ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π²ΠΈΠ΄ΠΈΠΌΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ° Π½Π° Π΄ΡΠΎΠΆΠΆΠ΅Π²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ Ρ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ΠΌ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΡ ΠΏΠΎΡΡΠΈΡΠΈΠ½ΠΎΠ²
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ΅Π°ΠΊΡΠΈΠΉ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠ΅Π΅ΡΡ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΡΠΎΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ. ΠΠ»Ρ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π½ΠΈΡ ΡΠ°ΠΊΠΈΡ ΡΠ΅Π°ΠΊΡΠΈΠΉ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡ ΡΠ²Π΅Ρ, ΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡ ΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄. ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΠ°ΠΌΠΈ ΠΏΡΠΈ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ Π²ΠΈΠ΄ΠΈΠΌΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ° ΡΠ²Π»ΡΡΡΡΡ ΠΏΠΎΡΡΠΈΡΠΈΠ½Ρ. ΠΡ ΡΠΎΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡ ΠΎΡΠ½ΠΎΠ²Π°Π½Π° Π½Π° ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠΎΠ²Π°ΡΡ Π°ΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΎΡΠΌΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° (Π³Π»Π°Π²Π½ΡΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΡΠΈΠ½Π³Π»Π΅ΡΠ½ΡΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄), ΠΊΠΎΡΠΎΡΡΠ΅, ΡΠ΅Π°Π³ΠΈΡΡΡ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅
- ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- ΠΠ»Π°Π²Π° I. ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ
- 1. ΠΠΈΠ΄ΠΈΠΌΡΠΉ ΡΠ²Π΅Ρ. Π₯ΡΠΎΠΌΠΎΡΠΎΡΡ Π²ΠΈΠ΄ΠΈΠΌΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ°
- 2. Π Π΅Π°ΠΊΡΠΈΠΈ I ΠΈ II ΡΠΈΠΏΠ°
- 3. ΠΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΎΡΠΌΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° (ΠΠ€Π)
- 4. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΈΠΏΠ° ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ΅Π°ΠΊΡΠΈΠΉ
- ΠΠ»Π°Π²Π° II. Π€ΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ Π±ΠΈΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ» ΠΈ ΠΎΡΠ³Π°Π½Π΅Π»Π» ΠΊΠ»Π΅ΡΠΊΠΈ
- 1. ΠΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ΅ ΡΠΎΡΠΎΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΠ΅ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ²
- 2. Π€ΠΎΡΠΎΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ Π±Π΅Π»ΠΊΠΎΠ²
- 3. Π€ΠΎΡΠΎΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ Π±ΠΈΠΎΠΌΠ΅ΠΌΠ±ΡΠ°Π½
- 4. Π€ΠΎΡΠΎΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ Π½ΡΠΊΠ»Π΅ΠΈΠ½ΠΎΠ²ΡΡ ΠΊΠΈΡΠ»ΠΎΡ ΠΈ Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ°
- ΠΠ»Π°Π²Π° III. Π€ΠΎΡΠΎΠ²ΡΡΠ²Π΅ΡΠ°Π½ΠΈΠ΅ ΠΏΠΎΡΡΠΈΡΠΈΠ½ΠΎΠ²ΡΡ ΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΠΎΠ²
- ΠΠ»Π°Π²Π° IV. Π€ΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΈΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ². ΠΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΠΏΠΎΡΡΠΈΡΠΈΠ½Ρ
- 1. Π€ΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ
- 2. ΠΠΈΠΎΡΠΈΠ½ΡΠ΅Π· ΠΏΠΎΡΡΠΈΡΠΈΠ½ΠΎΠ²
- 3. Π Π΅Π³ΡΠ»ΡΡΠΈΡ Π±ΠΈΠΎΡΠΈΠ½ΡΠ΅Π·Π° ΠΏΠΎΡΡΠΈΡΠΈΠ½ΠΎΠ² ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅
- ΠΠ»Π°Π²Π° I. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΡ ΡΡΠ»ΠΎΠ²ΠΈΠΉ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΡ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΡ ΠΏΠΎΡΡΠΈΡΠΈΠ½ΠΎΠ² ΠΈ ΠΈΡ ΡΠΎΡΠΎΠΈΠ½Π°ΠΊΡΠΈΠ²ΠΈΡΡΡΡΠ΅ΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ
- ΠΠ»Π°Π²Π° II. Π€ΠΎΡΠΎΠ²ΡΡΠ²Π΅ΡΠ°Π½ΠΈΠ΅ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΎΠΏΠΎΡΡΠΈΡΠΈΠ½Π° IX
- ΠΠ»Π°Π²Π° III. Π€ΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ ΡΡΠ±ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΡΡΡΡΠΊΡΡΡ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ Ρ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ΠΌ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΎΠΏΠΎΡΡΠΈΡΠΈΠ½Π° IX ΠΡΠ²ΠΎΠ΄Ρ
ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π²ΠΈΠ΄ΠΈΠΌΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ° Π½Π° Π΄ΡΠΎΠΆΠΆΠ΅Π²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ Ρ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ΠΌ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΡ ΠΏΠΎΡΡΠΈΡΠΈΠ½ΠΎΠ² (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ΅Π°ΠΊΡΠΈΠΉ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠ΅Π΅ΡΡ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΡΠΎΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ. ΠΠ»Ρ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π½ΠΈΡ ΡΠ°ΠΊΠΈΡ ΡΠ΅Π°ΠΊΡΠΈΠΉ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡ ΡΠ²Π΅Ρ, ΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡ ΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄. ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΠ°ΠΌΠΈ ΠΏΡΠΈ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ Π²ΠΈΠ΄ΠΈΠΌΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ° ΡΠ²Π»ΡΡΡΡΡ ΠΏΠΎΡΡΠΈΡΠΈΠ½Ρ. ΠΡ ΡΠΎΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡ ΠΎΡΠ½ΠΎΠ²Π°Π½Π° Π½Π° ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠΎΠ²Π°ΡΡ Π°ΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΎΡΠΌΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° (Π³Π»Π°Π²Π½ΡΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΡΠΈΠ½Π³Π»Π΅ΡΠ½ΡΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄), ΠΊΠΎΡΠΎΡΡΠ΅, ΡΠ΅Π°Π³ΠΈΡΡΡ Ρ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π²Π°ΠΆΠ½ΡΠΌΠΈ ΠΌΠ°ΠΊΡΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»Π°ΠΌΠΈ, Π²ΡΠ·ΡΠ²Π°ΡΡ ΠΈΡ ΡΠΎΡΠΎΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΠ΅ ΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ².
