Π Π°Π·Π²ΠΈΡΠΈΠ΅ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΏΡΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΎΠ±ΡΡΠ΅Π½Π½ΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠΈ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ Π»ΠΈΠ½ΠΈΠΉ C57BL/6J ΠΈ CBA/LAC: ΡΡΡΠ΅ΠΊΡΡ Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΠΊΠΎΠ²
Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ Π² ΡΡΡΡΠΊΡΡΡΠ΅ Π²ΡΠ°ΠΆΠ΄Π΅Π±Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ ΠΎΠ±Π΅ΠΈΡ Π»ΠΈΠ½ΠΈΠΉ ΠΏΡΠΎΠΈΡΡ ΠΎΠ΄ΡΡ ΡΡ ΠΎΠ΄Π½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ: Ρ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΡΡ ΡΠ°ΠΌΡΠΎΠ² Ρ ΠΎΠΏΡΡΠΎΠΌ 2-Ρ ΠΊΠΎΠ½ΡΡΠΎΠ½ΡΠ°ΡΠΈΠΈ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°ΡΡ ΠΏΡΡΠΌΡΠ΅ Π°ΡΠ°ΠΊΠΈ Π½Π° ΠΏΡΠΎΡΠΈΠ²Π½ΠΈΠΊΠ°, Π² ΡΠΎ Π²ΡΠ΅ΠΌΡ ΠΊΠ°ΠΊ ΡΠ°ΠΌΡΡ Ρ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΌ ΠΎΠΏΡΡΠΎΠΌ Π°Π³ΡΠ΅ΡΡΠΈΠΈ (20 Π΄Π½Π΅ΠΉ) ΡΠ°ΡΡΠΎ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΡΡ ΡΠΈΡΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈΠ»ΠΈ Π½Π΅ΠΏΡΡΠΌΡΠ΅ ΡΠΎΡΠΌΡ Π°Π³ΡΠ΅ΡΡΠΈΠΈ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½ΠΎΠ΅ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΠΌ Π°Π½Π°Π»ΠΈΠ·ΠΎΠΌ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠΠΠΠ 1. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«: «ΠΠΠΠ ΠΠ₯ΠΠΠΠ§ΠΠ‘ΠΠΠ ΠΠΠ₯ΠΠΠΠΠΠ« ΠΠΠ ΠΠ‘Π‘ΠΠΠΠΠΠ ΠΠΠΠΠΠΠΠΠ―: Π‘ΠΠΠ ΠΠΠΠΠΠΠ Π‘ΠΠ‘Π’ΠΠ―ΠΠΠ ΠΠ ΠΠΠΠΠΠ«»
- 1. 1. ΠΠΈΠ΄Ρ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
- 1. 2. ΠΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
- 1. 2. 1. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π°Π³ΡΠ΅ΡΡΠΈΠΈ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
- 1. 2. 2. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π°Π³ΡΠ΅ΡΡΠΈΠΈ Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
- 1. 3. ΠΠ΅ΠΉΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΏΠΎΡΠΎΠ±Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ
- 1. 3. 1. Π ΠΎΠ»Ρ ΡΠ΅ΡΠΎΡΠΎΠ½Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΌΠΎΠ·Π³Π° Π² ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΈ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ
- 1. 3. 1. 1. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 1. 3. 1. Π ΠΎΠ»Ρ ΡΠ΅ΡΠΎΡΠΎΠ½Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΌΠΎΠ·Π³Π° Π² ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΈ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ
- 1. 3. 1. 3. ΠΠΎΡΡΠ΅ΠΊΡΠΈΡ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½ΠΎΠ²ΡΠΌΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌΠΈ
- 1. 3. 2. Π ΠΎΠ»Ρ Π΄ΠΎΡΠ°ΠΌΠΈΠ½Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΈΡΡΠ΅ΠΌ ΠΌΠΎΠ·Π³Π° Π² ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΈ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ
- 1. 3. 2. 1. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 1. 3. 2. 2. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π½Π° Π»ΡΠ΄ΡΡ
- 1. 3. 2. 3. ΠΠΎΡΡΠ΅ΠΊΡΠΈΡ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π½Π΅ΠΉΡΠΎΠ»Π΅ΠΏΡΠΈΠΊΠ°ΠΌΠΈ
- 1. 3. 3. Π ΠΎΠ»Ρ ΠΠΠΠ-Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΌΠΎΠ·Π³Π° Π² ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΈ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ
