ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π³Π»ΡΡΠ°ΠΌΠ°ΡΠ½ΡΡ ΠΈ ΠΠΠΠ-ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π² ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ°Ρ ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π² ΡΡΠ΅Π·Π°Ρ Π³ΠΈΠΏΠΏΠΎΠΊΠ°ΠΌΠΏΠ° ΠΊΡΡΡΡ
Π€Π°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΡΡ ΡΠ°Π·ΡΡΠ΄ΠΎΠ² ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ Π² Π±Π΅Π·-Π?2+ ΡΡΠ΅Π΄Π΅ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΠΠ Π ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π½Π΅ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΡΠΎΠ³ΠΎ ΠΎΠ±ΡΠ·Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π΄Π»Ρ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΡΡΠΈΡ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΡΡ ΡΠ°Π·ΡΡΠ΄ΠΎΠ², ΠΈΡ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΡΡΠΎΠ΄ΡΠΎΠΌΠ½ΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ ΠΈ ΠΏΠ΅ΡΠ΅Ρ ΠΎΠ΄Π° «ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ» Π² «ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠ΅ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΠ΅». ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ Π² Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠΠΠΠ 1. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- 1. 1. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΎΠ³Π΅Π½Π΅Π·Π°
- 1. 2. ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΠΠ
- 1. 3. ΠΠΎΠ·Π±ΡΠΆΠ΄Π°ΡΡΠ°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° Π½Π΅ΠΉΡΠΎΠΏΠ΅ΡΠ΅Π΄Π°ΡΠΈ
- 1. 3. 1. AMPΠ/ΠΊΠ°ΠΈΠ½Π°ΡΠ½ΡΠ΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΡ
- 1. 3. 2. NMDA ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΡ
- 13. 3. ΠΠ΅ΡΠ°Π±ΠΎΡΡΠΎΠΏΠ½ΡΠ΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΡ
- 1. 4. Π’ΠΎΡΠΌΠΎΠ·Π½Π°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° Π½Π΅ΠΉΡΠΎΠΏΠ΅ΡΠ΅Π΄Π°ΡΠΈ
- 1. 4. 1. ΠΠΠΠΠ΄ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΡ
- 1. 4. 3. ΠΠΠΠΡ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΡ
- 1. 5. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ
- 1. 5. 1. ΠΡΠ°ΡΠΊΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½Π°Ρ ΠΏΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΡ
- 1. 5. 2. ΠΠΎΠ»Π³ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½Π°Ρ ΠΏΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΡ
- 1. 5. 3. ΠΠΈΠ½Π΄Π»ΠΈΠ½Π³
ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π³Π»ΡΡΠ°ΠΌΠ°ΡΠ½ΡΡ ΠΈ ΠΠΠΠ-ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π² ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ°Ρ ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π² ΡΡΠ΅Π·Π°Ρ Π³ΠΈΠΏΠΏΠΎΠΊΠ°ΠΌΠΏΠ° ΠΊΡΡΡΡ (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ.
ΠΠΏΠΈΠ»Π΅ΠΏΡΠΈΡ — Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π΅Π²ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅, ΠΊΠΎΡΠΎΡΡΠΌ ΡΡΡΠ°Π΄Π°Π΅Ρ ΠΎΠΊΠΎΠ»ΠΎ 0,5−1% ΡΠ΅Π»ΠΎΠ²Π΅ΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ (Loscher, 2002). Π₯Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΡΡΡΠΊΡΡΡ ΠΌΠΎΠ·Π³Π° ΠΈ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΠΈΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌΠΈ.
Π‘ΠΊΠ»ΠΎΠ½Π½ΠΎΡΡΡ ΠΏΠ°ΡΠΎΠΊΡΠΈΠ·ΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊ Π΅Π΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡΠΌ ΠΈ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΡΠΌ ΡΡΠ»ΠΎΠ²ΠΈΠ΅ΠΌ ΠΏΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΡ Π½Π°ΡΠΈΠ²Π½ΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ ΠΌΠΎΠ·Π³Π° Π² ΡΠΏΠΈΠ»Π΅ΠΏΡΠΎΠ³Π΅Π½Π½ΡΡ. ΠΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ, Π»Π΅ΠΆΠ°ΡΠΈΠ΅ Π² ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΠΈ, ΡΠ²Π»ΡΡΡΡΡ ΠΏΡΠ΅Π΄ΠΌΠ΅ΡΠΎΠΌ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ ΠΈ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π³ΠΎ ΡΡΠΎΠ»Π΅ΡΠΈΡ. ΠΡΠΈ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΌ ΡΠΎΡΡΠ°Π²Π΅ ΠΌΠΎΠ·Π³ΠΎΠ²ΡΡ ΡΡΡΡΠΊΡΡΡ (Bernard et al., 2000; Villineuve et al. 2000), ΡΠΎΡΡΠ°Π²Π΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² (Barbin et al., 1993; Schwarzer et al., 1997), Π²ΠΎΠ·Π±ΡΠ΄ΠΈΠΌΠΎΡΡΠΈ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½ (Ketelaars et al., 2001). Π‘ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ Π±ΠΈΠΎΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ Π±ΠΈΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅, ΡΠΊΠ°Π·ΡΠ²Π°ΡΡΠΈΠ΅ Π½Π° ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΡ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΡ (ΡΠΌ. ΠΎΠ±Π·ΠΎΡΡ Cock. 2002; Kunz, 2002; Khodorov, 2004), ΠΊΠΎΡΠΎΡΠ°Ρ, Π² ΡΠ²ΠΎΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ, Π²Π΅Π΄Π΅Ρ ΠΊ Π‘Π°2+ Π΄ΠΈΠ·ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΠΈ Π³ΠΈΠ±Π΅Π»ΠΈ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ². ΠΡΠΈ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΎΠ³Π΅Π½Π΅Π·Π΅ Π½Π°Π±Π»ΡΠ΄Π°ΡΡΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠ°ΠΊ Π² Π²ΠΎΠ·Π±ΡΠΆΠ΄Π°ΡΡΠ΅ΠΉ Π³Π»ΡΡΠ°ΠΌΠ°ΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ, ΡΠ°ΠΊ ΠΈ ΡΠΎΡΠΌΠΎΠ·Π½ΠΎΠΉ Π ΠΠΠΡΡΠ³ΠΈ ΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠ°Ρ Π½Π΅ΠΉΡΠΎΠΏΠ΅ΡΠ΅Π΄Π°Ρ. ΠΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΈΠ½ΡΠ΅ΡΠΏΡΠ΅ΡΠ°ΡΠΈΡ ΠΏΡΠΈΡΠΎΠ΄Ρ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΠΈ — Π΄ΠΈΡΠ±Π°Π»Π°Π½Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠΈΠΌΠΈ Π½Π΅ΠΉΡΠΎΡΡΠ°Π½ΡΠΌΠΈΡΠ³Π΅ΡΠ½ΡΠΌΠΈ ΡΠΈΡΡΠ΅ΠΌΠ°ΠΌΠΈ.
ΠΠ»Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΡΡΠ΄ΠΎΡΠΎΠΆΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π½Π° ΡΠ΅Π»ΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΈΠ»ΠΈ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π² ΡΡΠ΅Π·Π°Ρ ΠΌΠΎΠ·Π³Π° ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΡΠ΅Π»ΡΠΉ ΡΡΠ΄ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ in vivo ΠΈ in vitro. Π’Π°ΠΊ. Π² ΠΎΠΏΡΡΠ°Ρ Π½Π° ΡΡΠ΅Π·Π°Ρ Π³ΠΈΠΏΠΏΠΎΠΊΠ°ΠΌΠΏΠ°, ΡΠΈΡΠΎΠΊΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΠ΅ΠΉΡΡ ΠΌΠΎΠ΄Π΅Π»ΠΈ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΠΈ in vitro, ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΡΠ΅ ΡΠ°Π·ΡΡΠ΄Ρ (ΠΠ ) ΡΠ°ΡΡΠΎ ΠΈΠ½Π΄ΡΡΠΈΡΡΡΡΡΡ Π»ΠΈΠ±ΠΎ ΠΏΡΡΠ΅ΠΌ ΡΠ΄Π°Π»Π΅Π½ΠΈΡ Mg2* ΠΈΠ· ΠΎΠΌΡΠ²Π°ΡΡΠ΅Π³ΠΎ ΡΡΠ΅Π·Ρ ΠΌΠΎΠ·Π³Π° ΡΠ°ΡΡΠ²ΠΎΡΠ°, Π»ΠΈΠ±ΠΎ Π°ΠΏΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠ΅ΠΉ Π±Π»ΠΎΠΊΠ°ΡΠΎΡΠΎΠ² ΡΠΎΡΠΌΠΎΠ·Π½ΡΡ ΠΠΠΠ-ΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΈΠ½Π°ΠΏΡΠΎΠ², Π±ΠΈΠΊΡΠΊΡΠ»Π»ΠΈΠ½Π° ΠΈ ΠΏΠΈΠΊΡΠΎΡΠΎΠΊΡΠΈΠ½Π° (Π‘ΠΎΠ°ΠΏ and Collingridge, 1985; Mody et al. 1987: Stanton et al. 1987; Schneidermann. 1997; Gorji et al. 2001). ΠΠ°ΡΡΠ΄Ρ Ρ ΡΡΠΈΠΌ, Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΎΠ³Π΅Π½Π½ΡΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠΉ ΡΠ°ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΡΡ: ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ Π²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π*. ΡΠ΄Π°Π»Π΅Π½ΠΈΠ΅ Π½Π°ΡΡΠΆΠ½ΠΎΠ³ΠΎ Π‘Π°2+. Π°ΠΏΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², ΠΏΠΎΠ²ΡΡΠ°ΡΡΠΈΡ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΠΌΠΎΡΡΡ ΠΈΠ»ΠΈ ΡΠ½ΠΈΠΆΠ°ΡΡΠΈΡ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΠ΅ Π² Π½Π΅ΠΉΡΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠΈ (Yaari et al. 1986: Traynelis and Dingledine. 1988; Albrecht and Heinemann. 1989; Tancredi et al. 1997: Semyanov and Godukhin. 2000). Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½ΡΡ ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΎΠ³Π΅Π½Π΅Π·Π°. Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΠΊΠΎΡΠΎΡΠΎΠΉ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΡΡΡ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎ Π½Π°ΡΠ°ΡΡΠ°ΡΡΠ°Ρ ΠΈ ΡΠ°ΠΌΠΎΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°ΡΡΠ°ΡΡΡ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΊΠΈΠ½Π΄Π»ΠΈΠ½Π³ (Goddard 1969; ΠΡΡΠΆΠ°Π½ΠΎΠ²ΡΠΊΠΈΠΉ ΠΈ Π΄Ρ. 1992). ΠΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²ΠΎ Π΄Π°Π½Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² ΡΠΎΠΌ. ΡΡΠΎ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΡ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π΄ΠΎΠ»Π³ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌ Π½Π΅ΠΉΡΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠΆΠ½ΠΎ ΠΈΠ·ΡΡΠ°ΡΡ ΠΏΠΎΡΠ»Π΅ ΠΎΡΠΌΠ΅Π½Ρ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ.