ΠΠ½ΡΠ΅ΡΠ΅Ρ ΠΊ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΡΠ΅ΠΊΡΠΎΠ² Π² Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅ΡΠ΅ Π±ΡΠ» ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ ΠΈΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΠΌ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ Π² Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ΅ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ Π±ΠΎΠ»ΡΡΠΎΠΉ ΠΎΠ±ΡΠ΅ΠΌ Π΄Π°Π½Π½ΡΡ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΊΠ°ΠΊ ΡΠΊΠ·ΠΎΠ³Π΅Π½Π½ΡΡ , Ρ. Π΅. Π²Π²ΠΎΠ΄ΠΈΠΌΡΡ ΠΈΠ·Π²Π½Π΅, ΡΠ°ΠΊ ΠΈ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΡ , Ρ. Π΅. ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΡΠΌΡΡ ΡΠ°ΠΌΠΎΠΉ ΠΊΠ»Π΅ΡΠΊΠΎΠΉ, ΠΏΠΎΡΡΠΈΡΠΈΠ½ΠΎΠ² Π½Π° ΠΊΠ»Π΅ΡΠΊΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ (Ochsner, 1997; Oleinick and Evans, 1998).
Π ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π΅ Π΄Π΅ΡΡΡΠΈΠ»Π΅ΡΠΈΠ΅ ΠΈΠ½ΡΠ΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π»ΠΈΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΎΠ±Π»Π°ΡΡΠΈ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠΉ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ, ΡΡΠΎ ΡΠ²ΡΠ·Π°Π½ΠΎΡΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΈΡΠ»Π° ΡΡΠ°ΠΌΠΌΠΎΠ² ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ², ΡΡΡΠΎΠΉΡΠΈΠ²ΡΡ ΠΊ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΠΎΠΉ Ρ ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΡΠ΄Π° ΡΠΊΠ·ΠΎΠ³Π΅Π½Π½ΡΡ , Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΡ ΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΠΎΠ² Π°ΠΊΡΠΈΠ²Π½ΠΎ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡΡ Π½Π° Π±Π°ΠΊΡΠ΅ΡΠΈΡΡ (van der Meulen et al., 1997; Ramstad et al., 1997; Wainwright, 1998; Szocs et al., 1999). ΠΠΌΠ΅ΡΡΠ΅ Ρ ΡΠ΅ΠΌ ΡΡΠ½Π³ΠΈΡΠΈΠ΄Π½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠΎΡΠΎΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΠΌΠ°Π»ΠΎ. Π‘ΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ Π½Π΅Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΡΠ°Π±ΠΎΡ ilo ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ ΡΠΊΠ·ΠΎΠ³Π΅Π½Π½ΡΡ ΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΠΎΠ² (Paardekooper et al., 1995; Carre et al., 1999). Π ΡΠΎ ΠΆΠ΅ Π²ΡΠ΅ΠΌΡ ΠΎΡΡΡΡΡΡΠ²ΡΡΡ Π΄Π°Π½Π½ΡΠ΅ ΠΎΠ± ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΡ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΈ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΡΠ΅ΠΊΡΠΎΠ² Ρ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ, Π½Π°ΠΊΠΎΠΏΠΈΠ²ΡΠΈΡ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΠΏΠΎΡΡΠΈΡΠΈΠ½Ρ Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° ΠΈΡ Π±ΠΈΠΎΡΠΈΠ½ΡΠ΅Π·. ΠΡΡΠ°ΡΡΡΡ Π½Π΅ΠΏΡΠΎΡΡΠ½Π΅Π½Π½ΡΠΌΠΈ Π²ΠΎΠΏΡΠΎΡΡ ΠΊΠ°ΠΊ ΠΎ ΡΠ°ΠΌΠΎΠΉ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΠΎΡΠΎΠΈΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΡΠ°ΠΊΠΈΡ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ, ΡΠ°ΠΊ ΠΈ ΠΎ Π΅Π΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ°Ρ . 4.
ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ.
I. ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ΅Π°ΠΊΡΠΈΠΉ.
ΠΡΠ²ΠΎΠ΄Ρ.
1. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΈΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ Saccharomyces cerevisiae ΠΈ Candida guilliermondii Π²ΠΈΠ΄ΠΈΠΌΡΠΌ ΡΠ²Π΅ΡΠΎΠΌ ΠΌΠΎΠΆΠ½ΠΎ Π΄ΠΎΡΡΠΈΡΡ ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠ° Π±ΠΈΠΎΡΠΈΠ½ΡΠ΅Π·Π° ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΡ ΠΏΠΎΡΡΠΈΡΠΈΠ½ΠΎΠ² 5-Π°ΠΌΠΈΠ½ΠΎΠ»Π΅Π²ΡΠ»ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΈ/ΠΈΠ»ΠΈ Ρ Π΅Π»Π°ΡΠΈΡΡΡΡΠ΅Π³ΠΎ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ 2,2'-Π΄ΠΈΠΏΠΈΡΠΈΠ΄ΠΈΠ»Π°, ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΡΡΠ΅Π³ΠΎ ΠΏΠΎΡΠ»Π΅Π΄Π½ΡΡ ΡΡΠ°Π΄ΠΈΡ Π±ΠΈΠΎΡΠΈΠ½ΡΠ΅Π·Π° Π³Π΅ΠΌΠ°, Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΡΠ΅Π³ΠΎ Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ Π½Π°ΠΊΠ°ΠΏΠ»ΠΈΠ²Π°Π΅ΡΡΡ Π΅Π³ΠΎ Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΏΡΠΎΡΠΎΠΏΠΎΡΡΠΈΡΠΈΠ½ IX.