- 1. 3. 4. Π ΠΎΠ»Ρ ΠΎΠΏΠΈΠΎΠΈΠ΄Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΈΡΡΠ΅ΠΌ ΠΌΠΎΠ·Π³Π° Π² ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΈ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ
- 2. 1. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΆΠΈΠ²ΠΎΡΠ½ΡΠ΅
- 2. 3. 1. Π’Π΅ΡΡ «ΠΏΠ΅ΡΠ΅Π³ΠΎΡΠΎΠ΄ΠΊΠ°»
- 2. 3. 2. Π’Π΅ΡΡ «ΠΏΡΠΈΠΏΠΎΠ΄Π½ΡΡΡΠΉ ΠΊΡΠ΅ΡΡΠΎΠΎΠ±ΡΠ°Π·Π½ΡΠΉ Π»Π°Π±ΠΈΡΠΈΠ½Ρ»
- 2. 3. 3. ΠΠ³ΠΎΠ½ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ
- 3. 1. 1. ΠΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ Π΄Π²ΡΡ Π»ΠΈΠ½ΠΈΠΉ Π½Π° ΡΠ°Π·Π½ΡΡ ΡΡΠ°ΠΏΠ°Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠΈΠΏΠ° ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ
- 3. 1. 2. ΠΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² Π°Π³ΠΎΠ½ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌ ΠΎΠΏΡΡΠΎΠΌ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΡΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΉ
- 3. 1. 4. ΠΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ²
- 3. 2. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ Π½Π° ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ Π»ΠΈΠ½ΠΈΠΉ Π‘57 ΠΈ Π‘ΠΠ Ρ ΡΠ°Π·Π½ΡΠΌ ΠΎΠΏΡΡΠΎΠΌ Π°Π³ΡΠ΅ΡΡΠΈΠΈ
- 3. 2. 1. ΠΠΈΠ½ΠΈΡ Π‘
- 3. 2. 2. ΠΠΈΠ½ΠΈΡ Π‘ΠΠ
- 3. 2. 3. ΠΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ²
- 3. 3. ΠΡΡΠ΅ΠΊΡΡ Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΠΊΠΎΠ² Π½Π° Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡ ΠΎΡΠΎΠ±Π΅ΠΉ
- 3. 3. 1. ΠΡΡΠ΅ΠΊΡΡ Π±ΡΡΠΏΠΈΡΠΎΠ½Π°
- 3. 3. 2. ΠΡΡΠ΅ΠΊΡΡ Π΄ΠΈΠ°Π·Π΅ΠΏΠ°ΠΌΠ°
- 3. 3. 3. ΠΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ²
- 3. 4. ΠΠ±ΡΠ°Ρ Π΄ΠΈΡΠΊΡΡΡΠΈΡ
Π Π°Π·Π²ΠΈΡΠΈΠ΅ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΏΡΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΎΠ±ΡΡΠ΅Π½Π½ΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠΈ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ Π»ΠΈΠ½ΠΈΠΉ C57BL/6J ΠΈ CBA/LAC: ΡΡΡΠ΅ΠΊΡΡ Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΠΊΠΎΠ² (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ. ΠΠ³ΡΠ΅ΡΡΠΈΡ — ΡΡΠΎ Π»ΡΠ±Π°Ρ ΡΠΎΡΠΌΠ° ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ, Π½Π°ΡΠ΅Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π½Π° ΠΎΡΠΊΠΎΡΠ±Π»Π΅Π½ΠΈΠ΅ ΠΈΠ»ΠΈ ΠΏΡΠΈΡΠΈΠ½Π΅Π½ΠΈΠ΅ Π²ΡΠ΅Π΄Π° Π΄ΡΡΠ³ΠΎΠΌΡ ΠΆΠΈΠ²ΠΎΠΌΡ ΡΡΡΠ΅ΡΡΠ²Ρ [ΠΡΡΠΎΠ½, Π ΠΈΡΠ°ΡΠ΄ΡΠΎΠ½, 1999]. Π ΠΏΡΠΈΡΠΎΠ΄Π½ΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠ°ΡΠΈΡ ΡΠΈΠ»ΡΠ½ΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠΈ Π²ΡΡΡΠ΅ΡΠ°Π΅ΡΡΡ ΡΠ΅Π΄ΠΊΠΎ Π² ΡΠΈΠ»Ρ ΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π° ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ², ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΡΡΠΈΡ Π΅Π΅ ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ [ΠΠ΅Π½Π½ΠΈΠ½Π³, 1982]. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌ ΠΈΠ· ΡΠ°ΠΊΠΈΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈΠ΅ΡΠ°ΡΡ ΠΈΠΈ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΠΏΡΠΈ ΡΠ»ΠΎΠΆΠΈΠ²ΡΠΈΡ ΡΡ Π΄ΠΎΠΌΠΈΠ½Π°Π½ΡΠ½ΠΎ-ΡΡΠ±ΠΎΡΠ΄ΠΈΠ½Π°Π½ΡΠ½ΡΡ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡΡ ΡΡΠ±ΠΎΡΠ΄ΠΈΠ½Π°Π½ΡΠ½ΡΠ΅ ΡΠ°ΠΌΡΡ Π½Π΅ Π²ΡΡΡΠΏΠ°ΡΡ Π² Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΡΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ, ΠΈΠ·Π±Π΅Π³Π°Ρ ΠΊΠΎΠ½ΡΠ»ΠΈΠΊΡΠ½ΡΡ ΡΠΈΡΡΠ°ΡΠΈΠΉ.