ΠΠ΄Π½Π°ΠΊΠΎ, Π½Π΅ΡΠΌΠΎΡΡΡ Π½Π° Π΄ΠΎΡΡΠΈΠ³Π½ΡΡΡΠ΅ ΡΡΠΏΠ΅Ρ ΠΈ, ΠΌΠ½ΠΎΠ³ΠΈΠ΅ Π²ΠΎΠΏΡΠΎΡΡ, ΠΊΠ°ΡΠ°ΡΡΠΈΠ΅ΡΡ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ ΠΏΠ°ΡΠΎΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΠΈ ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΡΠΌΠΈ ΡΠΈΡΡΠ΅ΠΌΠ°ΠΌΠΈ ΠΏΡΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΠ ΠΈ ΠΈΡ ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ, Π²ΡΠ΅ Π΅ΡΠ΅ Π½Π΅ ΠΏΠΎΠ»ΡΡΠΈΠ»ΠΈ ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ.
ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ Π² Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ Π²Π°ΠΆΠ½ΡΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΎ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΡΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ°Ρ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, ΠΎ ΡΠΎΠ»ΠΈ AMP A, NMDA ΠΈ ΠΠΠΠ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ², ΠΌΠΎΠΆΠ½ΠΎ ΠΏΠΎΠ»ΡΡΠΈΡΡ ΠΏΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΠΈΡΡΡΡΠ΅Π³ΠΎ ΠΈ ΡΠΎΡΠΌΠΎΠ·Π½ΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠΉ ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ Π°ΡΡΠ΅ΡΠ΅Π½ΡΠ½ΡΡ Π²ΠΎΠ»ΠΎΠΊΠΎΠ½ Π½Π° Π²ΡΠ·Π²Π°Π½Π½ΡΠ΅ ΠΠ Π² ΡΡΠ΅Π·Π°Ρ Π³ΠΈΠΏΠΏΠΎΠΊΠ°ΠΌΠΏΠ°.
Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ.
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΡ ΡΠΎΠ»Ρ ΠΈΠΎΠ½ΠΎΡΡΠΎΠΏΠ½ΡΡ Π³Π»ΡΡΠ°ΠΌΠ°ΡΠ½ΡΡ (ΠΠΠ Π-, NMDA-) ΠΈ ΠΠΠΠ-ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ² Π³ΠΈΠΏΠΏΠΎΠΊΠ°ΠΌΠΏΠ° (ΠΏΠΎΠ»Π΅ Π‘Π1) Π² ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ°Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ Π²ΡΠ·Π²Π°Π½Π½ΡΡ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΡΡ ΡΠ°Π·ΡΡΠ΄ΠΎΠ² ΠΏΡΠΈ ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ Π°ΡΡΠ΅ΡΠ΅Π½ΡΠ½ΡΡ Π²ΠΎΠ»ΠΎΠΊΠΎΠ½.
ΠΠ°Π΄Π°ΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ.
Π ΠΎΠΏΡΡΠ°Ρ Π½Π° ΠΏΠ΅ΡΠ΅ΠΆΠΈΠ²Π°ΡΡΠΈΡ ΠΏΠΎΠΏΠ΅ΡΠ΅ΡΠ½ΡΡ ΡΡΠ΅Π·Π°Ρ Π³ΠΈΠΏΠΏΠΎΠΊΠ°ΠΌΠΏΠ° ΠΊΡΡΡΡ ΠΏΠΎΠ»Ρ Π‘Π1 Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ.
1. ΠΡΠΎΠ²Π΅ΡΡΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· Π²ΠΊΠ»Π°Π΄Π° AMP ΠΠΈ NMDA-ΠΏΠΎΠ΄ΡΠΈΠΏΠ° Π³Π»ΡΡΠ°ΠΌΠ°ΡΠ½ΡΡ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Π²ΡΠ·Π²Π°Π½Π½ΡΡ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΎΠ½Π½ΡΡ ΠΎΡΠ²Π΅ΡΠΎΠ² Π² ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ (Π² Mg^-ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅ΠΉ ΡΡΠ΅Π΄Π΅) ΠΏΡΠΈ ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ Π°ΡΡΠ΅ΡΠ΅Π½ΡΠ½ΡΡ Π²ΠΎΠ»ΠΎΠΊΠΎΠ½.