2. ΠΡΡΠ²Π»Π΅Π½ΠΎ ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠ΅ Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ Π΄Π²ΡΡ ΡΡΠ°ΠΊΡΠΈΠΉ ΠΏΡΠΎΡΠΎΠΏΠΎΡΡΠΈΡΠΈΠ½Π° IX, ΡΠ°Π·Π»ΠΈΡΠ°ΡΡΠΈΡ ΡΡ ΠΏΠΎ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠ°ΠΊΡΠΈΠΌΡΠΌΠ° ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ (625 ΠΈ 635 Π½ΠΌ).
3. ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Ρ ΡΠ°Π·Π»ΠΈΡΠΈΡ Π² ΡΠΎΡΠΎΠ²ΡΡΠ²Π΅ΡΠ°Π½ΠΈΠΈ ΠΊΠΎΡΠΎΡΠΊΠΎΠ²ΠΎΠ»Π½ΠΎΠ²ΠΎΠΉ ΠΈ Π΄Π»ΠΈΠ½Π½ΠΎΠ²ΠΎΠ»Π½ΠΎΠ²ΠΎΠΉ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΎΠΏΠΎΡΡΠΈΡΠΈΠ½Π° IX: Π±ΠΎΠ»ΡΡΠ°Ρ ΡΠΎΡΠΎΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΡ ΠΊΠΎΡΠΎΡΠΊΠΎΠ²ΠΎΠ»Π½ΠΎΠ²ΠΎΠΉ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ ΡΠ»ΡΠΎΡΠ΅ΡΡΠΈΡΡΡΡΠ΅Π³ΠΎ ΡΠΎΡΠΎΠΏΡΠΎΠ΄ΡΠΊΡΠ° ΠΏΡΠΈ ΡΠΎΡΠΎΠ²ΡΡΠ²Π΅ΡΠ°Π½ΠΈΠΈ Π΄Π»ΠΈΠ½Π½ΠΎΠ²ΠΎΠ»Π½ΠΎΠ²ΠΎΠΉ.
4. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ ΠΏΡΠΎΡΠΎΠΏΠΎΡΡΠΈΡΠΈΠ½Π° IX Π² ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π°Ρ ΠΊΠ»Π΅ΡΠΎΠΊ S. cerevisiae ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΈΡ ΡΠΎΡΠΎΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ½ΠΈΡΠ°Π΅ΠΌΠΎΡΡΠΈ, Π° Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ ΠΏΡΠΎΡΠΎΠΏΠΎΡΡΠΈΡΠΈΠ½Π° IX Π² ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΡΡ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΡΠΎΡΠΎΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΈΡ Π΄ΡΡ Π°Π½ΠΈΡ.
5. ΠΠ»Π΅ΡΠΊΠΈ S. cerevisiae, Π΄Π΅ΡΠΈΡΠΈΡΠ½ΡΠ΅ ΠΏΠΎ ΠΏΠΎΡΡΡΠ΅ΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΠΠΠ, Π±ΠΎΠ»Π΅Π΅ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½Ρ ΠΊ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π²ΠΈΠ΄ΠΈΠΌΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ° ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π΄ΠΈΠΊΠΈΠΌ ΡΡΠ°ΠΌΠΌΠΎΠΌ, ΡΡΠΎ ΠΌΠΎΠΆΠ΅Ρ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΠΎΠ²Π°ΡΡ ΠΎΠ± ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΎΡΠΎΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΠΠ Π² Π΄ΡΠΎΠΆΠΆΠ°Ρ Ρ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΎΡΠΎΠΏΠΎΡΡΠΈΡΠΈΠ½Π° IX.
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- ΠΡΡ ΠΎΠ²ΡΠΊΠΈΠΉ Π.Π―., ΠΠ°ΠΉΡΠ΅Π²Π° Π. Π., ΠΠΎΠ»ΡΠ»ΡΡ Π. Π. (1985) ΠΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΠ½ΡΠ΅Π· ΠΏΠΎΡΡΠΈΡΠΈΠ½ΠΎΠ². ΠΠ±Π·ΠΎΡΠ½Π°Ρ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ. Π‘Π΅ΡΠΈΡ V. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠ΅ΡΠΌΠ΅Π½ΡΠΎΠ², Π²ΠΈΡΠ°ΠΌΠΈΠ½ΠΎΠ², Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ, ΠΏΡΠ΅ΠΌΠΈΠΊΡΠΎΠ². Π.: ΠΠΠΠΠ‘ΠΠΠ’Π, 1−5.
- ΠΡΡΠΈΠ½ΠΎΠ²ΠΈΡ Π. Π., ΠΠΎΡΠ΅Π² Π. Π. (1988) ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΠΎΡΡΠΈΡΠΈΠ½ΠΎΠ² ΠΈ Ρ Π»ΠΎΡΠΈΠ½ΠΎΠ² Π΄Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠ²Π΅ΡΠ° Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΡ, ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ (ΠΏΠΎΠ΄ ΡΠ΅Π΄. Π ΡΠ±ΠΈΠ½Π° Π.Π.), Π.: ΠΠ°ΡΠΊΠ°, 123−130.