Π ΡΠ΅Π»ΠΎΠ²Π΅ΡΠ΅ΡΠΊΠΎΠΌ ΠΎΠ±ΡΠ΅ΡΡΠ²Π΅ ΡΠ°ΡΡΠΎ ΡΠΎΡΠΌΠΈΡΡΡΡΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡ, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΡΠ΅Π±ΡΡΡ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΠΈ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ, Π½Π°ΠΏΡΠΈΠΌΠ΅Ρ, ΠΏΡΠΈ ΡΡΠ°ΡΡΠΈΠΈ Π² Π²ΠΎΠ΅Π½Π½ΡΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡΡ , Π² ΡΠ»ΡΠΆΠ±Π°Ρ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ, ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΌ ΡΠΏΠΎΡΡΠ΅ (Ρ ΠΎΠΊΠΊΠ΅ΠΉ, Π±ΠΎΠΊΡ ΠΈ Ρ. Π΄.). Π’Π°ΠΊΠΎΠΉ Π²ΠΈΠ΄ Π°Π³ΡΠ΅ΡΡΠΈΠΈ Ρ Π»ΡΠ΄Π΅ΠΉ ΠΎΡΠ½ΠΎΡΠΈΡΡΡ ΠΊ ΡΠ°ΠΊ Π½Π°Π·ΡΠ²Π°Π΅ΠΌΠΎΠΉ ΠΎΠ±ΡΡΠ΅Π½Π½ΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠΈ (learned aggression) [Barratt, 1994], ΠΊΠΎΡΠΎΡΠ°Ρ Π² ΠΏΡΠΈΡΠΎΠ΄Π΅ Π½Π΅ Π²ΡΡΡΠ΅ΡΠ°Π΅ΡΡΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠΉ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ Π½Π° ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΎΡΠ»ΠΎΠΆΠ½ΡΡΡΡΡ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ΠΌ Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½ΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ΠΎΠ². ΠΠΎΠ΄Π΅Π»Ρ ΡΠ΅Π½ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΠ°ΠΊΡΠ°, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½Π°Ρ Ρ ΠΠ½ΡΡΠΈΡΡΡΠ΅ Π¦ΠΈΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΠ΅Π½Π΅ΡΠΈΠΊΠΈ Π‘Π Π ΠΠ [Kudryavtseva, 1991], ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΠΎΠ»ΡΡΠ°ΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ Ρ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΌ ΠΎΠΏΡΡΠΎΠΌ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠ΅Π³ΠΎΡΡ ΠΏΠΎΠ±Π΅Π΄Π°ΠΌΠΈ Π² Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΡΡ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΡ ΠΊΠΎΠ½ΡΡΠΎΠ½ΡΠ°ΡΠΈΡΡ . Π‘ΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΡΠ°ΠΊΠΈΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΈ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Ρ Π½ΠΈΡ ΠΎΠ±ΡΡΠ΅Π½Π½ΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠΈ.
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΈ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· Π°ΡΠΏΠ΅ΠΊΡΠΎΠ², ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΠΌΡΡ ΠΏΡΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ Π°Π³ΡΠ΅ΡΡΠΈΠΈ Ρ Π»ΡΠ΄Π΅ΠΉ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΈ ΠΎΠ±ΡΡΠ΅Π½Π½ΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ [Barratt, 1959, 1965, 1972], ΡΡΠΎ Ρ Π»ΡΠ΄Π΅ΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΡΠ²ΡΠ·Π°Π½Ρ ΠΎΡΡΠΎΠ³ΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡΡ: Π΅ΡΡΡ ΡΡΠ±ΡΠ΅ΠΊΡΡ Ρ Π²ΡΡΠΎΠΊΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΈ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡΡ, Ρ Π²ΡΡΠΎΠΊΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΈ Π½ΠΈΠ·ΠΊΠΎΠΉ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡΡ, Ρ Π½ΠΈΠ·ΠΊΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΈ Π½ΠΈΠ·ΠΊΠΎΠΉ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡΡ ΠΈ, Π½Π°ΠΊΠΎΠ½Π΅Ρ, Ρ Π½ΠΈΠ·ΠΊΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΈ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π½Π° ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ [Guillot,.
Chapouthier, 1996; Avgustinovich et al., 1997; Clement, Chapouthier, 1998; Ferrari et al., 1998; Parmigiani et al., 1999; Haller, Halasz, 2000] ΡΠ°ΠΊΠΆΠ΅ Π²ΡΡΠ²ΠΈΠ»ΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ Π²Π°ΡΠΈΠ°Π½ΡΡ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΡ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ, Π½ΠΎ ΡΠ΅ΡΠΊΡΡ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΡ ΠΏΡΠΎΡΠ»Π΅Π΄ΠΈΡΡ ΠΏΠΎΠΊΠ° Π½Π΅ ΡΠ΄Π°Π»ΠΎΡΡ, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ, Π² ΡΠΈΠ»Ρ ΡΠΎΠ³ΠΎ, ΡΡΠΎ Π² ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Ρ Π½Π΅ ΡΡΠΈΡΡΠ²Π°Π»ΠΈΡΡ Π²ΡΠ΅ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΠ΅ ΠΏΡΠΈΡ ΠΎΡΠΌΠΎΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΎΡΠΎΠ±Π΅ΠΉ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠΌ, ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ ΡΡΠ»ΠΎΠ²ΠΈΡΠΌΠΈ ΠΈ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³ΡΡ Π²Π»ΠΈΡΡΡ Π½Π° ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΊΠ°ΠΊ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ , ΡΠ°ΠΊ ΠΈ Π½Π° ΠΈΡ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡ.