2. ΠΠ·ΡΡΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ Π½Π° ΠΠ , Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΠ΅ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΡΠ΄Π°Π»Π΅Π½ΠΈΡ Π½Π°ΡΡΠΆΠ½ΠΎΠ³ΠΎ Mg2+. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΡ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π°ΠΌΠΏΠ»ΠΈΡΡΠ΄Ρ ΠΈ ΡΠΈΡΠ»Π° ΠΠ‘ Π² ΠΊΠ°ΠΆΠ΄ΠΎΠΌ ΠΠ : Π°) ΠΎΡ ΡΠ°ΡΡΠΎΡΡ ΠΎΡΡΠΎΠ΄ΡΠΎΠΌΠ½ΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈΠ±) ΠΎΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈΠ½ΡΠ΅ΡΠ²Π°Π»ΠΎΠ² ΠΏΠΎΠΊΠΎΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠ°ΡΠΊΠ°ΠΌΠΈ ΡΡΠΈΠΌΡΠ»ΠΎΠ².
3. ΠΡΠΎΠ²Π΅ΡΡΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΠΎΠ»ΠΈ ΠΠΠ Π ΠΈ NMDA ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΡΠ²Π»Π΅Π½ΠΈΠΉ ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΡΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ ΠΈ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΡ ΠΠ Π² Π±Π΅Π·-Mg * ΡΡΠ΅Π΄Π΅.
4. ΠΠ·ΡΡΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ Π½Π° ΠΠ , Π²ΡΠ·Π²Π°Π½Π½ΡΠ΅ Π±Π»ΠΎΠΊΠ°Π΄ΠΎΠΉ ΠΠΠΠΠ΄ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ². ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΡ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΡΡΠΈΡ ΠΠ ΠΏΡΠΈ Π²Π°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ: Π°) ΡΠ°ΡΡΠΎΡΡ ΠΎΡΡΠΎΠ΄ΡΠΎΠΌΠ½ΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈΠ±) Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈΠ½ΡΠ΅ΡΠ²Π°Π»ΠΎΠ² ΠΏΠΎΠΊΠΎΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠ°ΡΠΊΠ°ΠΌΠΈ ΡΡΠΈΠΌΡΠ»ΠΎΠ²Π²) ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΡΡΠ΅Π΄Ρ.
5. ΠΡΠΎΠ²Π΅ΡΡΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· Π²ΠΊΠ»Π°Π΄Π° ΠΠΠ Π ΠΈ NMDA ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠ , Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΠ΅ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ Π±Π»ΠΎΠΊΠ°Π΄Ρ ΡΠΎΡΠΌΠΎΠ·Π½ΡΡ ΠΠΠΠΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΈΠ½Π°ΠΏΡΠΎΠ².
6. ΠΡΠΏΠΎΠ»ΡΠ·ΡΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ½ΡΠ΅ ΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π² Ρ ΠΎΠ΄Π΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΎΠ² Π΄Π°Π½Π½ΡΠ΅, ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΡΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΠ΅ ΡΠ²Π»Π΅Π½ΠΈΡ ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ ΠΈ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΡ Ρ ΡΠΆΠ΅ ΠΈΠ·Π²Π΅ΡΡΠ½ΡΠΌΠΈ ΡΠΎΡΠΌΠ°ΠΌΠΈ ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ ΡΠΈΠ½Π°ΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠΉ.
ΠΠ°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π°.
1. ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΎΠΏΠΈΡΠ°Π½ΠΎ ΡΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ ΠΠ ΠΏΡΠΈ ΠΎΡΡΠΎΠ΄ΡΠΎΠΌΠ½ΠΎΠΉ ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ² Π³ΠΈΠΏΠΏΠΎΠΊΠ°ΠΌΠΏΠ° (ΠΏΠΎΠ»Π΅ CAI) Π² Π±Π΅Π·-Mg2* ΡΡΠ΅Π΄Π΅. ΠΠΎΠΊΠ°Π·Π°Π½Π° Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΡΡΠΎΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ ΠΎΡ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ (ΡΠ°ΡΡΠΎΡΡ ΠΈ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈΠ½ΡΠ΅ΡΠ²Π°Π»ΠΎΠ² ΠΏΠΎΠΊΠΎΡ) Π°ΡΡΠ΅ΡΠ΅Π½ΡΠ½ΡΡ Π²ΠΎΠ»ΠΎΠΊΠΎΠ½.
2. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ°ΡΡΠ΅ΠΉΡΡ ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ Π‘ΠΠ ΠΌΠΎΠΆΠ΅Ρ ΠΏΠ΅ΡΠ΅Ρ ΠΎΠ΄ΠΈΡΡ Π² Π‘ΠΠ’, ΠΊΠΎΡΠΎΡΠΎΠ΅, Π² ΡΠ²ΠΎΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ, ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠΎΠΌ «ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½ΡΡΡΠ΅ΠΉΡΡ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠΈ». ΠΡΠΈ ΠΏΠ΅ΡΠ΅Ρ ΠΎΠ΄Ρ ΠΈΠΌΠ΅ΡΡ ΡΠ°ΡΡΠΎΡΠ½ΠΎ-Π·Π°Π²ΠΈΡΠΈΠΌΡΠΉ Ρ Π°ΡΠ°ΠΊΡΠ΅Ρ.