- ΠΡΠ°ΡΠ½ΠΎΠ²ΡΠΊΠΈΠΉ A.A. (ΠΌΠ».). (1988) ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΠΎΠ»Ρ ΡΠΈΠ½Π³Π»Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° Π² ΡΠΎΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ , ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ (ΠΏΠΎΠ΄ ΡΠ΅Π΄. Π ΡΠ±ΠΈΠ½Π° Π.Π.), Π.: ΠΠ°ΡΠΊΠ°, 23−40.
- ΠΡΠ°ΡΠ½ΠΎΠ²ΡΠΊΠΈΠΉ A.A. (ΠΌΠ».). (1998) Π€ΠΎΡΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΠΈΠ½Π³Π»Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° Π² ΡΠΎΡΠΎΠ±ΠΈΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΈΡΡΠ΅ΠΌΠ°Ρ , ΠΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ, 15, 530−548.
- ΠΠΎΡΠΎΠ³ΠΎΠ΄ΠΈΠ½ Π.Π. (1966) ΠΡΠΎΠ±Π»Π΅ΠΌΡ ΠΏΠΎΡΡΡΠ°Π΄ΠΈΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ, Π.: ΠΡΠΎΠΌΠΈΠ·Π΄Π°Ρ, 391 Ρ.
- ΠΠ°ΡΡΠΈ Π ., ΠΡΠ΅Π½Π½Π΅Ρ Π., ΠΠ΅ΠΉΠ΅Ρ Π., Π ΠΎΠ΄ΡΡΠ»Π» Π. (1993) ΠΠΈΠΎΡ ΠΈΠΌΠΈΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, Π.: ΠΠΈΡ, Ρ. 1.
- ΠΠ΅Π²Π΅ΡΠΎΠ² Π. Π., ΠΠΈΠ·Π΅ Π‘., Π₯Π΅Π±Π΅Ρ Π£. (1999) Π€ΠΎΡΠΎΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ ΡΠΎΡΠΎΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ° Π² Π»ΠΈΡΡΡΡΡ ΡΠ°ΡΡΠ΅Π½ΠΈΠΉ, ΠΎΠ±ΡΠ°Π±ΠΎΡΠ°Π½Π½ΡΡ 5-Π°ΠΌΠΈΠ½ΠΎΠ»Π΅Π²ΡΠ»ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠΉ ΠΈΠ»ΠΈ 2,2'-Π΄ΠΈΠΏΠΈΡΠΈΠ΄ΠΈΠ»ΠΎΠΌ, II ΡΡΠ΅Π·Π΄ Π±ΠΈΠΎΡΠΈΠ·ΠΈΠΊΠΎΠ² Π ΠΎΡΡΠΈΠΈ, ΠΠΎΡΠΊΠ²Π°, ΡΠ΅Π·ΠΈΡΡ Π΄ΠΎΠΊΠ»Π°Π΄ΠΎΠ², Ρ. III, ΡΡΡ. 1058.
- Π‘ΡΡΠ°Ρ ΠΎΠ²ΡΠΊΠ°Ρ Π.Π., ΠΠ»Π°ΡΠΎΠ²Π° Π. Π., Π€ΡΠ°ΠΉΠΊΠΈΠ½ Π. Π―. (1998) ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ Π² Π²ΠΈΠ΄ΠΈΠΌΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ ΡΠΏΠ΅ΠΊΡΡΠ°, ΠΠΈΠΎΡΠΈΠ·ΠΈΠΊΠ° 43, 447−452.77
- Π§Π΅ΡΠ½ΠΈΡΠΊΠΈΠΉ Π.Π., ΠΠΎΡΠΎΠ±Π΅ΠΉ Π. Π. (1988) Π€ΠΎΡΠΎΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½, ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ (ΠΏΠΎΠ΄ ΡΠ΅Π΄. Π ΡΠ±ΠΈΠ½Π° Π.Π.), Π.: ΠΠ°ΡΠΊΠ°, 102−111.
- Andrew T.L., Riley P.G., Dailey H.A. (1990) Regulation of heme biosynthesis in higher animals, Biosynthesis of heme and chlorophylls (Dailey H.A., ed.), McGrow-Hill Publishing company, N.Y., pp. 163−200.
- Atlante A., Quagliariello E., Passarella S., Moreno G. and Salet C. (1990) Carrier thiols are targets of Photofrin 2 photosensitization of isolated rat liver mitochondria, J. Photochem. Photobiol., B: Biol. 7, 21−32.78
- Bachowski G.J., Morehouse K.M. and Girotti A.W. (1988) Porphyrin-sensitized photoreactions in the presence of ascorbate: oxidation of cells membrane lipids and hydroxyl radical traps, Photochem. Photobiol. 47, 635−645.
- Bagdonas S., Ma L.W., Iani V., Rotomskis R., Juzenas P., Moan J. (2000) Phototransformations of 5-aminolevulinic acid-induced protoporphyrinIX in vitro: a spectroscopic study, Photochem. Photobiol. 72, 186−192.
- Bailis A.M., Maines S., Negritto M.T. (1995) The essential helicase gene RAD3 suppresses short-sequence recombination in Sciccharomyces cerevisiae, Mol. Cell Biol. 15, 3998−4008.
- Ball D.J., Mayhew S., Wood S.R., Griffiths J., Vernon D.I., Brown S.B. (1999) A comparative study of the cellular uptake and photodynamic efficacy of three novel zinc phthalocyanines of differing charge, Photochem. Photobiol. 69, 390−396.
- Bech O., Phillips D., Moan J., MacRobert A.J. (1997) A hydroxypyridinone (CP94) enhances protoporphyrin IX formation in 5-aminolaevulinic acid treated cells, J. Photochem. Photobiol. B: Biol. 41, 136−144.
- Beijersbergen van Henegouwen G.M. (1991) Systemic phototoxicity of drugs and other xenobiotics, J. Photochem. Photobiol. B: Biol. 10, 183−210.