Π¦Π΅Π»Ρ ΠΈ Π·Π°Π΄Π°ΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
ΠΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΡΠ΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠ³ΠΎ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±ΡΡΠ΅Π½Π½ΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠΈ ΠΏΠΎΠ΄ Π²Π»ΠΈΡΠ½ΠΈΠ΅ΠΌ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° ΠΏΠΎΠ±Π΅Π΄ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ Π»ΠΈΠ½ΠΈΠΉ C57BL/6J ΠΈ Π‘ΠA/Lac Ρ ΠΈΡΡ ΠΎΠ΄Π½ΠΎ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ ΠΏΡΠΈΡ ΠΎΡΠΌΠΎΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ ΠΈ ΡΠ°Π·Π½ΡΠΌ ΡΡΠΎΠ²Π½Π΅ΠΌ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ Π² Ρ ΠΎΠ΄Π΅ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ Π±ΡΠ»ΠΈ ΠΏΠΎΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ Π·Π°Π΄Π°ΡΠΈ:
1. ΠΡΡΠ²ΠΈΡΡ Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΠΎ-ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠΈΠΏΠ° ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠ΅Π³ΠΎΡΡ ΠΏΠΎΠ±Π΅Π΄Π°ΠΌΠΈ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ Π»ΠΈΠ½ΠΈΠΉ C57BL/6J ΠΈ CBA/Lac;
2. ΠΡΡΠ²ΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° ΡΠ°Π·Π½ΠΎΠΉ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π½Π° ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ ΡΠ°Π·Π½ΡΡ Π»ΠΈΠ½ΠΈΠΉ;
3. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΡ ΡΡΡΠ΅ΠΊΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΠΊΠΎΠ² (Π±ΡΡΠΏΠΈΡΠΎΠ½, Π΄ΠΈΠ°Π·Π΅ΠΏΠ°ΠΌ) Π½Π° ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡ ΠΈ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ Ρ ΡΠ°Π·Π½ΡΠΌ ΠΎΠΏΡΡΠΎΠΌ Π°Π³ΡΠ΅ΡΡΠΈΠΈ.
ΠΠ°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π°. ΠΠΏΠ΅ΡΠ²ΡΠ΅ Π² ΡΠ°Π±ΠΎΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ ΠΏΠΎΠ΄ Π²Π»ΠΈΡΠ½ΠΈΠ΅ΠΌ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° ΠΏΠΎΠ±Π΅Π΄ Π² Π°Π³ΠΎΠ½ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡΡ ΡΠΎΡΠΌΠΈΡΡΠ΅ΡΡΡ ΡΡΡΠΎΠΉΡΠΈΠ²Π°Ρ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½Π°Ρ ΠΌΠΎΡΠΈΠ²Π°ΡΠΈΡ ΠΈ ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΡΡΡ ΠΎΠ±ΡΡΠ΅Π½Π½Π°Ρ Π°Π³ΡΠ΅ΡΡΠΈΡ, ΠΊΠΎΡΠΎΡΠ°Ρ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ Π½ΠΎΠ²ΡΡ ΡΠΎΡΠΌ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ, ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡΠΈΡ ΠΎΠ± ΠΎΠ±ΡΡΠ΅Π½ΠΈΠΈ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΡΠ°ΡΠ΅Π³ΠΈΠΈ ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ²Π½ΠΈΠΊΠ°.
ΠΠΏΠ΅ΡΠ²ΡΠ΅ Π±ΡΠ»ΠΎ Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±ΡΡΠ΅Π½Π½ΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠΈ ΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈ Π΅Π΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΡ Π·Π°Π²ΠΈΡΡΡ ΠΎΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° ΠΈ Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΠΎ-ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ² ΠΎΡΠΎΠ±ΠΈ (Π»ΠΈΠ½ΠΈΠΈ ΠΌΡΡΠ΅ΠΉ).
ΠΠΏΠ΅ΡΠ²ΡΠ΅ Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΠΊΠΎΠ² (Π±ΡΡΠΏΠΈΡΠΎΠ½Π° ΠΈ Π΄ΠΈΠ°Π·Π΅ΠΏΠ°ΠΌΠ°) ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΡΠ΅ΡΡΡ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ. Π’Π°ΠΊ, Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ Ρ Π½Π΅Π±ΠΎΠ»ΡΡΠΈΠΌ ΠΎΠΏΡΡΠΎΠΌ Π°Π³ΡΠ΅ΡΡΠΈΠΈ Π±ΡΡΠΏΠΈΡΠΎΠ½ ΠΈ Π΄ΠΈΠ°Π·Π΅ΠΏΠ°ΠΌ ΠΎΠΊΠ°Π·ΡΠ²Π°Π»ΠΈ Π°Π½ΠΊΡΠΈΠΎΠ³Π΅Π½Π½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅, ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎ ΡΠ½ΠΈΠΆΠ°Ρ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅, ΡΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ Ρ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΌ ΠΎΠΏΡΡΠΎΠΌ Π°Π³ΡΠ΅ΡΡΠΈΠΈ Π΄ΠΈΠ°Π·Π΅ΠΏΠ°ΠΌ ΠΎΠΊΠ°Π·ΡΠ²Π°Π» Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ Π½Π°ΡΡΠ΄Ρ Ρ Π°Π½ΡΠΈΠ°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΡΠΌ, Π° Π±ΡΡΠΏΠΈΡΠΎΠ½ Π½Π΅ ΠΎΠΊΠ°Π·ΡΠ²Π°Π» Π½ΠΈΠΊΠ°ΠΊΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ Π½ΠΈ Π½Π° ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡ, Π½ΠΈ Π½Π° Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΡ.
Π’Π΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΏΡΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½ΡΡ ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΠΈ Ρ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΠΎΠ², ΠΏΡΠΎΡΠ²Π»ΡΠ²ΡΠΈΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²ΡΠ΅ΠΌΡ Π°Π³ΡΠ΅ΡΡΠΈΡ, ΠΈ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ Π°ΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΡΡ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡ Π²ΡΡΡΡΠΏΠ°Π΅Ρ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΡΠΎΠ²ΠΎΡΠΈΡΡΡΡΠ΅Π³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ°.
ΠΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ, Π²ΡΠ½ΠΎΡΠΈΠΌΡΠ΅ Π½Π° Π·Π°ΡΠΈΡΡ:
1. ΠΠΎΠ²ΡΠΎΡΠ½ΡΠΉ ΠΎΠΏΡΡ Π°Π³ΡΠ΅ΡΡΠΈΠΈ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠΈΠΉΡΡ ΠΏΠΎΠ±Π΅Π΄Π°ΠΌΠΈ Π² Π°Π³ΠΎΠ½ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡΡ , ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±ΡΡΠ΅Π½Π½ΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠΈ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ Π»ΠΈΠ½ΠΈΠΉ Π‘57ΠΠ¬/61 ΠΈ Π‘ΠΠ/Π¬Π°Ρ;
2. ΠΠΎΠ΄ Π²Π»ΠΈΡΠ½ΠΈΠ΅ΠΌ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ Π΄Π°Π½Π½ΡΡ Π»ΠΈΠ½ΠΈΠΉ ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΡΡΡ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡ, Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ ΠΊΠΎΡΠΎΡΠΎΠΉ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° ΠΈ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° ΠΌΡΡΠ΅ΠΉ;
3. ΠΠΎΠ²ΡΠΎΡΠ½ΡΠΉ ΠΎΠΏΡΡ Π°Π³ΡΠ΅ΡΡΠΈΠΈ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΡΠ΅Ρ ΡΡΡΠ΅ΠΊΡΡ Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΠΊΠΎΠ² Π΄ΠΈΠ°Π·Π΅ΠΏΠ°ΠΌΠ° ΠΈ Π±ΡΡΠΏΠΈΡΠΎΠ½Π°. Π Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΠΊΠΈ ΠΌΠΎΠ³ΡΡ ΡΠ½ΠΈΠΆΠ°ΡΡ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΡ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ, ΠΎΠΊΠ°Π·ΡΠ²Π°Ρ Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈΠ»ΠΈ Π°Π½ΠΊΡΠΈΠΎΠ³Π΅Π½Π½ΡΠΉ ΡΡΡΠ΅ΠΊΡΡ.
ΠΠΏΡΠΎΠ±Π°ΡΠΈΡ ΡΠ°Π±ΠΎΡΡ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΈ Π΄ΠΎΠ»ΠΎΠΆΠ΅Π½Ρ Π°Π²ΡΠΎΡΠΎΠΌ Π½Π° 14-ΠΌ ΡΡΠ΅Π·Π΄Π΅ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ΅ΡΡΠ²Π° ΠΏΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π°Π³ΡΠ΅ΡΡΠΈΠΈ (1Π11Π) (ΠΠ°Π»Π΅Π½ΡΠΈΡ, ΠΡΠΏΠ°Π½ΠΈΡ, 2000 Π³.), Π½Π° 7-ΠΉ ΠΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠΉ Π»Π΅ΡΠ½Π΅ΠΉ ΡΠΊΠΎΠ»Π΅ ΠΏΠΎ ΠΠ΅ΠΉΡΠΎΠ³Π΅Π½Π΅ΡΠΈΠΊΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ (Π‘ΡΠΎΠΊΠ³ΠΎΠ»ΡΠΌ, Π¨Π²Π΅ΡΠΈΡ, 2001 Π³.), Π½Π° 4-ΠΌ Π‘ΡΠ΅Π·Π΄Π΅ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΎΠ² Π‘ΠΈΠ±ΠΈΡΠΈ (ΠΠΎΠ²ΠΎΡΠΈΠ±ΠΈΡΡΠΊ, 2002 Π³.), Π½Π° 8-ΠΉ Π Π΅Π³ΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΠΈ ΠΠ²ΡΠΎΠΏΠ΅ΠΉΡΠΊΠΎΠΉ ΠΠΎΠ»Π»Π΅Π³ΠΈΠΈ ΠΏΠΎ.
ΠΠ΅ΠΉΡΠΎΠΏΡΠΈΡ ΠΎΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ (ΠΠ‘β) (ΠΠΎΡΠΊΠ²Π°, 2005 Π³.). ΠΡΠΎΠΌΠ΅ ΡΡΠΎΠ³ΠΎ, ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΡΠ»ΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ Π½Π° 22 ΡΡΠ΅Π·Π΄Π΅ Π‘Π¨Π (ΠΡΡΡΡΠ΅Π»Ρ, ΠΠ΅Π»ΡΠ³ΠΈΡ, 2000 Π³.) ΠΈ Π½Π° ΠΠ΅ΡΠ²ΠΎΠΌ ΠΎΠ±ΡΠ΅Π΄ΠΈΠ½Π΅Π½Π½ΠΎΠΌ ΡΡΠ΅Π·Π΄Π΅ ΠΠΠ Π (ΠΠ°ΡΡΠ΅Π»Ρ, Π€ΡΠ°Π½ΡΠΈΡ, 2001 Π³.).
ΠΠΎ ΡΠ΅ΠΌΠ΅ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ ΠΎΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½ΠΎ 17 ΡΠ°Π±ΠΎΡ, ΠΈΠ· Π½ΠΈΡ 11 ΡΡΠ°ΡΠ΅ΠΉ.
ΠΠ«ΠΠΠΠ«.