3. ΠΡΡΠ²Π»Π΅Π½Ρ ΡΠ°Π·Π»ΠΈΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΠ . Π½Π°Π±Π»ΡΠ΄Π°Π΅ΠΌΡΠΌΠΈ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΡΠ΄Π°Π»Π΅Π½ΠΈΡ Π½Π°ΡΡΠΆΠ½ΠΎΠ³ΠΎ Mg2 ΠΈ ΠΠ , Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΠΌΠΈ ΠΏΡΠΈ Π±Π»ΠΎΠΊΠ°Π΄Π΅ ΡΠΎΡΠΌΠΎΠ·Π½ΡΡ ΠΠΠΠΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΈΠ½Π°ΠΏΡΠΎΠ² ΠΏΠΈΠΊΡΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠΌ.
4. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· Π²ΠΊΠ»Π°Π΄Π° NMDA, non-NMDA ΠΈ ΠΠΠΠ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π² ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ ΠΠ Π² Π±Π΅Π·-Mg2* ΡΡΠ΅Π΄Π΅ ΠΈ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ Π±Π»ΠΎΠΊΠ°Π΄Ρ ΠΠΠΠΠ΄ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ².
5. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ ΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄Π²ΡΡ ΡΠΈΠΏΠΎΠ² ΡΠ°ΠΊ Π½Π°Π·ΡΠ²Π°Π΅ΠΌΠΎΠ³ΠΎ NMDA-Π·Π°Π²ΠΈΡΠΈΡΠΌΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ° ΠΠ Π³ΠΈΠΏΠΏΠΎΠΊΠ°ΠΌΠΏΠ°Π»ΡΠ½ΡΡ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ², Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΊΠΎΡΠΎΡΡΡ Π·Π°Π²ΠΈΡΡΡ ΠΎΡ ΡΠΏΠΎΡΠΎΠ±Π° ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ.
ΠΠ°ΡΡΠ½ΠΎ-ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅Π½Π½ΠΎΡΡΡ.
ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π½ΡΠ΅ Π² Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠ΄Ρ ΠΎΠ΄Ρ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ ΠΌΠΎΠ΄Π΅Π»Ρ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΈΠΎΠ½Π½ΡΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΡΡΠ΄ΠΎΡΠΎΠΆΠ½ΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ². ΠΊΠ°ΠΊ Π²Π½ΠΎΠ²Ρ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ , ΡΠ°ΠΊ ΠΈ Π½Π°ΡΠ΅Π΄ΡΠΈΡ ΡΠΈΡΠΎΠΊΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅.
ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° ΡΠΎΡΡΠΎΠΈΡ ΠΈΠ· Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΈ 5 Π³Π»Π°Π². ΠΠ΅ΡΠ²ΡΠΉ ΡΠ°Π·Π΄Π΅Π» ΠΏΠΎΡΠ²ΡΡΠ΅Π½ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ½ΠΎΠΌΡ ΠΎΠ±Π·ΠΎΡΡ. ΠΠΎ Π²ΡΠΎΡΠΎΠΉ Π³Π»Π°Π²Π΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ, ΠΏΡΠΈΠΌΠ΅Π½ΡΠ²ΡΠΈΠ΅ΡΡ Π² ΡΠ°Π±ΠΎΡΠ΅. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π² Ρ ΠΎΠ΄Π΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΎΠ² Π΄Π°Π½Π½ΡΠ΅ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΡ ΠΏΠΎ Ρ ΠΎΠ΄Ρ ΠΈΠ·Π»ΠΎΠΆΠ΅Π½ΠΈΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π½Π΅ΠΊΠΎΡΠΎΡΡΡ Π²ΠΎΠΏΡΠΎΡΠΎΠ² ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ Π² ΡΡΠ΅ΡΡΠ΅ΠΌ ΡΠ°Π·Π΄Π΅Π»Π΅. Π ΡΠ΅ΡΠ²Π΅ΡΡΠΎΠΌ ΡΠ°Π·Π΄Π΅Π»Π΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡΡ ΠΎΠ±ΡΠ΅Π΅ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ². Π‘Π΄Π΅Π»Π°Π½Π½ΡΠ΅ ΠΏΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΡΠ°Π±ΠΎΡΡ Π²ΡΠ²ΠΎΠ΄Ρ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π² ΠΏΡΡΠΎΠΌ ΡΠ°Π·Π΄Π΅Π»Π΅. Π Π°Π±ΠΎΡΠ° Π·Π°Π²Π΅ΡΡΠ°Π΅ΡΡΡ Π±ΠΈΠ±Π»ΠΈΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠΏΠΈΡΠΊΠΎΠΌ, ΡΠΎΡΡΠΎΡΡΠΈΠΌ ΠΈΠ· 194 ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ². ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° ΡΠΎΠ΄Π΅ΡΠΆΠΈΡ 1 ΡΠ°Π±Π»ΠΈΡΡ ΠΈ 38 ΡΠΈΡΡΠ½ΠΊΠΎΠ².