- Berg K., Anholt H., Bech O., Moan J. (1996) The Influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells, Br. J. Cancer 74, 688−697.
- Berg K. and Moan J. (1994) Lysosomes as photochemical targets, Int. J. Cancer 59, 814−822.
- Berthiaume F., Reiken S.R., Toner M., Tompkins R.G., Yarmush M.L. (1994) Antibody-targeted photolysis of bacteria in vivo, Biotechnology 12, 703−706.
- Bertoloni G., Lauro F.M., Cortella G., Merchat M. (2000) Photosensitizing activity of hematoporphyrin on Staphylococcus aureus cells, Biochim. Biophys. Acta 1475, 169−174.79
- Bertoloni G., Reddi E., Gatta M., Burlini C., Jori G. (1989) Factors influencing the haematoporphyrin-sensitized photoinactivation of Candida albicans, J. Gen. Microbiol. 135 (Pt 4), 957−966.
- Bezdetnaya L., Zeghari N., Belitchenko I., Barberi-Heyob M., Merlin J.L., Potapenko A., Guillemin F. (1996) Spectroscopic and biological testing of photobleaching of porphyrins in solutions, Photochem, Photobiol. 64, 382−386.
- Boegheim J.P., Scholte H., Dubbelman T.M., Beems E., Raap A.K., van Steveninck J. (1987) Photodynamic effects of hematoporphyrin-derivative on enzyme activities of murine L929 fibroblasts, J. Photochem. Photobiol. B: Biol. 1, 61−73.
- Bogorad L. (1979) Biosynthesis of porphyrins In: Dolphin D (ed) The porphyrins, Academic Press, New York, 125−178.
- Borg D.C. and Schaich K.M. (1974) Cytotoxity from coupled redox cycling of autoxidizing xenobiotics and metals, Isr. J. Chem. 24, 38−53.
- Brun A. and Sandberg S. (1991) Mechanisms of photosensitivity in porphyric patients with special emphasis on erythropoietic protoporphyria, J. Photochem. Photobiol., B: Biol. 10, 285−302.
- Bussey M., Saville D., Chevallier M.R., Rank G.H. (1979) Yeast plasma membrane ghosts, Biochim. Biophys. Acta 553, 185−196.
- Camadro J.M., Ibraham N.G., Levere R.D. (1984) Kinetic studies of human liver ferrochelatase, Role of endogenous metals, J. Biol. Chem. 259, 5678−5682.
- Canistraro S. and van de Vorst A. (1977) Photosensitization by hematoporphyrin: ESR evidence for free radical induction in unsaturated fatty acids and for singlet oxygen production, Biochem. Biophys. Res. Commun. 74, 11 771 185.
- Carre V., Jayat C., Granet R., Krausz P., Guilloton M. (19 996) Chronology of the apoptotic events induced in the K562 cell line by photodynamic treatment with hematoporphyrin and monoglucosylporphyrin, Photochem. Photobiol. 69, 55−60.
- Casey W.M., Parks L.W. (1989) A role for sterols in the porphyrin mediated photosensitization of yeast, Photochem. Photobiol. 50, 553−556.81
- Ceckler T.L., Bryant R.G., Penney D.P. Gibson S.L. and Hilf R. (1986) 31P-NMR spectroscopy demonstrates decreased ATP levels in vivo as an early response to photodynamic therapy, Biochem. Biophys. Res. Commun. 140, 273−279.
- Csatorday K., MacColl R. and Berns D.S. (1981) Accumulation of Protoporphyrin and Zn-porphyrin in Cyanidium caldarium, Proc. Natl. Acad. Sei. USA, 78, 1700−1702.
- Cox R. and Charles H.P. (1973) Porphyrin-accumulating mutants of Escherichia coli, J. Bacteriology 113, 122−132.
- Dantas F.J., Moraes M.O., Carvalho E.F., Valsa J.O., Bernardo-Filho M., Caldeira-de-Araujo A. (1996) Lethality induced by stannous chloride on Escherichia coli AB 1157: participation of reactive oxygen species, Food Chem. Toxicol. 34, 959−962.
- Dellinger M. (1996) Apoptosis or necrosis following Photofrin photosensitization: influence of the incubation protocol, Photochem. Photobiol. 64, 182−187.
- Dellinger M., Ricchelli F., Moreno G., Salet C. (1994) Hematoporphyrin derivative (Photofrin) photodynamic action on Ca2+ transport in monkey kidney cells (CV-1), Photochem. Photobiol. 60, 368−372.
- Dietel W., Bolsen K., Dickson E., Fritsch C., Pottier R., Wendenburg R. (1996) Formation of water-soluble porphyrins and protoporphyrin IX in 5-aminolevulinic-acid-incubated carcinoma cells, J. Photochem. Photobiol. B: Biol. 33, 225−231.82
- Dixit R., Mukhtar H., Bickers D.R. (1983) Destruction of microsomal cytochrome P-450 by reactive oxygen species generated during photosensitization of hematoporphyrin derivative, Photochem. Photobiol. 37, 173−176.
- Dubbelman T.M., de Goeij A.F., Christianse K., van Steveninck J. (1981) Protoporphyrin-induced photodynamic effects on band 3 protein of human erythrocyte membranes, Biochim. Biophys. Acta 649, 310−316.
- Dubbelman T.M., de Goeij A.F., van Steveninck J. (1980) Protoporphyrin-induced photodynamic effects on transport processes across the membrane of human erythrocytes, Biochim. Biophys. Acta, 595, 133−139.
- Duez P., Hanocq M., Dubois J. (2001) Photodynamic DNA damage mediated by delta-aminolevulinic acid-induced porphyrins, Carcinogenesis 22, 771−778.
- Ehrenberg B., Malik Z., Nitzan Y. (1985) Fluorescence spectral changes of hematoporphyrin derivative upon binding to lipid vesicles, Staphylococcus aureus and Escherichia coli cells, Photochem. Photobiol. 41, 429−435.