1. ΠΠΎΠ²ΡΠΎΡΠ½ΡΠΉ ΠΎΠΏΡΡ Π°Π³ΡΠ΅ΡΡΠΈΠΈ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠΈΠΉΡΡ ΠΏΠΎΠ±Π΅Π΄Π°ΠΌΠΈ Π² Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΡΡ ΠΌΠ΅ΠΆΡΠ°ΠΌΡΠΎΠ²ΡΡ ΠΊΠΎΠ½ΡΡΠΎΠ½ΡΠ°ΡΠΈΡΡ , ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠΈΠΏΠ° ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ ΡΠ°Π·Π½ΡΡ Π»ΠΈΠ½ΠΈΠΉ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ Π³Π΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΡ Π² ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΡ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ: Ρ ΡΠ°ΠΌΡΠΎΠ² Π»ΠΈΠ½ΠΈΠΈ Π‘ΠΠ/Π¬Π°Ρ ΠΎΠ±ΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π²ΡΠ°ΠΆΠ΄Π΅Π±Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π½Π΅ ΠΈΠ·ΠΌΠ΅Π½ΡΠ΅ΡΡΡ ΠΎΡ ΡΠ΅ΡΡΠ° ΠΊ ΡΠ΅ΡΡΡ, ΡΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ Ρ ΡΠ°ΠΌΡΠΎΠ² Π±ΠΎΠ»Π΅Π΅ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠΉ Π»ΠΈΠ½ΠΈΠΈ Π‘57ΠΠ¬/61 ΡΡΠΎΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ.
2. Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ Π² ΡΡΡΡΠΊΡΡΡΠ΅ Π²ΡΠ°ΠΆΠ΄Π΅Π±Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ ΠΎΠ±Π΅ΠΈΡ Π»ΠΈΠ½ΠΈΠΉ ΠΏΡΠΎΠΈΡΡ ΠΎΠ΄ΡΡ ΡΡ ΠΎΠ΄Π½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ: Ρ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΡΡ ΡΠ°ΠΌΡΠΎΠ² Ρ ΠΎΠΏΡΡΠΎΠΌ 2-Ρ ΠΊΠΎΠ½ΡΡΠΎΠ½ΡΠ°ΡΠΈΠΈ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°ΡΡ ΠΏΡΡΠΌΡΠ΅ Π°ΡΠ°ΠΊΠΈ Π½Π° ΠΏΡΠΎΡΠΈΠ²Π½ΠΈΠΊΠ°, Π² ΡΠΎ Π²ΡΠ΅ΠΌΡ ΠΊΠ°ΠΊ ΡΠ°ΠΌΡΡ Ρ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΌ ΠΎΠΏΡΡΠΎΠΌ Π°Π³ΡΠ΅ΡΡΠΈΠΈ (20 Π΄Π½Π΅ΠΉ) ΡΠ°ΡΡΠΎ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΡΡ ΡΠΈΡΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈΠ»ΠΈ Π½Π΅ΠΏΡΡΠΌΡΠ΅ ΡΠΎΡΠΌΡ Π°Π³ΡΠ΅ΡΡΠΈΠΈ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½ΠΎΠ΅ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΠΌ Π°Π½Π°Π»ΠΈΠ·ΠΎΠΌ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΡΠΌΡΡ Π°ΡΠ°ΠΊ Π½Π° Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΡΠΉ Π³ΡΡΠΌΠΈΠ½Π³, Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ ΡΠ°Π·Π±ΡΠ°ΡΡΠ²Π°Π½ΠΈΡ ΡΡΠΆΠΎΠΉ ΠΏΠΎΠ΄ΡΡΠΈΠ»ΠΊΠΈ Π² ΡΡΡΡΠΊΡΡΡΡ Π²ΡΠ°ΠΆΠ΄Π΅Π±Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ, ΠΎΡΡΠ°ΠΆΠ°Π΅Ρ ΠΎΠ±ΡΠΈΠ΅ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΡΠΎΠ±ΡΡΠ΅Π½ΠΈΠ΅ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΡΠ°ΡΠ΅Π³ΠΈΠΈ ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ²Π½ΠΈΠΊΠ°.
3. Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ ΡΠΎΡΠΌΠΈΡΡΠ΅ΡΡΡ ΡΡΡΠΎΠΉΡΠΈΠ²Π°Ρ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½Π°Ρ ΠΌΠΎΡΠΈΠ²Π°ΡΠΈΡ, Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΠ΅ΠΌΠ°Ρ ΡΠ°ΠΌΡΠ°ΠΌΠΈ Π΄ΠΎ Π°Π³ΠΎΠ½ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ. Π£ ΡΠ°ΠΌΡΠΎΠ² Π»ΠΈΠ½ΠΈΠΈ Π‘ΠΠ/Π¬Π°Ρ ΡΡΠΎΠ²Π΅Π½Ρ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠΉ ΠΌΠΎΡΠΈΠ²Π°ΡΠΈΠΈ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅ΡΡΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ, Π° Ρ ΡΠ°ΠΌΡΠΎΠ² Π»ΠΈΠ½ΠΈΠΈ Π‘57ΠΠ¬/61 ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ.
4. ΠΠΎΠ΄ Π²Π»ΠΈΡΠ½ΠΈΠ΅ΠΌ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΎΠ±Π΅ΠΈΡ Π»ΠΈΠ½ΠΈΠΉ ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΡΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½Π°Ρ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΡ. ΠΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈ Π΅Π΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΡ (ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ) Π·Π°Π²ΠΈΡΡΡ ΠΎΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΎΠΏΡΡΠ° Π°Π³ΡΠ΅ΡΡΠΈΠΈ ΠΈ Π³Π΅Π½ΠΎΡΠΈΠΏΠ°. Π£ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ Π»ΠΈΠ½ΠΈΠΈ Π‘ΠΠ/Π¬Π°Ρ ΡΡΠΎΠ²Π΅Π½Ρ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ Π±ΡΠ» Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΠΏΠΎΠ²ΡΡΠ΅Π½ Π½Π° 10 Π΄Π΅Π½Ρ, Π° Ρ ΠΌΡΡΠ΅ΠΉ Π»ΠΈΠ½ΠΈΠΈ Π‘57ΠΠ¬/61 Π½Π° 20 Π΄Π΅Π½Ρ Π°Π³ΠΎΠ½ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΉ.