ΠΠΠΠΠ 5. ΠΠ«ΠΠΠΠ«.
1. Π ΠΎΠΏΡΡΠ°Ρ Π½Π° ΡΡΠ΅Π·Π°Ρ Π³ΠΈΠΏΠΏΠΎΠΊΠ°ΠΌΠΏΠ° Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄Π° Π²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΎΡΠ²Π΅Π΄Π΅Π½ΠΈΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠ² ΠΈ ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ ΠΊΠΎΠ»Π»Π°ΡΠ΅ΡΠ°Π»Π΅ΠΉ Π¨Π°ΡΡΠ΅ΡΠ° Π²ΡΡΠ²Π»Π΅Π½ΠΎ 2 Π²ΠΈΠ΄Π° ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΡΡ ΡΠ°Π·ΡΡΠ΄ΠΎΠ², Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΡΠ΄Π°Π»Π΅Π½ΠΈΡ Π½Π°ΡΡΠΆΠ½ΠΎΠ³ΠΎ Π§-2+: «ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠ°Ρ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°ΡΠΈΡ» ΠΈ «ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠ΅ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΠ΅».
2. «Π‘ΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠ°Ρ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°ΡΠΈΡ» Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΡΡΡΠΈΠΌ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΏΠΠΠ‘Π ΠΈ ΡΠΈΡΠ»Π° ΠΠ‘ Π² ΠΊΠ°ΠΆΠ΄ΠΎΠΌ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΠΎΠΌ ΡΠ°Π·ΡΡΠ΄Π΅. «Π‘ΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠ΅ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΠ΅», Π½Π°ΠΏΡΠΎΡΠΈΠ², Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΈΡΠ»Π° ΠΈ Π°ΠΌΠΏΠ»ΠΈΡΡΠ΄Ρ ΠΠ‘ Π² ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΠΎΠΌ ΡΠ°Π·ΡΡΠ΄Π΅, Π½Π΅ΡΠΌΠΎΡΡΡ Π½Π° ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ°ΡΡΠ΅Π΅ΡΡ ΡΠ΄Π»ΠΈΠ½Π΅Π½ΠΈΠ΅ ΠΏΠΠΠ‘Π. ΠΠ±Π° ΡΠ²Π»Π΅Π½ΠΈΡ ΡΠ²Π»ΡΡΡΡΡ ΠΎΠ±ΡΠ°ΡΠΈΠΌΡΠΌΠΈ. ΠΠ΅ΡΠ΅Ρ ΠΎΠ΄ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ Π² ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΠ΅ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°ΡΡΠΎΡΠ½ΠΎ-Π·Π°Π²ΠΈΡΠΈΠΌΡΠΌ. Π£ΡΠΈΠ»Π΅Π½ΠΈΠ΅ ΠΠΠΠΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΡ Π΄ΠΈΠ°Π·Π΅ΠΏΠ°ΠΌΠΎΠΌ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΏΠΎΠ΄Π°Π²Π»ΡΠ΅Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ «ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ» ΠΈ Π΅Π΅ ΠΏΠ΅ΡΠ΅Ρ ΠΎΠ΄ Π² «ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠ΅ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΠ΅».
3. Π‘ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΡΠ΅Π³ΠΈΡΡΡΠ°ΡΠΈΠΈ ΠΏΠΎΠ»Π΅Π²ΡΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠ² ΠΈ Π²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π‘Π°2+ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ, ΡΡΠΎ ΡΠ²Π»Π΅Π½ΠΈΠ΅ «ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠ³ΠΎ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΡ» ΠΌΠΎΠΆΠ½ΠΎ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡ ΠΊΠ°ΠΊ Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊ ΡΠ΅Π½ΠΎΠΌΠ΅Π½Π° «ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½ΡΡΡΠ΅ΠΉΡΡ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠΈ» ΠΈ Π΅Π³ΠΎ ΠΏΠ΅ΡΠ΅Ρ ΠΎΠ΄ Π² «ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½ΡΡΡΡΡΡΡ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΡ» ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°ΡΡΠΎΡΠ½ΠΎ-Π·Π°Π²ΠΈΡΠΈΠΌΡΠΌ.
4. Π€Π°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΡΡ ΡΠ°Π·ΡΡΠ΄ΠΎΠ² ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ Π² Π±Π΅Π·-Π?2+ ΡΡΠ΅Π΄Π΅ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΠΠ Π ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π½Π΅ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΡΠΎΠ³ΠΎ ΠΎΠ±ΡΠ·Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π΄Π»Ρ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΡΡΠΈΡ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΡΡ ΡΠ°Π·ΡΡΠ΄ΠΎΠ², ΠΈΡ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΡΡΠΎΠ΄ΡΠΎΠΌΠ½ΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ ΠΈ ΠΏΠ΅ΡΠ΅Ρ ΠΎΠ΄Π° «ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ» Π² «ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠ΅ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΠ΅».
5. ΠΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΠΠ Π ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡΠΌ ΡΡΠ»ΠΎΠ²ΠΈΠ΅ΠΌ Π΄Π»Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΡΡ ΡΠ°Π·ΡΡΠ΄ΠΎΠ² Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ Π±Π»ΠΎΠΊΠ°Π΄Ρ ΡΠΎΡΠΌΠΎΠ·Π½ΡΡ ΠΠΠΠΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΈΠ½Π°ΠΏΡΠΎΠ² ΠΏΠΈΠΊΡΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠΌ ΠΈΠ»ΠΈ Π±ΠΈΠΊΡΠΊΡΠ»Π»ΠΈΠ½ΠΎΠΌ. ΠΡΠΈ ΡΠ°Π·ΡΡΠ΄Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΏΠΎΠ΄Π°Π²Π»ΡΡΡΡΡ Π±Π»ΠΎΠΊΠ°ΡΠΎΡΠΎΠΌ ΠΠΠ Π ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² (Π‘Π« (ΠΠ₯), Π½ΠΎ ΡΡΡΠΎΠΉΡΠΈΠ²Ρ ΠΊ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΠ Π, Π Π°Π½ΡΠ°Π³ΠΎΠ½ΠΈΡΡΠΎΠ² (ΠΠ-801, ΠΠ Π£).
6. Π‘ΠΎΡΠ΅ΡΠ°Π½Π½Π°Ρ Π±Π»ΠΎΠΊΠ°Π΄Π° ΠΠΠΠ ΠΈ ΠΠΠ Π ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² ΡΠΎΠ·Π΄Π°Π΅Ρ ΡΡΠ»ΠΎΠ²ΠΈΡ, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΡΡ ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΡ ΠΈΠ½Π΄ΡΡΠΈΡΡΠ΅Ρ ΠΠΠΠ-ΠΎΠΏΠΎΡΡΠ΅Π΄ΠΎΠ²Π°Π½Π½ΡΠ΅ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΡΠ΅ ΡΠ°Π·ΡΡΠ΄Ρ Π² Mg" t-coΠ΄epΠΆaΡeΠΉ ΡΡΠ΅Π΄Π΅. ΠΡΠΎΡ Π«ΠΠΠ-ΠΎΠΏΠΎΡΡΠ΅Π΄ΠΎΠ²Π°Π½Π½ΡΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ ΠΏΠΎ ΡΠ²ΠΎΠΈΠΌ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌ ΠΎΡΠ»ΠΈΡΠ°Π΅ΡΡΡ ΠΎΡ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΡΡ ΡΠ°Π·ΡΡΠ΄ΠΎΠ² Π² Π±eΠ·-Mg2,' ΡΡΠ΅Π΄Π΅.
7. Π£Π΄Π°Π»Π΅Π½ΠΈΠ΅ ΠΈΠΎΠ½ΠΎΠ² Mg2+ ΠΈΠ· ΠΏΠΈΠΊΡΠΎΡΠΎΠΊΡΠΈΠ½-ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅Π³ΠΎ ΡΠ°ΡΡΠ²ΠΎΡΠ° ΠΏΠΎΠ΄Π°Π²Π»ΡΠ΅Ρ ΠΠΠ Π-ΠΎΠΏΠΎΡΡΠ΅Π΄ΠΎΠ²Π°Π½Π½ΡΠ΅ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠΎΡΠΌΠ½ΡΠ΅ ΡΠ°Π·ΡΡΠ΄Ρ Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΡΠΈΠΌΡΠ»ΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠ³ΠΎ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΡ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π³ΠΈΠΏΠ΅ΡΡΡΠΈΠΌΡΠ»ΡΡΠΈΠ΅ΠΉ Π«ΠΠΠ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ².
8. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ Π½ΠΎΠ²ΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ ΠΌΠΎΠ΄Π΅Π»Ρ Π΄Π»Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΡΡΠ΄ΠΎΡΠΎΠΆΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ. Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΡΡΠ° ΠΌΠΎΠ΄Π΅Π»Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π° Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΎΠ² ΡΠ»Π΅Π΄ΡΡΡΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ: ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² Π«Π-ΡΠΈΠ½ΡΠ°Π·Ρ (Π¬-Π«ΠΠΠ), ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π°Π³Π΅Π½ΡΠΎΠ², ΡΡΠΈΠ»ΠΈΠ²Π°ΡΡΠΈΡ ΠΠΠΠ-ΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΠ΅ (Π΄ΠΈΠ°Π·Π΅ΠΏΠ°ΠΌ), ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΡΡΠ΄ΠΎΡΠΎΠΆΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ (Π»Π°ΠΌΠΎΡΡΠΈΠ΄ΠΆΠΈΠ½, ΠΊΠ°ΡΠ±Π°ΠΌΠ°Π·Π΅ΠΏΠΈΠ½, Π±Π°ΠΊΠ»ΠΎΡΠ΅Π½ ΠΈ Π΄Ρ.).
ΠΠΠΠΠΠΠΠ ΠΠΠ‘Π’Π.