- Eleouet S., Carre J., Vonarx V., Heyman D., Lajat Y., Patrice T. (1997) Delta-aminolevulinic acid-induced fluorescence in normal human lymphocytes, J. Photochem. Photobiol. B: Biol. 41, 22−29.
- Felix C.C., Reszka K. and Sealy R.C. (1983) Free radicals from photoreduction of hematoporphyrin in aqueous solution, Photochem. Photobiol. 37, 141−147.
- Fernandez J.M., Bilgin M.D., Grossweiner L.I. (1997) Singlet oxygen generation by photodynamic agents, J. Photochem. Photobiol. B: Biol. 37, 131−140.
- Ferreira G.C. and Gong J. (1995) 5-Aminolevulinate synthase and the first step of heme biosynthesis, J. Bioenerg. Biomembr. 27, 151−159.
- Ferreira G.C., Franco R., Lloyd S.G., Moura I., Moura J.J., Huynh B.H. (1995) Structure and function of ferrochelatase, J. Bioenerg. Biomembr. 27, 221 229.83
- Foote C.S. (1991) Definition of Type 1 and Type 2 photosensitized oxidation, Photochem. Photobiol. 54, 659.
- Foote C.S. (1976) Photosensitized oxidation and singlet oxygen: consequences in biological systems, in W.A.Pryor (ed.), Free radicals in biology, 2, Academic Press, New York, 85−134.
- Fraikin G.Ya., Strakhovskaya M.G., Rubin A.B. (1996) The role of membrane-bound porphyrin-type compound as endogenous sensitizer in photodynamic damage to yeast plasma membranes, J.Photochem. Photobiol. B: Biol. 34, 129−135.
- Fuchs C., Riesenberg R., Siegert J., Baumgartner R. (1997) pH-Dependent formation of 5-aminolaevulinic acid-induced protoporphyrin IX in fibrosarcoma cells, J. Photochem. Photobiol. B: Biol. 40, 49−54.
- Fuchs J., Weber S., Kaufmann R. (2000) Genotoxic potential of porphyrin type photosensitizers with particular emphasis on 5-aminolevulinic acid: implications for clinical photodynamic therapy, Free Radic. Biol. Med. 28, 537−548.
- Gantchev T.G., van Lier J.E. (1995) Catalase inactivation following photosensitization with tetrasulfonated metallophthalocyanines, Photochem. Photobiol. 62, 123−134.
- Georgakoudi I., Foster T.H. (1998) Singlet oxygen- versus nonsinglet oxygen-mediated mechanisms of sensitizer photobleaching and their effects on photodynamic dosimetry, Photochem. Photobiol. 67, 612−625.
- Girard P.M., Boiteux S. (1997) Repair of oxidized DNA bases in the yeast Saccharomyces cerevisiae, Biochimie 79, 559−566.
- Girotti A.W. (1992) Photosensitized oxidation of cholesterol in biologikal systems: reaction pathways, cytotoxic effects and defense mechanisms, J. Photochem. Photobiol. B: Biol. 13, 105−118.
- Girotti A.W. (1990) Photodynamic lipid peroxidation in biological systems, Photochem. Photobiol. 51, 497−509.
- Girotti A.W. (1985) Mechanisms of lipid peroxidation, J. Free Rad. Biol. Med. 1, 87−95.
- Girotti A.W. and Deziel M.R. (1983) Photodynamic action of protoporphyrin on resealed erythrocyte membranes: mechanisms of release of trapped markers, Adv. Exp. Med. Biol. 160, 213−225.
- Girotti A.W. and Thomas J.P. (1984) Superoxide- and hydrogen peroxid-depdndent lipid peroxidation in intact and tritondespersed erythrocyte membranes, Biochem. Biophys. Res. Commun. 118, 474−480.
- Girotti A.W., Bachowski G.J. and Jordan J.E. (1987) Lipid peroxidation in erythrocyte membranes: cholesterol peroxide analyses in photosensitized and xanthine oxidase-catalysed reactions, Lipids 22, 401−408.
- Sl.Gudgin Dickson E.F., Pottier R.H. (1995) On the role of protoporphyrin IX photoproducts in photodynamic therapy, J. Photochem. Photobiol. B: Biol. 29, 9193.
- Gutteridge J.M., Smith A. (1988) Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation, Biochem. J. 256, 861−865.
- Hellingwerf K.J., Hoff W.D., Crielaard W. (1996) Photobiology of microorganisms: how photosensors catch a photon to initialize signalling, Mol. Microbiol. 21, 683−693.
- Henderson B.W. and Dougherty T.J. (1992) How does photodynamic therapy work? Photochem. Photobiol., 55, 145−157.
- Hermes-Lima M. (1995) How do Ca2+ and 5-aminolevulinic acid-derived oxyradicals promote injury to isolated mitochondria? Free Radic. Biol. Med. 19, 381−390.
- Kennedy J.C. and Pottier R.H. (1992) Endogenous protoporthyrin 9, a clinically useful photo-sensitizer for photodynamic therapy, J.Photochem.Photobiol. B: Biol. 14, 275−292.86
- Kennedy J.C., Jin Y.-M. and Pottier R.H. (1990) Effect of extracellular pH upon the uptake of porphyrins by malignant cells, Photochem. Photobiol. 51 (Suppl.), 4S.
- Kessel D. and Luo Y. (1998) Mitochondrial photodamage and PDT-induced apoptosis, J. Photochem. Photobiol. B: Biol. 42, 89−95.
- Kessel D. and Rossi E. (1982) Determinants of porphyrin-sensitized photooxidation characterized by fluorescence and absorption spectra, Photochem. Photobiol. 35, 37−41.