ΠΠΎΠ²ΡΠΎΡΠ½ΡΠΉ ΠΎΠΏΡΡ Π°Π³ΡΠ΅ΡΡΠΈΠΈ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΡΠ΅Ρ ΡΡΡΠ΅ΠΊΡΡ Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΠΊΠΎΠ². Π£ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ Ρ ΠΊΡΠ°ΡΠΊΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌ ΠΎΠΏΡΡΠΎΠΌ (2 Π΄Π½Ρ) Π°Π³ΡΠ΅ΡΡΠΈΠΈ Π΄ΠΈΠ°Π·Π΅ΠΏΠ°ΠΌ ΠΈ Π±ΡΡΠΏΠΈΡΠΎΠ½ ΠΎΠΊΠ°Π·ΡΠ²Π°Π»ΠΈ Π°Π½ΠΊΡΠΈΠΎΠ³Π΅Π½Π½ΡΠΉ ΡΡΡΠ΅ΠΊΡ ΠΈ ΡΠ½ΠΈΠΆΠ°Π»ΠΈ ΡΡΠΎΠ²Π΅Π½Ρ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΠ΅ΠΌΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠΈ. Π£ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ Ρ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΌ ΠΎΠΏΡΡΠΎΠΌ Π°Π³ΡΠ΅ΡΡΠΈΠΈ (20 Π΄Π½Π΅ΠΉ) Π΄ΠΈΠ°Π·Π΅ΠΏΠ°ΠΌ ΠΎΠΊΠ°Π·ΡΠ²Π°Π» Π°Π½ΠΊΡΠΈΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ ΠΈ ΡΠ½ΠΈΠΆΠ°Π» Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΡ, Π° Π±ΡΡΠΏΠΈΡΠΎΠ½ Π½Π΅ ΠΎΠΊΠ°Π·ΡΠ²Π°Π» Π½ΠΈΠΊΠ°ΠΊΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ.
ΠΠΎΠ΄ Π²Π»ΠΈΡΠ½ΠΈΠ΅ΠΌ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° ΠΏΠΎΠ±Π΅Π΄ Π² Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΡΡ Π°Π³ΠΎΠ½ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡΡ Ρ ΡΠ°ΠΌΡΠΎΠ² ΠΌΡΡΠ΅ΠΉ ΡΠΎΡΠΌΠΈΡΡΠ΅ΡΡΡ ΠΎΠ±ΡΡΠ΅Π½Π½Π°Ρ Π°Π³ΡΠ΅ΡΡΠΈΡ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠ°ΡΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌΠΈ ΠΌΠ½ΠΎΠ³ΠΈΡ ΡΠΎΡΠΌ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ. ΠΡΠΈ ΡΡΠΎΠΌ Π½Π° ΠΎΡΠΎΠ±Π΅ΠΉ Ρ ΡΠ°Π·Π½ΡΠΌΠΈ ΠΏΡΠΈΡ ΠΎΡΠΌΠΎΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌΠΈ Ρ Π°ΡΠ°ΠΊΡΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ ΠΎΠΏΡΡ Π°Π³ΡΠ΅ΡΡΠΈΠΈ ΠΌΠΎΠΆΠ΅Ρ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ ΡΠ°Π·Π½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅.
ΠΠ»Π°Π³ΠΎΠ΄Π°ΡΠ½ΠΎΡΡΠΈ.
Π Π°Π±ΠΎΡΠ° Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° Π² Π‘Π΅ΠΊΡΠΎΡΠ΅ Π½Π΅ΠΉΡΠΎΠ³Π΅Π½Π΅ΡΠΈΠΊΠΈ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΠ¦ΠΈΠ Π‘Π Π ΠΠ. ΠΠ²ΡΠΎΡ ΠΏΡΠΈΠ½ΠΎΡΠΈΡ Π³Π»ΡΠ±ΠΎΠΊΡΡ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ½ΠΎΡΡΡ Π½Π°ΡΡΠ½ΠΎΠΌΡ ΡΡΠΊΠΎΠ²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ Π΄ΠΎΠΊΡΠΎΡΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π½Π°ΡΠΊ ΠΡΠ΄ΡΡΠ²ΡΠ΅Π²ΠΎΠΉ ΠΠ°ΡΠ°Π»ΠΈΠΈ ΠΠΈΠΊΠΎΠ»Π°Π΅Π²Π½Π΅, Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΡΠ΅ΠΌ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠ°ΠΌ Π‘Π΅ΠΊΡΠΎΡΠ° Π·Π° Π²ΡΠ΅ΡΡΠΎΡΠΎΠ½Π½ΡΡ ΠΏΠΎΠΌΠΎΡΡ ΠΏΡΠΈ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠΈ ΡΠ°Π±ΠΎΡ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ².