ΠΠ²ΡΠΎΡ Π²ΡΡΠ°ΠΆΠ°Π΅Ρ Π³Π»ΡΠ±ΠΎΠΊΡΡ ΠΏΡΠΈΠ·Π½Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΈ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΡΡ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ½ΠΎΡΡΡ ΡΠ²ΠΎΠ΅ΠΌΡ Π½Π°ΡΡΠ½ΠΎΠΌΡ ΡΡΠΊΠΎΠ²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ ΠΏΡΠΎΡΠ΅ΡΡΠΎΡΡ, Π΄ΠΎΠΊΡΠΎΡΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ Π½Π°ΡΠΊ, Π·Π°ΡΠ»ΡΠΆΠ΅Π½Π½ΠΎΠΌΡ Π΄Π΅ΡΡΠ΅Π»Ρ Π½Π°ΡΠΊΠΈ Π Π€ ΠΠΎΡΠΈΡΡ ΠΠ·ΡΠ°ΠΈΠ»Π΅Π²ΠΈΡΡ Π₯ΠΎΠ΄ΠΎΡΠΎΠ²Ρ, Π±Π΅Π· ΡΡΠΊΠΎΠ²ΠΎΠ΄ΡΡΠ²Π° ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΎ Π±Ρ Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ.
Π₯ΠΎΡΡ ΠΈΡΠΊΡΠ΅Π½Π½Π΅ ΠΏΠΎΠ±Π»Π°Π³ΠΎΠ΄Π°ΡΠΈΡΡ ΡΡΠ°ΡΡΠ΅Π³ΠΎ Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠ° ΠΠ»Π°Π΄ΠΈΠΌΠΈΡΠ° ΠΠ΅ΠΎΡΠ³ΠΈΠ΅Π²ΠΈΡΠ° ΠΠΎΡΠΈΠ½Π° Π·Π° ΠΏΠΎΠΌΠΎΡΡ ΠΊΠ°ΠΊ Π² ΠΎΡΠ²ΠΎΠ΅Π½ΠΈΠΈ Π°Π²ΡΠΎΡΠΎΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ Π²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΡΠ΅Π³ΠΈΡΡΡΠ°ΡΠΈΠΈ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ² Π³ΠΈΠΏΠΏΠΎΠΊΠ°ΠΌΠΏΠ°, ΡΠ°ΠΊ ΠΈ Π² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΎΠ².
ΠΡΠ΄Π΅Π»ΡΠ½Π°Ρ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ½ΠΎΡΡΡ Π‘Π΅ΡΠ³Π΅Ρ ΠΠ΅Π½Π½Π°Π΄ΡΠ΅Π²ΠΈΡΡ ΠΠΎΡΠ΅Π»Π΅Π²Ρ Π·Π° ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΡ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΡΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌ.
Π₯ΠΎΡΠ΅Π»ΠΎΡΡ Π±Ρ ΠΏΠΎΠ±Π»Π°Π³ΠΎΠ΄Π°ΡΠΈΡΡ Π²ΡΠ΅Ρ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠΎΠ² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° ΠΈ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΡΠΈΠ³Π½Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΠΠΠΠΠ Π ΠΠΠ Π·Π° ΡΠ΅ΠΏΠ»ΡΡ Π΄ΡΡΠΆΠ΅ΡΠΊΡΡ Π°ΡΠΌΠΎΡΡΠ΅ΡΡ Π² ΠΊΠΎΠ»Π»Π΅ΠΊΡΠΈΠ²Π΅.
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- ΠΠ°ΡΠΊΠ°ΡΠΎΠ²Π° Π. Π. ΠΠΈΠΊΠΎΡΠ½ Π.Π., ΠΠΎΡΠ°ΡΠ΅Π²Π° Π.Π‘, ΠΡΠ±ΡΠΈΠ½Π° JI. H, ΠΠ°Π½ΠΈΠ½ Π. Π€, Π Π°Π΅Π²ΡΠΊΠΈΠΉ Π. Π‘. ΠΡΡΠΌΠΎΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΎΠΊΡΠΈΠ΄Π° Π°Π·ΠΎΡΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΠΠ Π² ΠΌΠΎΠ·Π³Π΅ ΠΊΡΡΡΡ ΠΏΡΠΈ ΡΡΠ΄ΠΎΡΠΎΠ³Π°Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΠΏΡΠΈΡΠΎΠ΄Ρ. // ΠΠΠ. 1996. — Π’. 348.-Π‘. 119−121.
- ΠΠΈΠ½ΠΎΠ³ΡΠ°Π΄ΠΎΠ²Π° Π.Π‘. ΠΠΈΠΏΠΏΠΎΠΊΠ°ΠΌΠΏ ΠΈ ΠΏΠ°ΠΌΡΡΡ. // Π: ΠΠ°ΡΠΊΠ°. 1975.
- ΠΡΡΠΆΠ°Π½ΠΎΠ²ΡΠΊΠΈΠΉ Π. Π., Π¨Π°Π½Π΄ΡΠ° Π.Π, ΠΠ°Π·Π°ΡΠ°ΡΠΈ A.M., ΠΠΎΠ»ΠΎΡ ΠΎΠ²Π° Π. Π. Π ΠΎΠ»Ρ Π»ΠΈΠΌΠ±ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΡΡΠΊΡΡΡ Π² ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ°Ρ ΠΏΠΎΡΡ-ΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΠΈ. // ΠΡΠ». ΡΠΊΡΠΏΠ΅ΡΠΈΠΌ Π±ΠΈΠΎΠ» ΠΈ ΠΌΠ΅Π΄. 1992. — Π’. 113. — № 3. — Π‘. 241−245.
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