- Kessel D. and Schulz V. (1990) Sites of photosensitization by protoporphyrin and tin protoporphyrin in leukemia L1210 cells, J. Photochem. Photobiol. B: Biol. 6, 87−92.
- Koller M.-E. and Romslo I. (1978) Studies on the uptake of porphyrin by isolated mitochondria, Biochim. Biophys. Acta 503, 238−250.
- Koller M.-E. and Romiso I. (1980) Uptake of proptoporphyrin 9 by isolated rat liver mitochondria, Biochim. J. 188, 329−335.
- Krammer B., Uberriegler K. (1996) In-vitro investigation of ALA-induced protoporphyrin IX, J. Photochem. Photobiol. B: Biol. 36, 121−126.
- Krammer B. (1999) Apoptosis induction by photodynamic treatment with endogenous protoporphyrin IX? 8th Congress of European Society for Photobiology, Granada, Spain, Book of Abstracts, P. 64.87
- Labbe-Bois R. and Labbe P. (1990) Tetrapyrrole and heme biosynthesis in the yeast Saccharomyces cerevisiae, Biosynthesis of heme and chlorophylls (Dailey H.A., ed.), McGrow-Hill Publishing company, N.Y., pp. 235−285.
- Lisby M., Rothstein R., Mortensen U.H. (2001) Rad 52 forms DNA repair and recombination centers during S phase, Proc. Natl. Acad. Sei. USA 98, 8276−8282.
- Luppa P., Jacob K., Ehret W. (1993) The production of porphyrins from delta-aminolaevulinic acid by Haemophilus parainfluenzae, J. Med. Microbiol. 39, 262 267.
- Ma L., Bagdonas S., Moan J. (2001) The photosensitizing effect of the photoproduct of protoporphyrin IX, J. Photochem. Photobiol. B: Biol. 60, 108−113.
- Malik Z., Kostenich G., Roitman L., Ehrenberg B., Orenstein A. (1995) Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice, J. Photochem. Photobiol. B: Biol. 28, 213−208.
- Malik Z., Lugaci H. (1987) Destruction of erythroleukaemic cells by photoactivation of endogenous porphyrins, Br. J. Cancer 56, 589−595.
- Madeo F., Frohlich E., Ligr M., Grey M., Sigrist S.J., Wolf D.H., Frohlich K.U. (1999) Oxygen stress: a regulator of apoptosis in yeast, J. Cell Biol. 145, 757 767.
- Madeo F., Frohlich E., Frohlich K.U. (1997) A yeast mutant showing diagnostic markers of early and late apoptosis, J. Cell Biol. 139, 729−734.88
- Mattoon J. and Balcavage W.X. (1967) Yeast mitochondria and submitochondrial particles, in: R.W.Estabrook, M.E.Pullman (Eds.), Metods in Enzymology, vol. 10, Academic Press, New York, 135−142.
- Midden W.R., Dahl T.A., Hartman P.E. (1987) Cytotoxity but no mutagenecityin bacteria with externally generated singlet oxygen, New directions in Photodynamic Therapy, SPIE 847, 122−126.
- Moan J. (1986) Effect of bleaching of porphyrin sensitisers during photodynamic therapy, Cancer Lett. 33, 43−53.
- Moan J. and Bagdonas S. (1999) Photodegradation and phototransformation of sensitizers during PDT- good or bad? 8th Congress of European Society for Photobiology, Granada, Spain, Book of Abstracts, P. 69.
- Moan J. and Berg K. (1991) The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen, Photochem. Photobiol. 53, 549 553.89
- Moan J., Streckyte G., Bagdonas S., Bech O., Berg K. (1997) Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid, Int. J. Cancer 70, 90−97.
- Nitzan Y., Gutterman M., Malik Z., Ehrenberg B. (1992) Inactivation of gram-negative bacteria by photosensitized porphyrins, Photochem. Photobiol. 55, 89−96.
- Nitzan Y., Ashkenazi H. (2001) Photoinactivation of Acinetobacter baumannii and Escherichia coli by a cationic hydrophilic porphyrin at various light wavelengths, Curr. Microbiol. 42, 408−414.
- Noodt B.B., Berg K., Stokke T., Peng Q., Nesland J.M. (1996) Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX, Br. J. Cancer 74, 22−29.
- Paardekooper M., van Gompel A.E., van Steveninck J., van den Broek P.J. (1995) The effect of photodynamic treatment of yeast with the sensitizer chloroaluminum phthalocyanine on various cellular parameters, Photochem. Photobiol. 62, 561−567.
- Penning L.C., Keirse M.J., van Steveninck J., Dubbelman T.M. (1993) Ca2±mediated prostaglandin E2 induction reduces haematoporphyrin-derivative-induced cytotoxicity of T24 human bladder transitional carcinoma cells in vitro, Biochem. J. 292, 237−240.
- Piette J. (1991) Biological consequences associated with DNA oxidation mediated by singlet oxigen, J. Photochem. Photobiol. B: Biol. 11, 241−260.
- Pourzand C., Reelfs O., Kvam E., Tyrrell R.M. (1999) The iron regulatory protein can determine the effectiveness of 5-aminolevulinic acid in inducing protoporphyrin IX in human primary skin fibroblasts, J. Invest. Dermatol. 112, 419−425.
- Radakovic-Fijan S., Rappersberger K., Tanew A., Honigsmann H., Ortel B. (1999) Ultrastructural changes in PAM cells after photodynamic treatment with delta-aminolevulinic acid-induced porphyrins or photosan, J. Invest. Dermatol. 112, 264−270.91
- Ramstad S., Futsaether C.M., Johnsson A. (1997) Porphyrin sensitization and intracellular calcium changes in the prokaryote Propionibacterium acnes, J. Photochem. Photobiol. B: Biol. 40, 141−148.
- Rebeiz N., Arkins S., Kelley K.W., Rebeiz C.A. (1996a) Enhancement of coproporphyrinogen III transport into isolated transformed leukocyte mitochondria by ATP, Arch. Biochem. Biophys. 333, 475−481.