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
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- ΠΡΠ°ΡΠ΅Π½ΠΈΠ΅ ΡΠ½Π΅Π»ΠΎ R Π — ~ — — — — — -- — -- — — — — — —
- ΠΡΠ°ΠΆΠ΄Π΅Π±Π½ΠΎΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½Π½Π΅ ΠΎΠ±ΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ R Π -0.628 0.07 0.735 0.02 0.697 0.04 0,564 0,11 0.259 0.50 -0.263 0.49 -0.325 0.39 -0.263 0.49 0.904 0.001 0.907 0.001 0.368 0.33 -0.748 0.02 0 030 0.94 -0.912 0.001 0,646 0.06 —
- ΠΡΠ°ΠΊΠΈ Π»Π°ΡΠ΅Π½ΡΠ½ΠΎΠ΅ Π²ΡΠ΅ΠΌΡ ΠΉ Π 1 — — — — — — — -- — — — —ΠΎΠ±ΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π Π -0.822 0.01 1 — — — — — — — — — —ΡΠΈΡΠ»ΠΎ Π Π -0.853 0.003 0.965 0.001 1 — — — - — — - — - — —ΡΡΠ΅Π΄Π½Π΅Π΅ Π½ΡΠ΅ΠΌΠΈ Π Ρ -0.858 0.003 0.960 0.001 0.935 0.001 1 — — — — -- — — — — — —
- Π£Π³ΡΠΎΠ·Ρ ΡΠΈΡΠ»ΠΎ ΠΊ Ρ -0.502 0 17 0600 0.09 0.754 0.02 0.475 0.20 0,593 0.09 -0.627 0.07 -0.641 0 06 -0.627 0 07 0.707 0.03 0.710 0.03 0.707 0.03 0 114 0.77 0.445 0.23 -0 069 0.86 1 —
- ΠΡΠ½ΡΠ΅Π½Π½Ρ ΡΠΈΡΠ»ΠΎ ΠΊ Ρ 0 151 0.70 -0.263 0.49 -0,368 0.33 -0.195 061 -0.579 0 10 0.544 0 13 0.621 0.07 0,217 0.57 -0,125 0.75 -0,157 0.69 0.009 0.98 -0.659 0.05 -0.713 0.03 -0.470 0.20 -0.549 0 13 1
- ΠΡΠ°ΠΆΠ΄Π΅Π±Π½ΠΎΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΎΠ±ΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Ρ 0.317 0.41 -0.310 0.42 -0.248 0.52 -0.363 0.31 -0.267 0.49 0.627 0.07 0.095 0.81 0.492 0.18 -0.050 0 90 -0.008 0 98 0 383 0.31 -0.267 0.49 -0.385 0.31 -0,318 0.40 0.114 077 0.134 0.73
- Π£Π³ΡΠΎΠ·Ρ ΡΠΈΡΠ»ΠΎ Π Π 0.127 0.68 -0.389 0.19 -0 391 0,19 -0.337 0,26 -0.245 0.42 0.321 0.29 0.321 0.29 0.320 0.29 -0.106 0.73 -0.229 0.45 0.349 0.24 0.132 0.67 0.100 0.74 0.132 0.67. -
- ΠΡΠ°ΡΠ΅Π½ΠΈΠ΅ ΡΠΈΡΠ»ΠΎ Π Π -0.359 0.23 0.166 0.59 0.242 0,43 0,201 0.51 0.277 0.36 -0.278 0.36 -0.278 0.36 -0.277 0.36 0.035 0.91 0.207 0.50 -0,149 0.63 -0 092 0.76 -0.118 0.70 0.022 0.94 -0.181 0,55 1
- ΠΡΠ°ΠΆΠ΄Π΅Π±Π½ΠΎΠ΅ ΠΏΠΎΠ²Π΅Π»Π΅Π½ΠΈΠ΅ ΠΎΠ±ΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ R Π -0.612 0.03 0.824 0.00 0.80Π 0.00 0.684 0.01 0.396 0.18 -0.519 0.07 -0.471 0.10 -0.524 0.07 0.367 0.22 -0.032 0.92 0 432 0 14 0.040 0.90 0.004 0.99 0.181 0,55 -0.236 0.44 0.061 0.84
- ΠΡΠ°ΠΊΠΈ Π»Π°ΡΠ΅Π½ΡΠ½ΠΎΠ΅ Π²ΡΠ΅ΠΌΡ Π Π 1 — -- — — — — — — — — -- — — —ΠΎΠ± ΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π Ρ -0.755 0.00 I — — — — — — — — — — — — —ΡΠΈΡΠ»ΠΎ R Π -0.848 0.00 0.954 0.00 I — — — — — — — — — — — —ΡΡΠ΅Π΄Π½Π΅Π΅ Π²ΡΠ΅ΠΌΡ R Π -0.306 0.31 0.701 0.01 0.539 0.06 I — - - — — — — — — —
- ΠΡΡΠΎΠ³ΡΡΠΌΠΈΠ½Π³ ΠΎΠ¬ΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ R Π -0.042 0.89 0.319 0.29 0 179 0.56 0.358 0.23 -0.312 0.30 0.326 0.28 0,330 0.27 0.305 0.31 -0.086 0.78 0.034 0.91 -0.139 0.65 ! — — — —
- Π£Π³ΡΠΎΠ·Ρ Π§ΠΠ‘ΠΠ R Π — — — — — — — — — -- — — — — β’β’
- ΠΡΠ°ΡΠ΅Π½ΠΈΠ΅ Π§ΠΠ‘ΠΠ R Π 0,503 0.08 -0.325 0.28 -0 468 0.11 -0.040 0,90 0.091 0.77 -0.105 0.73 -0,151 0.62 0.000 1.00 0.240 0.43 -0,212 0.49 0.457 0.12 -0.276 0.36 -0.371 0.21 -0.041 0.90 -- 1