890, vol. 51, pp. 701−702.
- Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waknitz M.A., Swiergiel J.J., Marshall V.S., Jones J.M. «Embryonic stem cell lines derived from human blastocysts», Science, 1998, vol. 282, no. 5391, pp. 1145−1147.
- Toma J.G., Akhavan M., Fernandes K.J.L., Barnabe-Heider F., Sadikot A., Kaplan D.R., Miller F.D. «Isolation of multipotent adult stem cells from the dermis of mammalian skin», Nature Cell Biology, 2001, vol. 3, pp. 778−784.
- Tondreau T., Lagneaux L., Dejeneffe M., Massy M., Mortier C., Delforge A., Bron D. «Bone marrow-derived mesenchymal stem cells already express specific neural proteins before any differentiation», Differentiation, 2004, vol. 72, no. 7, pp. 319−326.
- Topp K.S., Faddis B.T., Vijayan V.K. «Trauma-induced proliferation of astrocytes in the brains of young and aged rats», Glia, 1989, vol. 2, pp. 201−211.
- Tramontin A.D., Garcia-Verdugo J.M., Lim D.A., Alvarez-Buylla A. «Postnatal development of radial glia and ventricular zone (VZ): a continuum of neural stem cell compartment», Cerebral Cortex, 2003, vol. 13, pp. 580−587.
- Tropepe V., Sibilia M., Ciruna B.G., Rossant J., Wagner E.F., van der Kooy D. «Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon», Developmental Biology, 1999, vol. 208, pp. 166−188.
- Tuszynski M.H., Gage F.H. «Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery», PNAS, 1995, vol. 92, no. 10, pp. 4621−4625.
- Tuszynski M.H., Weinder N., McCormack M., Miller I., Powell H., Conner J. «Grafts of genetically modified Schwann cells to the spinal cord: survival, axon growth, and myelination», Cell Transplantation, 1998, vol. 7, pp. 187−196.
- Uchida N., Buck D.W., He D., Reitsma M.J., Masek M., Phan T.V., Tsukamoto A.S., Gage F.H., Weissman I.L. «Direct isolation of human central nervous system stem cells», PNAS, 2000, vol. 97, no. 26, pp. 14 720−14 725.
- Van Praag H., Cristie B.R., Sejnowski T.J., Gage F.H. «Running enhances neurogenesis, learning and long-term potentiation in mice», PNAS USA, 1999a, vol.96, 13 427−13 431.
- Van Praag H., Kempermann G., Gage F.H. «Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus», Nature Neuroscience, 1999b, vol. 2, pp. 266−270.
- Van Praag H., Schinder A.F., Cristie B.R., Toni N., Palmer T.D., Gage F.H. «Functional neurogenesis in the adult hippocampus», Nature, 2002, vol. 415, pp. 1030−1034.
- Vesvovi A.L., Snyder E.Y. «Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo», Brain Pathology, 1999, vol. 9, pp. 569−598.
- Vroemen M., Aigner L., Winkler J., Weidner N. «Adult neural progenitor cell grafts survive after acute spinal cord injury and integrate along axonal pathways», European Journal ofNeuroscience, 2003, vol. 18, pp. 743−751.
- Wall P.D., Eggcr M.D. «Formation of new connections in adult rat brains after partial deafferentation», Nature, 1971, vol. 232, pp. 542−545.
- Wang Y., Sheen V.L., Macklis J.D. «Cortical interneurons upregulate neurotrophin expression in response to targeted apoptotic degeneration of neighboring pyramidal neurons in vivo», Experimental Neurology, 1998, vol. 154, pp. 389−402.
- Weiss S., Dunne C., Hewson J., Wohl C., Wheatley M., Peterson A.C., Reynolds B.A. «Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular ncuroaxis», The Journal ofNeuroscience, 1996, vol. 16, pp. 75 997 609.
- Wells J., Victgc B.P., Wells D.G., Fiala M. «Repair of blood-brain barrier during the first week after septohippocampal transplants», Abstracts Society for Neuroscience, 1987, vol. 13, p. 287.
- Wichterle II., Garcia-Verdugo J.M., Alvarez-Buylla A. «Direct evidence for homotipic, glia-independent neuronal migration», Neuron, 1997, vol. 18, pp. 779 791.
- Wislet-Gcndcbien S., Leprince P., Moonen G., Rogister B. «Regulation of neural markers nesiin and GFAP expression by cultivated bone marrow stromal cells», Journal of Cell Science", 2003, vol. 116, no. 16, pp. 3295−3302.
- Wright L.S., Li J., Caldwell M.A., Wallace K., Johnson J.A., Svendsen C.N. «Gene expression in human neural stem cells: effects of leukemia inhibitory factor», Journal ofNeurochemistry, 2003, vol. 86, pp. 179−195.
- Wu P., Tarasenko E.I., Gu Y., Huang L.-Y.M., Coggeshall Yu Y. «Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat», Nature Neuroscience, 2002b, vol. 5, no. 12, pp. 1271−1278.
- Yandava B.D., Billinghurst L.L., Snyder E.Y. «„Global“ cell replacement is feasible via neural stem cell transplantation: evidence from the dismyelinated shiverer mouse brain», PNAS, 1999, vol. 96, pp. 7029−7034.
- Ying Q.-L., Stavridis M., Griffiths D., Li M., Smith A. «Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture», Nature Biotechnology, 2003, vol. 21, no. 2, pp. 183−186.
- Yoshida T., Takeuchi M. «Expression of fibronectin and laminin by different types of mouse glial cells cultured in a serum-free medium», Cytotechnology, 1991, vol. 7, no. 3, pp. 187−196.
- Zhou F.C., Kelley M.R., Chiang Y.H., Young P. «Three to four-old nonpassaged EGF-responsive neural progenitor cells: proliferation, apoptosis, and DNA-repair», Experimental Neurology, 2000, vol. 164, pp.200−208.
- Zhang S.-C., Wernig M., Duncan I.D., Brustle O., Thomson J.A. «/» vitro differentiation of transplantable neural precursors from human embryonic stem cells", Nature Biotechnology, 2001, vol. 19, pp. 1129−1133.
- Zhao X., Das A.V., Thoreson W.B., James J., Wattnem T.E., Rodrigues-Sierra J., Ahmad I. «Adult corneal limbal epithelium: a model for studying neural potential of non-neural stem cells/progenitors», Developmental Biology, 2002, vol. 250, pp. 317−331.