- Rebeiz N., Arkins S., Rebeiz C.A., Simon J., Zachary J.F., Kelley K.W. (19 966) Induction of tumor necrosis by delta-aminolevulinic acid and 1,10-phenanthroline photodynamic therapy, Cancer Res. 56, 339−344.
- Rebeiz N., Rebeiz C.C., Arkins S., Kelley K.W., Rebeiz C.A. (1992) Photodestruction of tumor cells by induction of endogenous accumulation of protoporphyrin IX: enhancement by 1,10-phenanthroline, Photochem. Photobiol. 55, 431−435.
- Ricchelli F.J. (1995) Photophysical properties of porphyrins in biological membranes, J. Photochem. Photobiol. B: Biol. 29, 109−118.
- Ricchelli F., Barbato P., Milani ML, Gobbo S., Salet C., Moreno G. (1999) Photodynamic action of porphyrin on Ca2+ influx in endoplasmic reticulum: a comparison with mitochondria, Biochem. J. 338, 221−227.
- Rotenberg M. and Margalit R. (1987) Porphyrin-membrane interactions: binding or partition? Biochim. Biophys. Acta 905, 173−180.
- Rotomskis R., Streckyte G., Bagdonas S. (1997) Phototransformations of sensitizers 2. Photoproducts formed in aqueous solutions of porphyrins, J. Photochem. Photobiol. B: Biol. 39, 172−175.
- Salet C. and Moreno G. (1990) Photosensitization of mitochondria. Molecularand cellular aspects, J. Photochem. Photobiol. B: Biol. 5, 133−150.
- Sandberg S. and Romslo I. (1980) Porphyrin-sensitized photodynamic damageof isolated rat liver mitochondria, Biochem. Biophys. Acta 593, 187−195.
- Sandberg S., Gleite J., Hopen G., Solberg C.O., Romslo I. (1981) Porphyrininduced photodamage to isolated human neutrophils, Photochem. Photobiol. 34,471.475.
- Shevchuk I., Chekulayev V., Moan J., Berg K. (1996) Effects of the inhibitors of energy metabolism, lonidamine and levamisole, on 5-aminolevulinic-acid-induced photochemotherapy, Int. J. Cancer 67, 791−799.
- Sorensen R., Iani V., Moan J. (1998) Kinetics of photobleaching of protoporphyrin IX in the skin of nude mice exposed to different fluence rates of red light, Photochem. Photobiol. 68, 835−840.
- Soukos N.S., Ximenez-Fyvie L.A., Hamblin M.R., Socransky S.S., Hasan T. (1998) Targeted antimicrobial photochemotherapy, Antimicrob. Agents Chemother. 42, 2595−2601.
- Specht K.G., Rodgers M.A. (1991) Plasma membrane depolarization and calcium influx during cell injury by photodynamic action, Biochim. Biophys. Acta 1070, 60−68.
- Steenvoorden D.P., Beijersbergen van Henegouwen G.M. (1997) The use of endogenous antioxidants to improve photoprotection, J. Photochem. Photobiol. B: Biol. 41, 1−10.94
- Szocs K., Gabor F., Csik G., Fidy J. (1999) delta-Aminolaevulinic acid-induced porphyrin synthesis and photodynamic inactivation of Escherichia coli, J. Photochem. Photobiol. B: Biol. 50, 8−17.
- Valenzeno D.P. (1987) Photomodification of biological membranes with emphasis on singlet oxygen mechanisms, Photochem. Photobiol. 46, 147−160.
- Vance J.R., Wilson T.E. (2001) Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatases, Mol. Cell Biol. 21, 7191−7198.
- Verma A., Nye J.S. and Snyder S.H. (1987) Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepin receptor, Proc. Natl. Acad. Sci. USA, 84, 2256−2260.
- Verweij H., Dubbelman T.M., van Steveninck J. (1981) Photodynamic protein cross-linking, Biochim. Biophys. Acta 647, 87−94.
- Villanueva A., Canete M., Trigueros C., Rodriguez-Borlado L., Juarranz A. (1993) Photodynamic induction of DNA-protein cross-linking in solution by several sensitizers and visible light, Biopolymers 33, 239−244.
- Vincent S.H., Holeman B., Cully B.C., Muller-Eberhard U. (1986) Porphyrin-induced photodynamic cross-linking of hepatic heme-binding proteins, Life Sci. 38, 365−372.
- Wainwright M. (1998) Photodynamic antimicrobial chemotherapy (PACT), J. Antimicrob. Chem. 42, 13−28.
- Weizinan E., Rothmann C., Greenbaum L., Shainberg A., Adamek M., Ehrenberg B., Malik Z. (2000) Mitochondrial localization and photodamage during photodynamic therapy with tetraphenylporphines, J. Photochem. Photobiol. B: Biol. 59, 92−102.96
- Wilson M., Burns T., Pratten J. (1996) Killing of Streptococcus sanguis in biofilms using a light-activated antimicrobial agent, J. Antimicrob. Chemother. 37, 377−381.
- Wolfson S.J., Bartczak A., Bloomer J.R. (1979) Effect of endogenous heme generation on delta-aminolevulinic acid synthase activity in rat liver mitochondria, J. Biol. Chem. 254, 3543−3546.
- Zoladek T., Nguyen B.N., Jagiello I., Graczyk A., Rytka J. (1997) Diamino acid derivatives of porphyrins penetrate into yeast cells, induce photodamage, but have no mutagenic effect, Photochem. Photobiol. 66, 253−259.
- Zoladek T., Nguyen B.N., Rytka J. (1996) Saccharomyces cerevisiae mutants defective in heme biosynthesis as a tool for studying the mechanism of phototoxicity of porphyrins, Photochem. Photobiol. 64, 957−962.